Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Jean‐Cosme Dodart"'
Autor:
Madeline M. Vroom, Jean-Cosme Dodart
Publikováno v:
Vaccines, Vol 12, Iss 9, p 973 (2024)
Neurodegenerative diseases (ND) give rise to significant declines in motor, autonomic, behavioral, and cognitive functions. Of these conditions, Alzheimer’s disease (AD) and Parkinson’s disease (PD) are the most prevalent, impacting over 55 milli
Externí odkaz:
https://doaj.org/article/0989ce205cde46a788e9c0fa31d377ff
Autor:
Madeline M. Vroom, Hanxin Lu, Maggie Lewis, Brett A. Thibodeaux, Jeanne K. Brooks, Matthew S. Longo, Martina M. Ramos, Jaya Sahni, Jonathan Wiggins, Justin D. Boyd, Shixia Wang, Shuang Ding, Michael Hellerstein, Valorie Ryan, Peter Powchik, Jean-Cosme Dodart
Publikováno v:
Journal of Lipid Research, Vol 65, Iss 2, Pp 100497- (2024)
Atherosclerotic cardiovascular disease (ASCVD) remains the leading cause of disease burden in the world and is highly correlated with chronic elevations of LDL-C. LDL-C-lowering drugs, such as statins or monoclonal antibodies against proprotein conve
Externí odkaz:
https://doaj.org/article/3293558416e04bdf9098883c37ef7a6e
Autor:
Hui Jing Yu, Samuel P. Dickson, Pei-Ning Wang, Ming-Jang Chiu, Chin-Chang Huang, Chiung-Chih Chang, Hope Liu, Suzanne B. Hendrix, Jean-Cosme Dodart, Ajay Verma, Chang Yi Wang, Jeffrey Cummings
Publikováno v:
EBioMedicine, Vol 94, Iss , Pp 104665- (2023)
Summary: Background: Anti-amyloid vaccines may offer a convenient, affordable, and accessible means of preventing and treating Alzheimer's disease. UB-311 is an anti–amyloid-β active immunotherapeutic vaccine shown to be well-tolerated and to have
Externí odkaz:
https://doaj.org/article/e0d10c1151da41e3866df1f7753243bb
Autor:
Shixia Wang, Farshad Guirakhoo, Sivakumar Periasamy, Valorie Ryan, Jonathan Wiggins, Chandru Subramani, Brett Thibodeaux, Jaya Sahni, Michael Hellerstein, Natalia A. Kuzmina, Alexander Bukreyev, Jean-Cosme Dodart, Alexander Rumyantsev
Publikováno v:
Vaccines, Vol 12, Iss 1, p 40 (2023)
Antibodies provide critical protective immunity against COVID-19, and the Fc-mediated effector functions and mucosal antibodies also contribute to the protection. To expand the characterization of humoral immunity stimulated by subunit protein–pept
Externí odkaz:
https://doaj.org/article/3bd90e0903d2463bbdf1e486c081e889
Autor:
Jacqui T. Nimmo, Ajay Verma, Jean-Cosme Dodart, Chang Yi Wang, Jimmy Savistchenko, Ronald Melki, Roxana O. Carare, James A. R. Nicoll
Publikováno v:
Alzheimer’s Research & Therapy, Vol 15, Iss 1, Pp 1-3 (2023)
Externí odkaz:
https://doaj.org/article/447ea994616d4ac8b55d79623083c238
Autor:
Yuanjing Liu, Jean-Cosme Dodart, Helene Tran, Shaunna Berkovitch, Maurine Braun, Michael Byrne, Ann F. Durbin, Xiao Shelley Hu, Naoki Iwamoto, Hyun Gyung Jang, Pachamuthu Kandasamy, Fangjun Liu, Kenneth Longo, Jörg Ruschel, Juili Shelke, Hailin Yang, Yuan Yin, Amy Donner, Zhong Zhong, Chandra Vargeese, Robert H. Brown
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
C9orf72 expansion mutations are the most common genetic cause of ALS and FTD, which have limited therapies. The authors generate stereopure oligonucleotides that selectively deplete expansion-containing transcripts and protect against expansion-assoc
Externí odkaz:
https://doaj.org/article/c67a2cf526554819ac5be15eaecb07de
Autor:
Jacqui T. Nimmo, Ajay Verma, Jean-Cosme Dodart, Chang Yi Wang, Jimmy Savistchenko, Ronald Melki, Roxana O. Carare, James A. R. Nicoll
Publikováno v:
Alzheimer’s Research & Therapy, Vol 12, Iss 1, Pp 1-16 (2020)
Abstract Background Alpha-synuclein (α-Syn) aggregation is the primary characteristic of synucleinopathies including Parkinson’s disease (PD), dementia with Lewy bodies (DLB) and multiple system atrophy (MSA). Immunotherapy targeting α-Syn has sh
Externí odkaz:
https://doaj.org/article/5506ca7a32bf4a21a4d9aa150641dafa
Autor:
Jacqui Taryn Nimmo, Louise Kelly, Ajay Verma, Roxana O. Carare, James A. R. Nicoll, Jean-Cosme Dodart
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
Alzheimer’s disease and Lewy body diseases are the most common causes of neurodegeneration and dementia. Amyloid-beta (Aβ) and alpha-synuclein (αSyn) are two key proteins involved in the pathogenesis of these neurodegenerative diseases. Immunothe
Externí odkaz:
https://doaj.org/article/7709774170b7468ab7a8c35fa052fef2
Autor:
Alexandra J. Mably, Wen Liu, Jessica M. Mc Donald, Jean-Cosme Dodart, Frédérique Bard, Cynthia A. Lemere, Brian O'Nuallain, Dominic M. Walsh
Publikováno v:
Neurobiology of Disease, Vol 82, Iss , Pp 372-384 (2015)
Compelling genetic evidence links the amyloid precursor protein (APP) to Alzheimer's disease (AD). A leading hypothesis proposes that a small amphipathic fragment of APP, the amyloid β-protein (Aβ), self-associates to form soluble assemblies loosel
Externí odkaz:
https://doaj.org/article/afee23fa7f1540d192cf9316420c48a9
Autor:
Jean-Cosme Dodart, Chantal Mathis, Josep Saura, Kelly R. Bales, Steven M. Paul, Arielle Ungerer
Publikováno v:
Neurobiology of Disease, Vol 7, Iss 2, Pp 71-85 (2000)
Histological analyses were performed on the brains of APPV717F transgenic (Tg)mice previously studied in a battery of behavioral tests. We describe here the regional and age-dependent deposition of amyloid in both heterozygous and homozygous Tg mice.
Externí odkaz:
https://doaj.org/article/e0c3a31146564671842d8f1bdd09d3eb