Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Je-Nie Phue"'
Autor:
Peter Radvak, Hyung-Joon Kwon, Martina Kosikova, Uriel Ortega-Rodriguez, Ruoxuan Xiang, Je-Nie Phue, Rong-Fong Shen, James Rozzelle, Neeraj Kapoor, Taylor Rabara, Jeff Fairman, Hang Xie
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Mutant SARS-CoV-2 strains such as B.1.1.7 and B.1.351 have been termed variants of concerns (VoC) due to their enhanced virulence. Here the authors show, using K18-hACE2 transgenic mouse models, that these two VoCs are also more pathogenic in mice, a
Externí odkaz:
https://doaj.org/article/b798cec113434016bcaf2b4323e29ab0
Autor:
Xiaoping Sun, Thomas Nguyen, Achouak Achour, Annette Ko, Jeffrey Cifello, Chen Ling, Jay Sharma, Toyoko Hiroi, Yongqing Zhang, Chee W. Chia, William Wood III, Wells W. Wu, Linda Zukley, Je-Nie Phue, Kevin G. Becker, Rong-Fong Shen, Luigi Ferrucci, Nan-ping Weng
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 17 (2022)
A diverse T cell receptor (TCR) repertoire is essential for protection against a variety of pathogens, and TCR repertoire size is believed to decline with age. However, the precise size of human TCR repertoires, in both total and subsets of T cells,
Externí odkaz:
https://doaj.org/article/be9e3fbb629f4693b28c5ccd2679bf6e
Autor:
Erica McGrath, Hyunsu Shin, Linyi Zhang, Je-Nie Phue, Wells W. Wu, Rong-Fong Shen, Yoon-Young Jang, Javier Revollo, Zhaohui Ye
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
Cytidine base editors are powerful tools for making subtle genome alterations. Here the authors analyse edited human iPSCs with whole genome sequencing and reveal the spectrum of off-target effects.
Externí odkaz:
https://doaj.org/article/af712862da014df4afe9e07f5f556c66
Autor:
Lai Xu, Helen Luo, Rong Wang, Wells W. Wu, Je-Nie Phue, Rong-Fong Shen, Hartmut Juhl, Leihong Wu, Wei-lun Alterovitz, Vahan Simonyan, Lorraine Pelosof, Amy S. Rosenberg
Publikováno v:
BMC Medical Genetics, Vol 20, Iss 1, Pp 1-13 (2019)
Abstract Background Reference genes are often interchangeably called housekeeping genes due to 1) the essential cellular functions their proteins provide and 2) their constitutive expression across a range of normal and pathophysiological conditions.
Externí odkaz:
https://doaj.org/article/4139dfba11ea48ae9b6493a2f0e9f38d
Autor:
Lai Xu, Lorraine Pelosof, Rong Wang, Hugh I. McFarland, Wells W. Wu, Je-Nie Phue, Chun-Ting Lee, Rong-Fong Shen, Hartmut Juhl, Lei-Hong Wu, Wei-Lun Alterovitz, Emanuel Petricon, Amy S. Rosenberg
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
To evaluate the expression of immune checkpoint genes, their concordance with expression of IFNγ, and to identify potential novel ICP related genes (ICPRG) in colorectal cancer (CRC), the biological connectivity of six well documented (“classical
Externí odkaz:
https://doaj.org/article/3f067d4684b54e6e887a0e30459c6914
Autor:
Wells W. Wu, Je-Nie Phue, Chun-Ting Lee, Changyi Lin, Lai Xu, Rong Wang, Yaqin Zhang, Rong-Fong Shen
Publikováno v:
BMC Genomics, Vol 19, Iss 1, Pp 1-10 (2018)
Abstract Background Current library preparation protocols for Illumina HiSeq and MiSeq DNA sequencers require ≥2 nM initial library for subsequent loading of denatured cDNA onto flow cells. Such amounts are not always attainable from samples having
Externí odkaz:
https://doaj.org/article/4ed2709f68ab46d89809b8cb8c9ea9ac
Autor:
Vivienne Edwards, Dylan L. Smith, Francoise Meylan, Linda Tiffany, Sarah Poncet, Wells W. Wu, Je-Nie Phue, Luis Santana-Quintero, Kathleen A. Clouse, Odile Gabay
Publikováno v:
Microorganisms, Vol 10, Iss 1, p 73 (2021)
Very little is known about disease transmission via the gut microbiome. We hypothesized that certain inflammatory features could be transmitted via the gut microbiome and tested this hypothesis using an animal model of inflammatory diseases. Twelve-w
Externí odkaz:
https://doaj.org/article/77d7967ba7f449dd8307aa062beac131
Autor:
Gabriel Silva, Mozart Marins, Nadda Chaichanasak, Yongdae Yoon, Ana Lúcia Fachin, Vitor Caressato Pinhanelli, Luis Octávio Regasini, Mariana Bastos Dos Santos, Gabriela Miranda Ayusso, Beatriz de Carvalho Marques, Wells W Wu, Je-Nie Phue, Rong-Fong Shen, Seung Joon Baek
Publikováno v:
PLoS ONE, Vol 13, Iss 8, p e0202263 (2018)
Naturally-occurring chalcones and synthetic chalcone analogues have been demonstrated to have many biological effects, including anti-inflammatory, anti-malarial, anti-fungal, and anti-oxidant/anti-cancerous activities. Compared to other chalcones, t
Externí odkaz:
https://doaj.org/article/c4a2f866cc5149068acd7afa844eeab7
Autor:
Neeraj Kapoor, Peter Radvak, Martina Kosikova, Hang Xie, Uriel Ortega-Rodriguez, James Rozzelle, Je-Nie Phue, Ruoxuan Xiang, Hyung-Joon Kwon, Rong-Fong Shen, Jeff Fairman, Taylor Rabara
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
Nature Communications
SARS-CoV-2 variants of concern (VOC) B.1.1.7 (alpha) and B.1.351 (beta) show increased transmissibility and enhanced antibody neutralization resistance. Here we demonstrate in K18-hACE2 transgenic mice that B.1.1.7 and B.1.351 are 100-fold more letha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a80728246c01866513a44a69dfa9bcc
https://doaj.org/article/b798cec113434016bcaf2b4323e29ab0
https://doaj.org/article/b798cec113434016bcaf2b4323e29ab0
Publikováno v:
Microbiology (Reading)
Successful adaptation of Escherichia coli to constant environmental challenges demands the operation of a wide range of regulatory control mechanisms, some of which are global, while others are specific. Here, we show that the ability of acetate-nega
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06cdf9c460740fa3b0b52a63903145be
https://doi.org/10.1099/mic.0.001230
https://doi.org/10.1099/mic.0.001230