Neuroimaging-based classification of PTSD using data-driven computational approaches: A multisite big data study from the ENIGMA-PGC PTSD consortium

Autor: Xi Zhu, Yoojean Kim, Orren Ravid, Xiaofu He, Benjamin Suarez-Jimenez, Sigal Zilcha-Mano, Amit Lazarov, Seonjoo Lee, Chadi G. Abdallah, Michael Angstadt, Christopher L. Averill, C. Lexi Baird, Lee A. Baugh, Jennifer U. Blackford, Jessica Bomyea, Steven E. Bruce, Richard A. Bryant, Zhihong Cao, Kyle Choi, Josh Cisler, Andrew S. Cotton, Judith K. Daniels, Nicholas D. Davenport, Richard J. Davidson, Michael D. DeBellis, Emily L. Dennis, Maria Densmore, Terri deRoon-Cassini, Seth G. Disner, Wissam El Hage, Amit Etkin, Negar Fani, Kelene A. Fercho, Jacklynn Fitzgerald, Gina L. Forster, Jessie L. Frijling, Elbert Geuze, Atilla Gonenc, Evan M. Gordon, Staci Gruber, Daniel W Grupe, Jeffrey P. Guenette, Courtney C. Haswell, Ryan J. Herringa, Julia Herzog, David Bernd Hofmann, Bobak Hosseini, Anna R. Hudson, Ashley A. Huggins, Jonathan C. Ipser, Neda Jahanshad, Meilin Jia-Richards, Tanja Jovanovic, Milissa L. Kaufman, Mitzy Kennis, Anthony King, Philipp Kinzel, Saskia B.J. Koch, Inga K. Koerte, Sheri M. Koopowitz, Mayuresh S. Korgaonkar, John H. Krystal, Ruth Lanius, Christine L. Larson, Lauren A.M. Lebois, Gen Li, Israel Liberzon, Guang Ming Lu, Yifeng Luo, Vincent A. Magnotta, Antje Manthey, Adi Maron-Katz, Geoffery May, Katie McLaughlin, Sven C. Mueller, Laura Nawijn, Steven M. Nelson, Richard W.J. Neufeld, Jack B Nitschke, Erin M. O'Leary, Bunmi O. Olatunji, Miranda Olff, Matthew Peverill, K. Luan Phan, Rongfeng Qi, Yann Quidé, Ivan Rektor, Kerry Ressler, Pavel Riha, Marisa Ross, Isabelle M. Rosso, Lauren E. Salminen, Kelly Sambrook, Christian Schmahl, Martha E. Shenton, Margaret Sheridan, Chiahao Shih, Maurizio Sicorello, Anika Sierk, Alan N. Simmons, Raluca M. Simons, Jeffrey S. Simons, Scott R. Sponheim, Murray B. Stein, Dan J. Stein, Jennifer S. Stevens, Thomas Straube, Delin Sun, Jean Théberge, Paul M. Thompson, Sophia I. Thomopoulos, Nic J.A. van der Wee, Steven J.A. van der Werff, Theo G.M. van Erp, Sanne J.H. van Rooij, Mirjam van Zuiden, Tim Varkevisser, Dick J. Veltman, Robert R.J.M. Vermeiren, Henrik Walter, Li Wang, Xin Wang, Carissa Weis, Sherry Winternitz, Hong Xie, Ye Zhu, Melanie Wall, Yuval Neria, Rajendra A. Morey

Publikováno v: NeuroImage, Vol 283, Iss , Pp 120412- (2023)

Background: Recent advances in data-driven computational approaches have been helpful in devising tools to objectively diagnose psychiatric disorders. However, current machine learning studies limited to small homogeneous samples, different methodolo

Externí odkaz: https://doaj.org/article/064745d8320544298a997782e36ec231

Microstructural imaging and transcriptomics of the basal forebrain in first-episode psychosis

Autor: Min Tae M. Park, Peter Jeon, Leon French, Kara Dempster, M. Mallar Chakravarty, Michael MacKinley, Julie Richard, Ali R. Khan, Jean Théberge, Lena Palaniyappan

Publikováno v: Translational Psychiatry, Vol 12, Iss 1, Pp 1-11 (2022)

Abstract Cholinergic dysfunction has been implicated in the pathophysiology of psychosis and psychiatric disorders such as schizophrenia, depression, and bipolar disorder. The basal forebrain (BF) cholinergic nuclei, defined as cholinergic cell group

Externí odkaz: https://doaj.org/article/d14bf40211984453ab21fc97b6dac7b4

How the body remembers: Examining the default mode and sensorimotor networks during moral injury autobiographical memory retrieval in PTSD

Autor: Breanne E. Kearney, Braeden A. Terpou, Maria Densmore, Saurabh B. Shaw, Jean Théberge, Rakesh Jetly, Margaret C. McKinnon, Ruth A. Lanius

Publikováno v: NeuroImage: Clinical, Vol 38, Iss , Pp 103426- (2023)

Neural representations of sensory percepts and motor responses constitute key elements of autobiographical memory. However, these representations may remain as unintegrated sensory and motor fragments in traumatic memory, thus contributing toward re-

Externí odkaz: https://doaj.org/article/a4ce4cb9cd40455faa56470d4e15daac

Widespread cortical thinning, excessive glutamate and impaired linguistic functioning in schizophrenia: A cluster analytic approach

Autor: Liangbing Liang, Angélica M. Silva, Peter Jeon, Sabrina D. Ford, Michael MacKinley, Jean Théberge, Lena Palaniyappan

Publikováno v: Frontiers in Human Neuroscience, Vol 16 (2022)

IntroductionSymptoms of schizophrenia are closely related to aberrant language comprehension and production. Macroscopic brain changes seen in some patients with schizophrenia are suspected to relate to impaired language production, but this is yet t

Externí odkaz: https://doaj.org/article/1d8c629b3bb844648a3a992a2d006a12

Contrasting Associations Between Heart Rate Variability and Brainstem-Limbic Connectivity in Posttraumatic Stress Disorder and Its Dissociative Subtype: A Pilot Study

Autor: Janine Thome, Maria Densmore, Braeden A. Terpou, Jean Théberge, Margaret C. McKinnon, Ruth A. Lanius

Publikováno v: Frontiers in Behavioral Neuroscience, Vol 16 (2022)

BackgroundIncreasing evidence points toward the need to extend the neurobiological conceptualization of posttraumatic stress disorder (PTSD) to include evolutionarily conserved neurocircuitries centered on the brainstem and the midbrain. The reticula

Externí odkaz: https://doaj.org/article/cbbabb7af7d7474e887ed48043aa0a1d