Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Jean‐David Morel"'
Autor:
Arwen W. Gao, Gaby El Alam, Yunyun Zhu, Weisha Li, Jonathan Sulc, Xiaoxu Li, Elena Katsyuba, Terytty Y. Li, Katherine A. Overmyer, Amelia Lalou, Laurent Mouchiroud, Maroun Bou Sleiman, Matteo Cornaglia, Jean-David Morel, Riekelt H. Houtkooper, Joshua J. Coon, Johan Auwerx
Publikováno v:
Cell Reports, Vol 43, Iss 10, Pp 114836- (2024)
Summary: Lifespan is influenced by complex interactions between genetic and environmental factors. Studying those factors in model organisms of a single genetic background limits their translational value for humans. Here, we mapped lifespan determin
Externí odkaz:
https://doaj.org/article/f30f2e821b914d2aa267921774dc8718
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 12, p e1011757 (2023)
The most common reported epidemic time series in epidemiological surveillance are the daily or weekly incidence of new cases, the hospital admission count, the ICU admission count, and the death toll, which played such a prominent role in the struggl
Externí odkaz:
https://doaj.org/article/276da39455a9455586be813560c8ff72
Autor:
Xiaoxu Li, Jean-David Morel, Giorgia Benegiamo, Johanne Poisson, Alexis Bachmann, Alexis Rapin, Jonathan Sulc, Evan Williams, Alessia Perino, Kristina Schoonjans, Maroun Bou Sleiman, Johan Auwerx
Publikováno v:
eLife, Vol 12 (2023)
Inflammatory gut disorders, including inflammatory bowel disease (IBD), can be impacted by dietary, environmental, and genetic factors. While the incidence of IBD is increasing worldwide, we still lack a complete understanding of the gene-by-environm
Externí odkaz:
https://doaj.org/article/8be70e9354e742299013c37a8d97b8b1
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 6, p e1010790 (2023)
The COVID-19 pandemy has created a radically new situation where most countries provide raw measurements of their daily incidence and disclose them in real time. This enables new machine learning forecast strategies where the prediction might no long
Externí odkaz:
https://doaj.org/article/9d34fe9afeee49ed9aec5e529a4aa96d
Autor:
Jean-David Morel, Lucie Sauzéat, Ludger J. E. Goeminne, Pooja Jha, Evan Williams, Riekelt H. Houtkooper, Ruedi Aebersold, Johan Auwerx, Vincent Balter
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-8 (2022)
The metallome is crucial for normal cell functioning but remains largely overlooked in mammals. Here the authors analyze the metallome and copper and zinc isotope compositions in aging mice and show networks of interactions that are organ-specific, a
Externí odkaz:
https://doaj.org/article/b4a85b68c460439faeccc786e2c1e1b3
Autor:
Jean-David Morel, Maroun Bou Sleiman, Terytty Yang Li, Giacomo von Alvensleben, Alexis M. Bachmann, Dina Hofer, Ellen Broeckx, Jing Ying Ma, Vinicius Carreira, Tao Chen, Nabil Azhar, Romer A. Gonzalez-Villalobos, Matthew Breyer, Dermot Reilly, Shannon Mullican, Johan Auwerx
Publikováno v:
JCI Insight, Vol 8, Iss 3 (2023)
Acute kidney failure and chronic kidney disease are global health issues steadily rising in incidence and prevalence. Animal models on a single genetic background have so far failed to recapitulate the clinical presentation of human nephropathies. He
Externí odkaz:
https://doaj.org/article/447e3d3507944ce3b973bd6bb820b8da
Autor:
Alexis Maximilien Bachmann, Jean-David Morel, Gaby El Alam, Sandra Rodríguez-López, Tanes Imamura de lima, Ludger J.E. Goeminne, Giorgia Benegiamo, Sylvain Loric, Marc Conti, Maroun Bou Sleiman, Johan Auwerx
Publikováno v:
iScience, Vol 25, Iss 6, Pp 104468- (2022)
Summary: The sharp increase in obesity prevalence worldwide is mainly attributable to changes in physical activity and eating behavior but the metabolic and clinical impacts of these obesogenic conditions vary between sexes and genetic backgrounds. T
Externí odkaz:
https://doaj.org/article/2c2e4f4c87774adbab3ccd8960b7f742
Autor:
Bruno Tello Rubio, Florence Bugault, Blandine Baudon, Bertrand Raynal, Sébastien Brûlé, Jean-David Morel, Sarah Saint-Auret, Nicolas Blanchard, Caroline Demangel, Laure Guenin-Macé
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Mycolactone is a diffusible lipid toxin produced by Mycobacterium ulcerans, the causative agent of Buruli ulcer disease. Altough bacterially derived mycolactone has been shown to traffic from cutaneous foci of infection to the bloodstream, the mechan
Externí odkaz:
https://doaj.org/article/686671b24ba34cd3a90a370297460600
Autor:
Laure Guenin-Macé, Jean-David Morel, Jean-Marc Doisne, Angèle Schiavo, Lysiane Boulet, Véronique Mayau, Pedro Goncalves, Sabine Duchatelet, Alain Hovnanian, Vincent Bondet, Darragh Duffy, Marie-Noëlle Ungeheuer, Maïa Delage, Aude Nassif, James P. Di Santo, Caroline Demangel
Publikováno v:
JCI Insight, Vol 5, Iss 20 (2020)
Hidradenitis suppurativa (HS) is a chronic skin disorder of unknown etiology that manifests as recurrent, painful lesions. Cutaneous dysbiosis and unresolved inflammation are hallmarks of active HS, but their origin and interplay remain unclear. Our
Externí odkaz:
https://doaj.org/article/2a3a8ce02ea0423f975062fcc00a44d4
Publikováno v:
Biology, Vol 11, Iss 4, p 540 (2022)
The sanitary crisis of the past two years has focused the public’s attention on quantitative indicators of the spread of the COVID-19 pandemic. The daily reproduction number Rt, defined by the average number of new infections caused by a single inf
Externí odkaz:
https://doaj.org/article/e9a5d76ee7fb4d0e8a20ed072a6b54d2