Neutrophil extracellular trap cell death requires both autophagy and superoxide generation

Autor: Riet De Rycke, Ellen Wirawan, Quinten Remijsen, Eef Parthoens, Jean Willems, Samuel Noppen, Michel Delforge, Peter Vandenabeele, Tom Vanden Berghe, Bob Asselbergh

Publikováno v: Cell Research; Vol 21

Neutrophil extracellular traps (NETs) are extracellular chromatin structures that can trap and degrade microbes. They arise from neutrophils that have activated a cell death program called NET cell death, or NETosis. Activation of NETosis has been sh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c790e693866a420c8d0ca8efab49e7f
https://doi.org/10.1038/cr.2010.150

Inhibition of spontaneous neutrophil apoptosis by parabutoporin acts independently of NADPH oxidase inhibition but by lipid raft-dependent stimulation of Akt

Autor: Eef Parthoens, Tom Vanden Berghe, Bob Asselbergh, Peter Vandenabeele, Quinten Remijsen, Jean Willems

Publikováno v: Journal of Leukocyte Biology; Vol 85

Neutrophil cell death plays a crucial role in neutrophil homeostasis and the resolution of inflammation. The superoxide-producing NADPH oxidase is involved in pathogen degradation and subsequent activation of cell death programs. Neutrophils from pat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::970e0944c145404fb2afcf52333e4969
https://doi.org/10.1189/jlb.0908525

Cyclic amp-induced differentiation increases the synthesis of extracellular superoxide dismutase in rat c6 glioma

Autor: Herman Slegers, Jean Willems, An Zwijsen, Els Van Mechelen, Stefan Nicolai

Publikováno v: Free radical biology and medicine

The effect of membrane permeable cAMP analogues on the expression of extracellular superoxide dismutase (EC-SOD) was studied in rat C6 glioma. EC-SOD is constitutively expressed but stimulation with cAMP analogues still increased the EC-SOD transcrip

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fd5595eacdf1d83d74ad0dfc6558e22
https://doi.org/10.1016/0891-5849(96)00122-0

Polar agents with differentiation inducing capacity potentiate tumor necrosis factor-mediated cytotoxicity in human myeloid cell lines

Autor: Bart Vanhaesebroeck, Marcel Joniau, Stany Depraetere, Walter Fiers, Jean Willems

Publikováno v: Journal of Leukocyte Biology. 57:141-151

Cotreatment or pretreatment of several human myeloid cell lines (KG1, HL60, U937, THP1) with the differentiation inducer DMSO was found to potentiate the antiproliferative and cytotoxic effects of TNF. In addition, TNF-resistant monocytic cell lines

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69d267b5073160bc859bcd1438977b58
https://doi.org/10.1002/jlb.57.1.141

Cupiennin 1a exhibits a remarkably broad, non-stereospecific cytolytic activity on bacteria, protozoan parasites, insects, and human cancer cells

Autor: Marcel Kaiser, Lucia Kuhn-Nentwig, Thomas Seebeck, Tarek Shalaby, Jean Willems, Wolfgang Nentwig

Publikováno v: Kuhn-Nentwig, Lucia; Willems, Jean; Seebeck, Thomas; Shalaby, Tarek; Kaiser, Marcel; Nentwig, Wolfgang (2011). Cupiennin 1a exhibits a remarkably broad, non-stereospecific cytolytic activity on bacteria, protozoan parasites, insects, and human cancer cells. Amino acids, 40(1), pp. 69-76. Wien: Springer Vienna 10.1007/s00726-009-0471-0

Cupiennin 1a, a cytolytic peptide isolated from the venom of the spider Cupiennius salei, exhibits broad membranolytic activity towards bacteria, trypanosomes, and plasmodia, as well as human blood and cancer cells. In analysing the cytolytic activit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac101fcc854badae180d18115b5a7561
https://pubmed.ncbi.nlm.nih.gov/20140690