Zobrazeno 1 - 10
of 313
pro vyhledávání: '"Jeak Ling Ding"'
Autor:
Darren Chen Pei Wong, E Hui Clarissa Lee, Junzhi Er, Ivan Yow, Ricky Abdi Gunawan Koean, Owen Ang, Jingwei Xiao, Boon Chuan Low, Jeak Ling Ding
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Actomyosin-mediated cellular contractility is highly conserved for mechanotransduction and signalling. While this phenomenon has been observed in adherent cell models, whether/how contractile forces regulate the function of suspension cells like natu
Externí odkaz:
https://doaj.org/article/53f5af9143e847cd8afaa3e374aec0f3
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Natural killer (NK) cells are innate immune cells which play a key role in shaping the immune response against cancer. Initially hailed for their potential to recognise and eliminate tumour cells, their application has been greatly hindered by the im
Externí odkaz:
https://doaj.org/article/5d3b8a918750451ca9165f2ed14d1401
Autor:
Riva Verma, Jun Zhi Er, Ren Wei Pu, Jameelah Sheik Mohamed, Ross A. Soo, Harish Mithiran Muthiah, John Kit Chung Tam, Jeak Ling Ding
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Recent studies have attempted to uncover the role of Group 1 Innate lymphoid cells (ILCs) in multiple physiological contexts, including cancer. However, the definition and precise contribution of Group 1 ILCs (constituting ILC1 and NK subsets) to met
Externí odkaz:
https://doaj.org/article/a7056f854d414aecaa01f274ff017b2c
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 8 (2020)
Even under normoxia, cancer cells exhibit increased glucose uptake and glycolysis, an occurrence known as the Warburg effect. This altered metabolism results in increased lactic acid production, leading to extracellular acidosis and contributing to m
Externí odkaz:
https://doaj.org/article/9da69e181bf14893b6484c2bf83f3f6a
Autor:
Lei Yang, Jeak Ling Ding
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Macrophages are immune sentinels essential for pathogen recognition and immune defense. Nucleic acid-sensing toll-like receptors like TLR7 activate tailored proinflammatory and interferon responses in macrophages. Here we found that TLR7 activation c
Externí odkaz:
https://doaj.org/article/6581717ef00f482694d7c4841c0653ba
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Monocytes are a subset of cells that are categorized together with dendritic cells (DCs) and macrophages in the mononuclear phagocyte system (MPS). Despite sharing several phenotypic and functional characteristics with MPS cells, monocytes are unique
Externí odkaz:
https://doaj.org/article/41c2bd77b64c4484b721f4cfad88f6d9
Autor:
Zhiwei Ang, Ricky Abdi Gunawan Koean, Jun Zhi Er, Li Ting Lee, John Kit Chung Tam, Huili Guo, Jeak Ling Ding
Publikováno v:
PLoS Genetics, Vol 15, Iss 4, p e1008077 (2019)
The role of ribosomal protein S6 (rpS6) phosphorylation in mRNA translation remains poorly understood. Here, we reveal a potential role in modulating the translation rate of chemokine (C-X-C motif) ligand 8 (CXCL8 or Interleukin 8, IL8). We observed
Externí odkaz:
https://doaj.org/article/ef66d414a8e24aeb9831bec48e6e86f4
Autor:
Shu-Chun Chang, Bo-Xiang Zhang, Emily Chia-Yu Su, Wei-Ciao Wu, Tsung-Han Hsieh, Andres M. Salazar, Yen-Kuang Lin, Jeak Ling Ding
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 4, p 1626 (2021)
NSCLC (non-small cell lung cancer) is a leading cause of cancer-related deaths worldwide. Clinical trials showed that Hiltonol, a stable dsRNA representing an advanced form of polyI:C (polyinosinic-polycytidilic acid), is an adjuvant cancer-immunomod
Externí odkaz:
https://doaj.org/article/2a4abc3ecc7345b096b74decdd48b3ed
Publikováno v:
EBioMedicine, Vol 2, Iss 3, Pp 225-233 (2015)
Background: Haemolytic infection lyses red blood cells, releasing haemoglobin (Hb) into the plasma. Although recent studies showed that immune cells recognize redox-active cytotoxic extracellular Hb (metHb) bound to pathogen-associated molecular patt
Externí odkaz:
https://doaj.org/article/62f9fdb5f5af4345af2ac7b4d3b8da8e
Autor:
Emil Carlsson, Joanne E Thwaite, Dominic C Jenner, Abigail M Spear, Helen Flick-Smith, Helen S Atkins, Bernadette Byrne, Jeak Ling Ding
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0158575 (2016)
Toll-like receptors (TLRs) recognise invading pathogens and mediate downstream immune signalling via Toll/IL-1 receptor (TIR) domains. TIR domain proteins (Tdps) have been identified in multiple pathogenic bacteria and have recently been implicated a
Externí odkaz:
https://doaj.org/article/8f660a7c204144b4a51f1b89da4b7647