Involvement of epigenetic modification of TERT promoter in response to all-trans retinoic acid in ovarian cancer cell lines

Autor: Lorena Losi, Angela Lauriola, Erica Tazzioli, Gaia Gozzi, Letizia Scurani, Domenico D’Arca, Jean Benhattar

Publikováno v: Journal of Ovarian Research, Vol 12, Iss 1, Pp 1-10 (2019)

Abstract Background All-trans retinoic acid (ATRA) is currently being used to treat hematological malignancies, given the ability to inhibit cell proliferation. This effect seems to be related to epigenetic changes of the TERT (Telomerase Reverse Tra

Externí odkaz: https://doaj.org/article/8f66113f4e574bcb89d0e32fbb21bc0a

High expression of hTERT and stemness genes in BORIS/CTCFL positive cells isolated from embryonic cancer cells.

Autor: Loredana Alberti, Stéphanie Renaud, Lorena Losi, Serge Leyvraz, Jean Benhattar

Publikováno v: PLoS ONE, Vol 9, Iss 10, p e109921 (2014)

BORIS/CTCFL is a member of cancer testis antigen family normally expressed in germ cells. In tumors, it is aberrantly expressed although its functions are not completely well-defined. To better understand the functions of BORIS in cancer, we selected

Externí odkaz: https://doaj.org/article/459da0561b4547068e5da0089aa656f0

TERT promoter methylation and protein expression as predictive biomarkers for recurrence risk in patients with serous borderline ovarian tumours

Autor: Lorena Losi, Rossana Panini, Graziana Gallo, Laura Botticelli, Jean Benhattar, Lorella Garagnani, Antonino Maiorana, Luca Fabbiani, Roberto Sabbatini

Publikováno v: Pathology. 53(2)

Epithelial ovarian neoplasms can be divided into three distinct clinicopathological groups: benign, malignant and borderline tumours. Borderline tumours are less aggressive than epithelial carcinomas, with an indolent clinical course and delayed recu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2be393a419241fefd7f918cd937e3cf9
https://pubmed.ncbi.nlm.nih.gov/33032810

Involvement of epigenetic modification of TERT promoter in response to all-trans retinoic acid in ovarian cancer cell lines

Autor: Jean Benhattar, Erica Tazzioli, Domenico D'Arca, Gaia Gozzi, Lorena Losi, Letizia Scurani, Angela Lauriola

Publikováno v: Journal of ovarian research, vol. 12, no. 1, pp. 62
Journal of Ovarian Research, Vol 12, Iss 1, Pp 1-10 (2019)
Journal of Ovarian Research

Background All-trans retinoic acid (ATRA) is currently being used to treat hematological malignancies, given the ability to inhibit cell proliferation. This effect seems to be related to epigenetic changes of the TERT (Telomerase Reverse Transcriptas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::852c683dcd2690d3b56e84a6f07ed85a
https://serval.unil.ch/notice/serval:BIB_799FEF056257

Distinct DNA Methylation Profiles in Ovarian Tumors: Opportunities for Novel Biomarkers

Autor: Sonia T. Chelbi, Cesare Lancellotti, Luca Fabbiani, Gaia Gozzi, Lorena Losi, Sergio Fonda, Loredana Alberti, Laura Botticelli, Jean Benhattar, Sara Saponaro

Publikováno v: International Journal of Molecular Sciences
International journal of molecular sciences, vol. 19, no. 6, pp. 1559
International Journal of Molecular Sciences; Volume 19; Issue 6; Pages: 1559
International Journal of Molecular Sciences, Vol 19, Iss 6, p 1559 (2018)

Aberrant methylation of multiple promoter CpG islands could be related to the biology of ovarian tumors and its determination could help to improve treatment strategies. DNA methylation profiling was performed using the Methylation Ligation-dependent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::322c7bf1c850925a779f3c9fb7bdcb63
http://europepmc.org/articles/PMC6032431