Zobrazeno 1 - 10
of 91
pro vyhledávání: '"Jean‐François Hernandez"'
Autor:
Elodie Mauchauffée, Jérémy Leroy, Jihanne Chamcham, Abdelaziz Ejjoummany, Manon Maurel, Lionel Nauton, Booma Ramassamy, Karima Mezghenna, Jean-Luc Boucher, Anne-Dominique Lajoix, Jean-François Hernandez
Publikováno v:
Molecules, Vol 28, Iss 13, p 5085 (2023)
We previously reported dipeptidomimetic compounds as inhibitors of neuronal and/or inducible NO synthases (n/iNOS) with significant selectivity against endothelial NOS (eNOS). They were composed of an S-ethylisothiocitrullin-like moiety linked to an
Externí odkaz:
https://doaj.org/article/a86dff86d61f4940b8c1769a3e316624
Autor:
Laurent Gavara, Federica Verdirosa, Alice Legru, Paola Sandra Mercuri, Lionel Nauton, Laurent Sevaille, Georges Feller, Dorothée Berthomieu, Filomena Sannio, Francesca Marcoccia, Silvia Tanfoni, Filomena De Luca, Nohad Gresh, Moreno Galleni, Jean-Denis Docquier, Jean-François Hernandez
Publikováno v:
Biomolecules, Vol 10, Iss 8, p 1094 (2020)
To fight the increasingly worrying bacterial resistance to antibiotics, the discovery and development of new therapeutics is urgently needed. Here, we report on a new series of 1,2,4-triazole-3-thione compounds as inhibitors of metallo-β-lactamases
Externí odkaz:
https://doaj.org/article/0aebee0858594dab86b9fe9f6ecfb2af
Autor:
Htut Htut Htoo, Suveerawan Limsuvan, Onusa Thamsermsang, Jean-François Hernandez, Frédéric Checler, Piyarat Govitrapong, Narawut Pakaprot, Pravit Akarasereenont, Bruno Vincent
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0170360 (2017)
Alzheimer's disease is characterized by the deposition of insoluble amyloid-β peptides produced from the β-amyloid precursor protein (βAPP). Because α-secretase cleavage by ADAM10 and ADAM17 takes place in the middle of Aβ, its activation is con
Externí odkaz:
https://doaj.org/article/2866a16425174481989fee9205340451
Autor:
Ndeye Mathy Kebe, Krishnananda Samanta, Priyanka Singh, Joséphine Lai-Kee-Him, Viviana Apicella, Nadine Payrot, Noémie Lauraire, Baptiste Legrand, Vincent Lisowski, Diane-Ethna Mbang-Benet, Michel Pages, Patrick Bastien, Andrey V. Kajava, Patrick Bron, Jean-François Hernandez, Olivier Coux
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 5, p 1021 (2019)
HslVU is an ATP-dependent proteolytic complex present in certain bacteria and in the mitochondrion of some primordial eukaryotes, including deadly parasites such as Leishmania. It is formed by the dodecameric protease HslV and the hexameric ATPase Hs
Externí odkaz:
https://doaj.org/article/e99f6b0b89734195bb6d28a240030dcd
Publikováno v:
ElectrophoresisREFERENCES.
The use of fluorescently tagged amyloid peptides, implicated in Alzheimer's disease, to study their aggregation at low concentrations is a common method; however, the fluorescent tag should not introduce a bias in the aggregation process. In this wor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05cb624541adeb071dbefc9589a577c2
https://pubmed.ncbi.nlm.nih.gov/36308033
https://pubmed.ncbi.nlm.nih.gov/36308033
Autor:
Jean-François Hernandez, Joseph Chamieh, Luca Cipelletti, Mihai Deleanu, Jean-Philippe Biron, Myriam Taverna, Hervé Cottet, Emilie Rossi
Publikováno v:
Analytical Chemistry
Analytical Chemistry, American Chemical Society, 2021, 93 (16), pp.6523-6533. ⟨10.1021/acs.analchem.1c00527⟩
Analytical Chemistry, American Chemical Society, 2021, 93 (16), pp.6523-6533. ⟨10.1021/acs.analchem.1c00527⟩
International audience; Aggregation mechanisms of amyloid β peptides depend on multiple intrinsic and extrinsic physicochemical factors (e.g., peptide chain length, truncation, peptide concentration, pH, ionic strength, temperature, metal concentrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c16dc0287691b1d8ee9323a5d2a5e08d
https://doi.org/10.1021/acs.analchem.1c00527
https://doi.org/10.1021/acs.analchem.1c00527
Autor:
Alice Legru, Federica Verdirosa, Yen Vo-Hoang, Giusy Tassone, Filippo Vascon, Caitlyn A. Thomas, Filomena Sannio, Giuseppina Corsica, Manuela Benvenuti, Georges Feller, Rémi Coulon, Francesca Marcoccia, Savannah Rowane Devente, Ezeddine Bouajila, Catherine Piveteau, Florence Leroux, Rebecca Deprez-Poulain, Benoît Deprez, Patricia Licznar-Fajardo, Michael W. Crowder, Laura Cendron, Cecilia Pozzi, Stefano Mangani, Jean-Denis Docquier, Jean-François Hernandez, Laurent Gavara
Publikováno v:
Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, 2022, 65 (24), pp.16392-16419. ⟨10.1021/acs.jmedchem.2c01257⟩
Journal of Medicinal Chemistry, 2022, 65 (24), pp.16392-16419. ⟨10.1021/acs.jmedchem.2c01257⟩
International audience; Metallo-β-lactamases (MBLs) contribute to the resistance of Gram-negative bacteria to carbapenems, last-resort antibiotics at hospital, and MBL inhibitors are urgently needed to preserve these important antibacterial drugs. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a12a2619992adab250d34ee8e40f7d5
https://hdl.handle.net/11577/3465209
https://hdl.handle.net/11577/3465209
Autor:
Laurent, Gavara, Federica, Verdirosa, Laurent, Sevaille, Alice, Legru, Giuseppina, Corsica, Lionel, Nauton, Paola, Sandra Mercuri, Filomena, Sannio, Filomena, De Luca, Margot, Hadjadj, Giulia, Cerboni, Yen, Vo Hoang, Patricia, Licznar-Fajardo, Moreno, Galleni, Jean-Denis, Docquier, Jean-François, Hernandez
Publikováno v:
Bioorganic and Medicinal Chemistry
Bioorganic and Medicinal Chemistry, 2022, 72, pp.116964. ⟨10.1016/j.bmc.2022.116964⟩
Bioorganic and Medicinal Chemistry, 2022, 72, pp.116964. ⟨10.1016/j.bmc.2022.116964⟩
International audience; Metallo-β-lactamases (MBLs) represent an increasingly serious threat to public health because of their increased prevalence worldwide in relevant opportunistic Gram-negative pathogens. MBLs efficiently inactivate widely used
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2ccc5a7fb5d5ee9e7946fc5eee59ccb
https://hal.science/hal-03767295/file/GavaraL_Manuscript.pdf
https://hal.science/hal-03767295/file/GavaraL_Manuscript.pdf
Autor:
Federica Verdirosa, Laurent Gavara, Laurent Sevaille, Giusy Tassone, Giuseppina Corsica, Alice Legru, Georges Feller, Giulia Chelini, Paola Sandra Mercuri, Silvia Tanfoni, Filomena Sannio, Manuela Benvenuti, Giulia Cerboni, Filomena De Luca, Ezeddine Bouajila, Yen Vo Hoang, Patricia Licznar‐Fajardo, Moreno Galleni, Cecilia Pozzi, Stefano Mangani, Jean‐Denis Docquier, Jean‐François Hernandez
Publikováno v:
ChemMedChem
ChemMedChem, 2022, 17 (7), pp.e202100699. ⟨10.1002/cmdc.202100699⟩
ChemMedChem, 2022, 17 (7), pp.e202100699. ⟨10.1002/cmdc.202100699⟩
International audience; Metallo-β-lactamases (MBLs) are increasingly involved as a major mechanism of resistance to carbapenems in relevant opportunistic Gram-negative pathogens. Unfortunately, clinically efficient MBL inhibitors still represent an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::011fe1a4157816725b1cc80ca54772d4
https://pubmed.ncbi.nlm.nih.gov/35050549
https://pubmed.ncbi.nlm.nih.gov/35050549
Autor:
Alice Legru, Filomena Sannio, Federica Verdirosa, Giulia Chelini, Paola Sandra Mercuri, Silvia Tanfoni, Filomena De Luca, Giuseppina Corsica, Rémi Coulon, Jean-François Hernandez, Georges Feller, Laurent Sevaille, Moreno Galleni, Lionel Nauton, Laurent Gavara, Jean Denis Docquier, Giulia Cerboni
Publikováno v:
Bioorganic Chemistry
Bioorganic Chemistry, Elsevier, 2021, 113, pp.105024. ⟨10.1016/j.bioorg.2021.105024⟩
Bioorganic Chemistry, Elsevier, 2021, 113, pp.105024. ⟨10.1016/j.bioorg.2021.105024⟩
In Gram-negative bacteria, the major mechanism of resistance to β-lactam antibiotics is the production of one or several β-lactamases (BLs), including the highly worrying carbapenemases. Whereas inhibitors of these enzymes were recently marketed, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdab0611f2557328eea500d9bc351753
https://hal.archives-ouvertes.fr/hal-03358457
https://hal.archives-ouvertes.fr/hal-03358457