Výsledky vyhledávání - "Jean, De Vry"

Synergistic interaction between the agonism of cebranopadol at nociceptin/orphanin FQ and classical opioid receptors in the rat spinal nerve ligation model

Autor: Wolfgang P. Schröder, Thomas Christoph, Jean De Vry, Robert B. Raffa

Publikováno v: Pharmacology Research & Perspectives

Cebranopadol (trans‐6′‐fluoro‐4′,9′‐dihydro‐N,N‐dimethyl‐4‐phenyl‐spiro[cyclohexane‐1,1′(3′H)‐pyrano[3,4‐b]indol]‐4‐amine) is a novel analgesic nociceptin/orphanin FQ opioid peptide (NOP) and classical opioid rec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e107c4baa57898f653a920a5c0e811c9
https://pubmed.ncbi.nlm.nih.gov/30519474

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Cebranopadol: A Novel Potent Analgesic Nociceptin/Orphanin FQ Peptide and Opioid Receptor Agonist

Autor: Thomas M. Tzschentke, Michael Gautrois, Wolfgang P. Schröder, Stefan Schunk, Werner Englberger, Horst Beier, Thomas Christoph, Klaus Schiene, Jean De Vry, Thomas Koch, Babette Kögel, Ulrich Jahnel, Klaus Linz, Stefanie Frosch

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 349:535-548

Cebranopadol (trans-6'-fluoro-4',9'-dihydro-N,N-dimethyl-4-phenyl-spiro[cyclohexane-1,1'(3'H)-pyrano[3,4-b]indol]-4-amine) is a novel analgesic nociceptin/orphanin FQ peptide (NOP) and opioid receptor agonist [Ki (nM)/EC50 (nM)/relative efficacy (%):

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0031d5a8a624f155ce9156d82b5170d
https://doi.org/10.1124/jpet.114.213694

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Pharmacological and behavioral profile of N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-6-chinolincarboxamide (EVP-5141), a novel α7 nicotinic acetylcholine receptor agonist/serotonin 5-HT3 receptor antagonist

Autor: Christina Erb, Marja Van Kampen, Welf-Burkhard Wiese, Frank G. Boess, Jean De Vry, Gerhard Konig, Christoph Methfessel, Katrin Schnizler, Joachim Luithle, F. Josef van der Staay, Timo Flessner, Martin Hendrix

Publikováno v: Psychopharmacology, 227, 1. Springer Verlag

Agonists of α7 nicotinic acetylcholine receptors (nAChRs) may have therapeutic potential for the treatment of cognitive deficits. This study describes the in vitro pharmacology of the novel α7 nAChR agonist/serotonin 5-HT3 receptor (5-HT3R) antagon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d5fc7228e1b352e966a840d738e248a
https://doi.org/10.1007/s00213-012-2933-4

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Tapentadol increases levels of noradrenaline in the rat spinal cord as measured by in vivo microdialysis

Autor: Jean De Vry, Joost H.A. Folgering, Thomas M. Tzschentke, Gunnar Flik

Publikováno v: Neuroscience Letters. 507:151-155

Spinal noradrenaline is thought to play an important role in descending pain inhibitory pathways and the modulation of nociceptive information at the spinal level. Tapentadol is a μ-opioid receptor (MOR) agonist and noradrenaline reuptake inhibitor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e96ea81a81f4fe48a2727fd7341aa04
https://doi.org/10.1016/j.neulet.2011.12.008

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Synergistic antihypersensitive effects of pregabalin and tapentadol in a rat model of neuropathic pain

Autor: Klaus Schiene, Ronald J. Tallarida, Thomas Christoph, Thomas M. Tzschentke, Jean De Vry

Publikováno v: European Journal of Pharmacology. 666:72-79

Neuropathic pain is a clinical condition which remains poorly treated and combinations of pregabalin, an antagonist of the α2δ-subunit of Ca(2+) channels, with tapentadol, a μ-opioid receptor agonist/noradrenaline reuptake inhibitor, or with class

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51220ec0436e26de85a18fd20dc68d74
https://doi.org/10.1016/j.ejphar.2011.05.029

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Critical Evaluation of the Use of Extinction Paradigms for the Assessment of Opioid-Induced Conditioned Place Preference in Rats

Autor: Kris Rutten, Thomas M. Tzschentke, Elizabeth L. van der Kam, Jean De Vry

Publikováno v: Pharmacology. 87:286-296

The rewarding effects of drugs of abuse are often studied by means of the conditioned place preference (CPP) paradigm. CPP is one of the most widely used models in behavioral pharmacology, yet its theoretical underpinnings are not well understood, an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ce8d1afe7820982e3a3b86c5161863f
https://doi.org/10.1159/000327680

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The mGluR5 antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) potentiates conditioned place preference induced by various addictive and non-addictive drugs in rats

Autor: Jean De Vry, Walter Bruckmann, Thomas M. Tzschentke, Kris Rutten, Elizabeth L. van der Kam

Publikováno v: Addiction Biology. 16:108-115

We have recently reported that the metabotropic glutamate receptor 5 antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) potentiates acquisition of conditioned place preference (CPP) induced by heroin and ketamine. The present study investigated to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bfce153a941ca082da7eed3cacdfc6fa
https://doi.org/10.1111/j.1369-1600.2010.00235.x

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Effects of the NOP receptor agonist Ro65-6570 on the acquisition of opiate- and psychostimulant-induced conditioned place preference in rats

Autor: Walter Bruckmann, Jean De Vry, Thomas M. Tzschentke, Kris Rutten

Publikováno v: European Journal of Pharmacology. 645:119-126

Activation of the Nociceptin/Orphanin FQ (NOP) receptor may have anti-abuse effects. The present study examined the consequence of NOP receptor activation on the rewarding effect of opiates and psychostimulants in the conditioned place preference tas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39a1b3be3c098fe19a9908312bd7b9b6
https://doi.org/10.1016/j.ejphar.2010.07.036

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Differential contribution of opioid and noradrenergic mechanisms of tapentadol in rat models of nociceptive and neuropathic pain

Autor: Ulrich Jahnel, Thomas Christoph, Jean De Vry, Thomas M. Tzschentke, Wolfgang P. Schröder

Publikováno v: European Journal of Pain. 14:814-821

The novel analgesic tapentadol combines μ-opioid receptor agonism and noradrenaline reuptake inhibition in a single molecule and shows potent analgesia in various rodent models of pain. We analyzed the contribution of opioid and monoaminergic mechan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2af35e22a84c4f2dd1a8651481263b5c
https://doi.org/10.1016/j.ejpain.2010.05.005

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