Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Jean, Vacher"'
Autor:
Miriam E. A. Tschaffon-Müller, Elena Kempter, Lena Steppe, Sandra Kupfer, Melanie R. Kuhn, Florian Gebhard, Carlos Pankratz, Miriam Kalbitz, Konrad Schütze, Harald Gündel, Nele Kaleck, Gudrun Strauß, Jean Vacher, Hiroshi Ichinose, Katja Weimer, Anita Ignatius, Melanie Haffner-Luntzer, Stefan O. Reber
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Mental traumatization is associated with long-bone growth retardation, osteoporosis and increased fracture risk. We revealed earlier that mental trauma disturbs cartilage-to-bone transition during bone growth and repair in mice. Trauma incre
Externí odkaz:
https://doaj.org/article/390d2eb5c5814de9a2dd67dbe9dd90a6
Autor:
Melanie R. Kuhn, Melanie Haffner-Luntzer, Elena Kempter, Stefan O. Reber, Hiroshi Ichinose, Jean Vacher, Anita Ignatius, Miriam E. A. Tschaffon-Müller
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Catecholamine signaling is known to influence bone tissue as reuptake of norepinephrine released from sympathetic nerves into bone cells declines with age leading to osteoporosis. Further, β-adrenoceptor-blockers like propranolol provoke osteoprotec
Externí odkaz:
https://doaj.org/article/c3f9b40511934696ae6cdb532a15acd1
Autor:
Manqi Zhang, Yasemin Ceyhan, Elena M. Kaftanovskaya, Judy L. Vasquez, Jean Vacher, Filip K. Knop, Lubov Nathanson, Alexander I. Agoulnik, Michael M. Ittmann, Irina U. Agoulnik
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
Characterizing mice lacking Inositol Polyphosphate-4-Phosphatase Type II B (INPP4B), Zhang et al. discovered that SREBP1 signaling is activated in livers of Inpp4b −/− males leading to development of NAFLD and insulin resistance. When fed high fa
Externí odkaz:
https://doaj.org/article/c0aa0d8467f04c44b12025eeec6637fa
Publikováno v:
iScience, Vol 25, Iss 4, Pp 104160- (2022)
Summary: Ostm1 mutations cause the severe form of osteopetrosis with bone marrow deficiency in humans and mice, yet a role in T cell ontogeny remains to be determined. Herein, we show that thymi of the Ostm1-null mice (gl/gl) from P8-to-P15 become ma
Externí odkaz:
https://doaj.org/article/1a9c1501204b43fb9a11c6fe232e6d5e
Autor:
Sandi Shen, Mingjue Si, Canjun Zeng, Elaine K. Liu, Yian Chen, Jean Vacher, Haibo Zhao, Subburaman Mohan, Weirong Xing
Publikováno v:
Biology, Vol 12, Iss 4, p 511 (2023)
We previously demonstrated that mice with targeted deletion of the leucine repeat rich kinase 1 (Lrrk1) gene were osteopetrotic due to the failure of osteoclasts to resorb bone. To determine how LRRK1 regulates osteoclast activity, we examined the in
Externí odkaz:
https://doaj.org/article/654079aa2f7849cbb5fe17020796f616
Autor:
Yasemin Ceyhan, Manqi Zhang, Jingtao Guo, Carlos G Sandoval, Jean Vacher, Elena M Kaftanovskaya, Alexander I Agoulnik, Irina U Agoulnik
Publikováno v:
PLoS ONE, Vol 15, Iss 5, p e0233163 (2020)
Inositol polyphosphate-4-phosphatase type II (INPP4B) is a dual-specificity phosphatase that acts as a tumor suppressor in multiple cancers. INPP4B dephosphorylates phospholipids at the 4th position of the inositol ring and inhibits AKT and PKC signa
Externí odkaz:
https://doaj.org/article/757dcc0740e04343a364974fe53c2fec
Autor:
Golam T. Saffi, Cheng An Wang, Emily M. Mangialardi, Jean Vacher, Roberto J. Botelho, Leonardo Salmena
Lysosome membranes contain diverse phosphoinositide (PtdIns) lipids that coordinate lysosome function and dynamics. The PtdIns repertoire on lysosomes is tightly regulated by the actions of diverse PtdIns kinases and phosphatases; however, specific r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dddd8871ec2c1fb356c1cfd1797278c
https://doi.org/10.32920/21982922.v1
https://doi.org/10.32920/21982922.v1
Autor:
Pengyu Zong, Jianlin Feng, Zhichao Yue, Albert S. Yu, Jean Vacher, Evan R. Jellison, Barbara Miller, Yasuo Mori, Lixia Yue
Publikováno v:
Nature cardiovascular research. 1(4)
Atherosclerosis is the major cause of ischemic heart disease and stroke, the leading causes of mortality worldwide. The central pathological features of atherosclerosis include macrophage infiltration and foam cell formation. However, the detailed me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0e05079cec235f22a3cf11eaef4dbb5
https://pubmed.ncbi.nlm.nih.gov/35445217
https://pubmed.ncbi.nlm.nih.gov/35445217
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0157441 (2016)
Biodiversity loss and climate change are both globally significant issues that must be addressed through collaboration across countries and disciplines. With the December 2015 COP21 climate conference in Paris and the recent creation of the Intergove
Externí odkaz:
https://doaj.org/article/6ab5e8b3313b49e0975b860b1996a488
Lysosome membranes contain diverse phosphoinositide (PtdIns) lipids that co-ordinate lysosome function and dynamics. The PtdIns repertoire on lysosomes is tightly regulated by the action of diverse PtdIns kinases and phosphatases. Specific roles for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a0298f44f0a3ba9a62c6ab6eb0d42ef
https://doi.org/10.1101/2021.12.13.472440
https://doi.org/10.1101/2021.12.13.472440