Výsledky vyhledávání - "Jean, Wagnon"

Anxiolytic- and antidepressant-like effects of the non-peptide vasopressin V 1b receptor antagonist, SSR149415, suggest an innovative approach for the treatment of stress-related disorders

Autor: J P Maffrand, Jean Wagnon, Claudine Serradeil-Le Gal, Jacques Simiand, Guy Griebel, Bernard Scatton, Marc Pascal, Philippe Soubrie

Publikováno v: Proceedings of the National Academy of Sciences. 99:6370-6375

The limbic localization of the arginine vasopressin V 1b receptor has prompted speculation as to a potential role of this receptor in the control of emotional processes. To investigate this possibility, we have studied the behavioral effects of SSR14

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdf991ff7bbb0d9a1467f18128d4a79f
https://doi.org/10.1073/pnas.092012099

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Characterization of (2S,4R)-1-[5-Chloro-1-[(2,4-dimethoxyphenyl)sulfonyl]-3-(2-methoxy-phenyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-4-hydroxy-N,N-dimethyl-2-pyrrolidine carboxamide (SSR149415), a Selective and Orally Active Vasopressin V1bReceptor Antagonist

Autor: Rebecca M. Pruss, Claude Barberis, Jacques Simiand, Colette Lacour, D. Nisato, Gabrielle Brossard, Philippe Soubrie, Jean Wagnon, Guy Griebel, Claudine Serradeil-Le Gal, Gérard Le Fur, J P Maffrand, Marc Pascal, Bernard Scatton, Gilles Guillon

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 300:1122-1130

(2S,4R)-1-[5-Chloro-1-[(2,4-dimethoxyphenyl)sulfonyl]-3-(2-methoxy-phenyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-4-hydroxy-N,N-dimethyl-2-pyrrolidine carboxamide (SSR149415), the first selective, nonpeptide vasopressin V1b receptor antagonist yet describe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::58f67d43bd81433e1f53f82c12eebbf4
https://doi.org/10.1124/jpet.300.3.1122

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Biological characterization of rodent and human vasopressin V1b receptors using SSR-149415, a nonpeptide V1b receptor ligand

Autor: John Allen, Maria A. Ventura, Jörg Blankenstein, Jean Wagnon, Brigitte Pouzet, Claudine Serradeil-Le Gal, Danièle Raufaste, Marc Pascal, Sylvain Derick

Publikováno v: American journal of physiology. Regulatory, integrative and comparative physiology. 293(2)

[3H]SSR-149415 is the first tritiated nonpeptide vasopressin V1breceptor (V1bR) antagonist ligand. It was used for studying rodent (mouse, rat, hamster) and human V1bR from native or recombinant origin. Moreover, a close comparison between the human

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92e626a81f3863a940afd12fc6196278
https://pubmed.ncbi.nlm.nih.gov/17522130

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Biochemical and pharmacological properties of SR 49059, a new, potent, nonpeptide antagonist of rat and human vasopressin V1a receptors

Autor: G. Le Fur, P. Guiraudou, C Serradeil-Le Gal, B Christophe, J P Maffrand, D. Nisato, Colette Lacour, Jean Wagnon, G. Villanova, Corinne Garcia

SR 49059, a new potent and selective orally active, nonpeptide vasopressin (AVP) antagonist has been characterized in several in vitro and in vivo models. SR 49059 showed high affinity for V1a receptors from rat liver (Ki = 1.6 +/- 0.2) and human pla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::745eb9f9e958e6e1fdb41cb3bd1490ce
https://europepmc.org/articles/PMC293574/

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Renin inhibitors. Free-Wilson and correlation analysis of the inhibitory potency of a series of pepstatin analogues on plasma renin

Autor: Dino Nisato, Jean Wagnon, Claude Plouzane, Vladimir Pliška, Georges Callet, Bernard Tonnerre, Jean Louis Assens, Jean Luc Fauchere, Daniel Mettefeu

Publikováno v: Journal of medicinal chemistry. 30(12)

Free-Wilson and correlation analysis were combined to study a series of 34 pepstatin analogues in which mainly position 2 was varied. A statistically highly significant correlation was found between the inhibitory activity of the analogues on an enri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e7cd331b898322648cd1de9affac15c
https://pubmed.ncbi.nlm.nih.gov/3316655

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ChemInform Abstract: STEREOCHEMIE 35. MITT. FLUORIERTE STEROIDE 6. MITT. GERUESTUMLAGERUNG VON ANDROSTEN-(5)-DIOL-(3BETA,17BETA)

Autor: Jean Wagnon, Jacques Levisalles, Jean-Claude Jacquesy

Publikováno v: Chemischer Informationsdienst. Organische Chemie. 1

Bei der Einwirkung von wasserfreier HF auf das Androstendiol (I) entstehen durch Addition das Fluordiol (II) und durch Gerustumlagerung (wahrscheinlich uber (II) als Zwischenstufe) das Ketol (III), das sich sowohl im sauren als auch im alkalischen Me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8bc00a85351db4d7bfaa9b5cc74f8ea4
https://doi.org/10.1002/chin.197026181

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