Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Jean‐Frédéric Dubern"'
Autor:
Jean-Frédéric Dubern, Manuel Romero, Anne Mai-Prochnow, Marco Messina, Eleftheria Trampari, Hardeep Naghra-van Gijzel, Kok-Gan Chan, Alessandro M. Carabelli, Nicolas Barraud, James Lazenby, Ye Chen, Shaun Robertson, Jacob G. Malone, Paul Williams, Stephan Heeb, Miguel Cámara
Publikováno v:
npj Biofilms and Microbiomes, Vol 8, Iss 1, Pp 1-12 (2022)
Abstract Pseudomonas aeruginosa uses multiple protein regulators that work in tandem to control the production of a wide range of virulence factors and facilitate rapid adaptation to diverse environmental conditions. In this opportunistic pathogen, T
Externí odkaz:
https://doaj.org/article/4aa08aca28374cf58e283dd4b2ed23e6
Autor:
Yinfeng He, Meisam Abdi, Gustavo F. Trindade, Belén Begines, Jean‐Frédéric Dubern, Elisabetta Prina, Andrew L. Hook, Gabriel Y. H. Choong, Javier Ledesma, Christopher J. Tuck, Felicity R. A. J. Rose, Richard J. M. Hague, Clive J. Roberts, Davide S. A. De Focatiis, Ian A. Ashcroft, Paul Williams, Derek J. Irvine, Morgan R. Alexander, Ricky D. Wildman
Publikováno v:
Advanced Science, Vol 8, Iss 15, Pp n/a-n/a (2021)
Abstract As the understanding of disease grows, so does the opportunity for personalization of therapies targeted to the needs of the individual. To bring about a step change in the personalization of medical devices it is shown that multi‐material
Externí odkaz:
https://doaj.org/article/cefd52a30eb143278eebb152ea85494f
Autor:
Samuel Fenn, Jean-Frédéric Dubern, Cristina Cigana, Maura De Simone, James Lazenby, Mario Juhas, Stephan Schwager, Irene Bianconi, Gerd Döring, Jonas Elmsley, Leo Eberl, Paul Williams, Alessandra Bragonzi, Miguel Cámara
Publikováno v:
mBio, Vol 12, Iss 2 (2021)
The emergence of widespread antimicrobial resistance has led to the need for development of novel therapeutic interventions. Antivirulence strategies are an attractive alternative to classic antimicrobial therapy; however, they require identification
Externí odkaz:
https://doaj.org/article/afb4e30e21634b5e896ebe24694c0eaa
Autor:
Andrew L. Hook, James L. Flewellen, Jean-Frédéric Dubern, Alessandro M. Carabelli, Irwin M. Zaid, Richard M. Berry, Ricky D. Wildman, Noah Russell, Paul Williams, Morgan R. Alexander
Publikováno v:
mSystems, Vol 4, Iss 5 (2019)
ABSTRACT Bacteria sense chemicals, surfaces, and other cells and move toward some and away from others. Studying how single bacterial cells in a population move requires sophisticated tracking and imaging techniques. We have established quantitative
Externí odkaz:
https://doaj.org/article/fe0ad18bb1004ea5ada2c4ae39a439b1
Autor:
Yi-Chia Liu, Farah Hussain, Ola Negm, Ana Carolina Paiva, Nigel Halliday, Jean-Frédéric Dubern, Sonali Singh, Sirina Muntaka, Lee Wheldon, Jeni Luckett, Paddy Tighe, Cynthia Bosquillon, Paul Williams, Miguel Cámara, Luisa Martínez-Pomares
Publikováno v:
Frontiers in Microbiology, Vol 10 (2019)
Externí odkaz:
https://doaj.org/article/5bfea767cbb3428f9c93426858299784
Autor:
Yi-Chia Liu, Farah Hussain, Ola Negm, Ana Carolina Paiva, Nigel Halliday, Jean-Frédéric Dubern, Sonali Singh, Sirina Muntaka, Lee Wheldon, Jeni Luckett, Paddy Tighe, Cynthia Bosquillon, Paul Williams, Miguel Cámara, Luisa Martínez-Pomares
Publikováno v:
Frontiers in Microbiology, Vol 9 (2018)
Pseudomonas aeruginosa causes infections in patients with compromised epithelial barrier function. Multiple virulence factors produced by P. aeruginosa are controlled by quorum sensing (QS) via 2-alkyl-4(1H)-quinolone (AQ) signal molecules. Here, we
Externí odkaz:
https://doaj.org/article/7768fadfc0b6451e976ef01382763b12
Autor:
Giordano Rampioni, Marilena Falcone, Stephan Heeb, Emanuela Frangipani, Matthew P Fletcher, Jean-Frédéric Dubern, Paolo Visca, Livia Leoni, Miguel Cámara, Paul Williams
Publikováno v:
PLoS Pathogens, Vol 12, Iss 11, p e1006029 (2016)
The pqs quorum sensing (QS) system is crucial for Pseudomonas aeruginosa virulence both in vitro and in animal models of infection and is considered an ideal target for the development of anti-virulence agents. However, the precise role played by eac
Externí odkaz:
https://doaj.org/article/932d4010819a4f31922b1c8e88c0ccc4
Autor:
Fadi Soukarieh, Eduard Vico Oton, Jean-Frédéric Dubern, Janice Gomes, Nigel Halliday, Maria de Pilar Crespo, Jonathan Ramírez-Prada, Braulio Insuasty, Rodrigo Abonia, Jairo Quiroga, Stephan Heeb, Paul Williams, Michael J. Stocks, Miguel Cámara
Publikováno v:
Molecules, Vol 23, Iss 2, p 257 (2018)
Pseudomonas aeruginosa is a major opportunistic pathogen in cystic fibrosis, wound and nosocomial infections, posing a serious burden to public health, due to its antibiotic resistance. The P. aeruginosa Pseudomonas Quinolone System (pqs) quorum sens
Externí odkaz:
https://doaj.org/article/856d553f11b54b4c94febaa502d9c89a
Autor:
Jun Li, Yang Yang, Jean-Frédéric Dubern, Hui Li, Nigel Halliday, Leonid Chernin, Kexiang Gao, Miguel Cámara, Xiaoguang Liu
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0137553 (2015)
The GacS/GacA two-component system plays a central role in the regulation of a broad range of biological functions in many bacteria. In the biocontrol organism Pseudomonas chlororaphis, the Gac system has been shown to positively control quorum sensi
Externí odkaz:
https://doaj.org/article/701c3f59bf6a4db1923bc3fa44d9979e
Autor:
Valentina Cuzzucoli Crucitti, Aleksandar Ilchev, Jonathan C. Moore, Harriet R. Fowler, Jean-Frédéric Dubern, Olutoba Sanni, Xuan Xue, Bethany K. Husband, Adam A. Dundas, Sean Smith, Joni L. Wildman, Vincenzo Taresco, Paul Williams, Morgan R. Alexander, Steven M. Howdle, Ricky D. Wildman, Robert A. Stockman, Derek J. Irvine
Publikováno v:
Biomacromolecules. 24:576-591
Presented in this work is the use of a molecular descriptor, termed the α parameter, to aid in the design of a series of novel, terpene-based, and sustainable polymers that were resistant to biofilm formation by the model bacterial pathogen