Zobrazeno 1 - 10
of 146
pro vyhledávání: '"Jean‐François Goossens"'
Publikováno v:
MethodsX, Vol 12, Iss , Pp 102771- (2024)
Emerging pollutants derived from human and animal sources, are present in soils and pose significant environmental and health impacts, even at low concentrations. Their detection in soil is analytically complex due to soil interference and the rapid
Externí odkaz:
https://doaj.org/article/8ff96688c4594344a8ad4d5190903dc4
Autor:
Céline Schulz, Quentin Lemaire, Alexandre Berthier, Amandine Descat, Mostafa Kouach, Anne‐Sophie Vercoutter‐Edouart, Ikram El Yazidi‐Belkoura, Stéphan Hardivillé, Jean‐François Goossens, Philippe Lefebvre, Tony Lefebvre
Publikováno v:
Natural Sciences, Vol 3, Iss 2, Pp n/a-n/a (2023)
Abstract O‐GlcNAcylation is a post‐translational modification belonging to the large group of glycosylations. It consists of the modification of cytoplasmic, nuclear, and mitochondrial proteins with a single N‐acetylglucosamine residue by O‐G
Externí odkaz:
https://doaj.org/article/ef8c5d8469834b5285cbfe60fe031f8c
Autor:
Romain Regnault, Frédérique Klupsch, Hassiba El-Bouazzati, Romain Magnez, Raphaël Le Biannic, Natascha Leleu-Chavain, Hania Ahouari, Hervé Vezin, Régis Millet, Jean-François Goossens, Xavier Thuru, Christian Bailly
Publikováno v:
Molecules, Vol 28, Iss 8, p 3491 (2023)
Orally-active anticancer small molecules targeting the PD-1/PD-L1 immune checkpoint are actively searched. Phenyl-pyrazolone derivatives with a high affinity for PD-L1 have been designed and characterized. In addition, the phenyl-pyrazolone unit acts
Externí odkaz:
https://doaj.org/article/e4b8fd713f14437dbeba68169e10a2a0
Autor:
Natascha Leleu-Chavain, Romain Regnault, Hania Ahouari, Raphaël Le Biannic, Mostafa Kouach, Frédérique Klupsch, Romain Magnez, Hervé Vezin, Xavier Thuru, Christian Bailly, Jean-François Goossens, Régis Millet
Publikováno v:
Molecules, Vol 27, Iss 10, p 3316 (2022)
Small molecules targeting the PD-1/PD-L1 checkpoint are actively searched to complement the anticancer arsenal. Different molecular scaffolds have been reported, including phenyl-pyrazolone derivatives which potently inhibit binding of PD-L1 to PD-1.
Externí odkaz:
https://doaj.org/article/2213cf7b7fe44b0d864af0447bcfb049
Autor:
Heloise Henry, Jean-François Goossens, Mostafa Kouach, Damien Lannoy, David Seguy, Thierry Dine, Pascal Odou, Catherine Foulon
Publikováno v:
Pharmaceutics, Vol 14, Iss 5, p 1081 (2022)
Parenteral-nutrition (PN)-induced hyperglycemia increases morbidity and mortality and must be treated with insulin. Unfortunately, the addition of insulin to a ternary PN admixture leads to a rapid decrease in insulin content. Our study’s objective
Externí odkaz:
https://doaj.org/article/082912b00ff142dfb3726089687318d2
Autor:
Julie Fahier, Branko Vukosavljevic, Laure De Kinder, Hugues Florin, Jean-François Goossens, Maike Windbergs, Florence Siepmann, Juergen Siepmann, Susanne Muschert
Publikováno v:
Pharmaceutics, Vol 13, Iss 10, p 1723 (2021)
The aim of this study was to gain deeper insight into the mass transport mechanisms controlling drug release from polymer-coated pellets using non-invasive analytical tools. Pellet starter cores loaded with verapamil HCl (10% loading, 45% lactose, 45
Externí odkaz:
https://doaj.org/article/0a9fdf2949974371a88bf31daa46613f
Autor:
Aurélie Thelliez, Grégory Hénard, Bruno Delorme, Sonia Chatellier, Cécile Danel, Laurent Ducoroy, Annabelle Dupont, Delphine Garrigue, Stéphanie Genay, Jean-François Goossens, Laurence Goossens, Coralie Havet, Jean-Daniel Hecq, Caroline Maeght, Isabelle Mendel, Tomé Najdovski, Pascal Odou, Guillaume Saint-Lorant, Alexandre Ung, Marie Lecoeur, Bertrand Décaudin
Publikováno v:
Biomolecules, Vol 11, Iss 8, p 1081 (2021)
Potentially toxic plasticizers are commonly added to polyvinyl chloride medical devices for transfusion in order to improve their flexibility and workability. As the plasticizers are not chemically bonded to the PVC, they can be released into labile
Externí odkaz:
https://doaj.org/article/0ec4a3bd93204639af369c52852ff81a
Autor:
André-Guilhem Calas, Anne-Sophie Hanak, Nina Jaffré, Aurélie Nervo, José Dias, Catherine Rousseau, Charlotte Courageux, Xavier Brazzolotto, Pascal Villa, Adeline Obrecht, Jean-François Goossens, Christophe Landry, Johan Hachani, Fabien Gosselet, Marie-Pierre Dehouck, Jagadeesh Yerri, Maria Kliachyna, Rachid Baati, Florian Nachon
Publikováno v:
Biomolecules, Vol 10, Iss 6, p 858 (2020)
(1) Background: Human exposure to organophosphorus compounds employed as pesticides or as chemical warfare agents induces deleterious effects due to cholinesterase inhibition. One therapeutic approach is the reactivation of inhibited acetylcholineste
Externí odkaz:
https://doaj.org/article/c8ad1bdb8ca0419e90bec0584f145514
Autor:
Rémi Przybylski, Laurent Bazinet, Loubna Firdaous, Mostafa Kouach, Jean-François Goossens, Pascal Dhulster, Naïma Nedjar-Arroume
Publikováno v:
Membranes, Vol 10, Iss 5, p 90 (2020)
The fractionation of bioactive peptides from hydrolysate is a main challenge to produce efficient alternative for synthetic additives. In this work, electrodialysis with ultrafiltration membrane (EDUF) was proposed to increase the purity of one antim
Externí odkaz:
https://doaj.org/article/392a520088df4e4ba1b908b283cdf6d2
Autor:
Dorothée Domenger, Benoit Cudennec, Mostafa Kouach, Véronique Touche, Christophe Landry, Jean Lesage, Fabien Gosselet, Sophie Lestavel, Jean-François Goossens, Pascal Dhulster, Rozenn Ravallec
Publikováno v:
Frontiers in Endocrinology, Vol 9 (2018)
A qualitative study is presented, where the main question was whether food-derived hemorphins, i.e., originating from digested alimentary hemoglobin, could pass the intestinal barrier and/or the blood–brain barrier (BBB). Once absorbed, hemorphins
Externí odkaz:
https://doaj.org/article/67c39af328324436a301edc3d43ba8de