Výsledky vyhledávání - "Jean, Vizzavona"

BACE1- and BACE2-expressing Human Cells

Autor: Cécile Dumanchin-Njock, David Andrau, Jean-François Hernandez, Erwan Ayral, Michel Boisbrun, Solveig Lefranc-Jullien, Mike Farzan, Jean Martinez, Jean Vizzavona, Pierre Fulcrand, Frédéric Checler

Publikováno v: Journal of Biological Chemistry. 278:25859-25866

We have set up stably transfected HEK293 cells overexpressing the beta-secretases BACE1 and BACE2 either alone or in combination with wild-type beta-amyloid precursor protein (betaAPP). The characterization of the betaAPP-derived catabolites indicate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::af67b1f68565fcbbfd9ae157c98b3eaa
https://doi.org/10.1074/jbc.m302622200

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Covalent capture purification of polypeptides after SPPS via a linker removable under very mild conditions

Autor: Jean Vizzavona, Keith Rose, Matteo Villain

Publikováno v: Tetrahedron Letters. 43:8693-8696

The covalent purification of polypeptides possessing an N-terminal cysteine or threonine residue via formation of a thiazolidine or oxazolidine with an aldehyde-functionalized-resin has been successfully demonstrated. To extend the applicability of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::432fc992b872430b11e33e6b31f7ef27
https://doi.org/10.1016/s0040-4039(02)02110-x

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Stepwise Solid-Phase Synthesis of Polyamides as Linkers

Autor: Jean Vizzavona, Keith Rose

Publikováno v: Journal of the American Chemical Society. 121:7034-7038

Solid-phase peptide synthesis (SPPS) yields well-defined polyamides of repeat unit NH-Z-CO but requires protected derivatives and deprotection steps. Polyamides of repeat unit NH-Y-NH-CO-X-CO (e.g., Nylon 66) are made by polymerizing diacids with dia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f875b56d1c0d811a971dd03fb1f6658e
https://doi.org/10.1021/ja9909879

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Engineering a CD4 mimetic inhibiting the binding of the human immunodeficiency virus-1 (HIV-1) envelope glycoprotein gp120 to human lymphocyte CD4 by the transfer of a CD4 functional site to a small natural scaffold

Autor: Jean Vizzavona, Claudio Vita, Eugenia Drakopoulou

Publikováno v: Letters in Peptide Science. 5:241-245

The solvent-exposed CDR2-like region of human CD4 was transferred to the structural scaffold of scorpion charybdotoxin, as a means to reproduce that site in a native-like conformation. The chimeric mini-protein (33 amino acids long), obtained by soli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fa9a6e2bc5ae452eb6b88113911d8299
https://doi.org/10.1007/bf02443476

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Cathepsin D displays in vitro β-secretase-like specificity

Autor: Claus Peter Baur, Pierre Fulcrand, Jean Vizzavona, Frédéric Checler, Jean Martinez, Nathalie Chevallier, Jean-Pierre Vincent, Michel Goedert, Philippe Marambaud, Maria Grazia Spillantini

Publikováno v: Brain Research. 750:11-19

The formation of A beta and A beta-containing fragments is likely a key event in the process of neural degeneration in Alzheimer's disease. The N-terminal residue (Asp-1) of A beta and its C-terminally extended sequences is liberated from the beta-am

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5abb3f3f8cdf444154acc3bb77126e90
https://doi.org/10.1016/s0006-8993(96)01330-3

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Synthesis and application of an auxiliary group for chemical ligation at the X-gly site

Autor: Fritz Dick, Jean Vizzavona, Thomas Vorherr

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 12:1963-1965

An efficient synthesis of an auxiliary group, the 2-mercapto-4,5-dimethoxybenzyl (Dmmb) moiety, to form a Gly-building block is presented. The building block was incorporated into peptides to study the reaction with thiobenzyl-activated derivatives.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75dfecfa6dce8e2a13b9d9dac203d6d0
https://doi.org/10.1016/s0960-894x(02)00319-0

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Polyethyleneglycol-based chains of precise length for chemobodies

Autor: Keith Rose, Jean Vizzavona

Publikováno v: Peptides for the New Millennium ISBN: 0792364457

When several copies of the same peptide are present in a single multimeric molecule, avidities (and bioactivities) can be greatly enhanced over the affinity or activity of monomeric peptide. Such enhancement (10-fold) occurred with the peptabody [1],

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f826e713dd642cfac6045c8e42f0b012
https://doi.org/10.1007/0-306-46881-6_15

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Rational engineering of a miniprotein inhibitor of HIV-1 infectivity

Autor: Jean Vizzavona, L. Martin, Y.-S. Yang, A. Benjouad, S. Rochette, A. Menez, L. Ylisastigui, C. Roumestand, C. Vita, J.C. Gluckman, E. Drakopoulou

Publikováno v: Peptides for the New Millennium ISBN: 0792364457

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fa96c942814623cfa24615f5dda6faad
https://doi.org/10.1007/0-306-46881-6_205

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BACE1- and BACE2-expressing human cells: characterization of beta-amyloid precursor protein-derived catabolites, design of a novel fluorimetric assay, and identification of new in vitro inhibitors

Autor: David, Andrau, Cecile, Dumanchin-Njock, Erwan, Ayral, Jean, Vizzavona, Mike, Farzan, Michel, Boisbrun, Pierre, Fulcrand, Jean-Francois, Hernandez, Jean, Martinez, Solveig, Lefranc-Jullien, Frederic, Checler

Publikováno v: The Journal of biological chemistry. 278(28)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::25bfaf75629d9531b2ec394720a5f3b2
https://pubmed.ncbi.nlm.nih.gov/12736275

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Synthesis and characterization of biologically functional biotinylated RANTES

Autor: Loyda Ylisastigui, Jean Vizzavona, Jean Claude Gluckman, Marc Parmentier, Loïc Martin, Youssef Bakri, Eugenia Drakopoulou, Claudio Vita, Abdelaziz Benjouad

Publikováno v: Journal of Immunological Methods
Journal of Immunological Methods, Elsevier, 2002, 266 (1-2), pp.53-65. ⟨10.1016/s0022-1759(02)00096-0⟩
Journal of Immunological Methods, 2002, 266 (1-2), pp.53-65. ⟨10.1016/s0022-1759(02)00096-0⟩

International audience; Development of specifically labeled chemokines that retain their biological properties should be useful for analyzing their mechanisms of action both under physiological and pathological conditions. Here, we report the chemica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e890640f8d06cf2013f9b4e96cad773d
https://hal.archives-ouvertes.fr/hal-02528550

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