Anisotropic scrunching of SMC with a baton-pass mechanism

Autor: Kyoung-Wook Moon, Do-Gyun Kim, Je-Kyung Ryu

Publikováno v: Communications Biology, Vol 7, Iss 1, Pp 1-7 (2024)

Abstract DNA-loop extrusion is considered to be a universal principle of structural maintenance of chromosome (SMC) proteins with regard to chromosome organization. Despite recent advancements in structural dynamics studies that involve the use of cr

Externí odkaz: https://doaj.org/article/09bfe8a93f9945e59d8120086792015a

Requirement of Cholesterol for Calcium‐Dependent Vesicle Fusion by Strengthening Synaptotagmin‐1‐Induced Membrane Bending

Autor: Houda Yasmine Ali Moussa, Kyung Chul Shin, Janarthanan Ponraj, Soo Jin Kim, Je‐Kyung Ryu, Said Mansour, Yongsoo Park

Publikováno v: Advanced Science, Vol 10, Iss 15, Pp n/a-n/a (2023)

Abstract Cholesterol is essential for neuronal activity and function. Cholesterol depletion in the plasma membrane impairs synaptic transmission. However, the molecular mechanisms by which cholesterol deficiency leads to defects in vesicle fusion rem

Externí odkaz: https://doaj.org/article/0e95e918cd144211861af4070419af05

Current Understanding of Molecular Phase Separation in Chromosomes

Autor: Je-Kyung Ryu, Da-Eun Hwang, Jeong-Mo Choi

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 19, p 10736 (2021)

Biomolecular phase separation denotes the demixing of a specific set of intracellular components without membrane encapsulation. Recent studies have found that biomolecular phase separation is involved in a wide range of cellular processes. In partic

Externí odkaz: https://doaj.org/article/ca4a54eee1f142d68d964fa96a8ee23d

Requirement of cholesterol for calcium-dependent vesicle fusion by stabilizing synaptotagmin-1-induced membrane bending

Autor: Houda Yasmine Ali Moussa, Kyung Chul Shin, Janarthanan Ponraj, Soo Jin Kim, Je-Kyung Ryu, Said Mansour, Yongsoo Park

Cholesterol is essential for neuronal activity and function. Cholesterol depletion in the plasma membrane impairs synaptic transmission. However, the molecular mechanisms by which cholesterol deficiency leads to defects in vesicle fusion remain poorl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aea1f1aa7b836f44035d533d4872a1de
https://doi.org/10.21203/rs.3.rs-1313659/v2

Condensin extrudes DNA loops in steps up to hundreds of base pairs that are generated by ATP binding events

Autor: Jacob W. J. Kerssemakers, Sang-Hyun Rah, Richard Janissen, Je-Kyung Ryu, Davide Michieletto, Cees Dekker, Andrea Bonato

Publikováno v: Ryu, J-K, Rah, S-H, Janissen, R, Kerssemakers, J W J, Bonato, A, Michieletto, D & Dekker, C 2022, ' Condensin extrudes DNA loops in steps up to hundreds of base pairs that are generated by ATP binding events ', Nucleic Acids Research, vol. 50, no. 2, pp. 820-832 . https://doi.org/10.1093/nar/gkab1268
Nucleic acids research, 50(2)
Nucleic Acids Research
bioRxiv
Nucl. Acid Res. 50

The condensin SMC protein complex organizes chromosomal structure by extruding loops of DNA. Its ATP-dependent motor mechanism remains unclear but likely involves steps associated with large conformational changes within the ∼50 nm protein complex.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b589d734e704ed6b5292c013bcddcc0e
https://www.pure.ed.ac.uk/ws/files/261761699/gkab1268.pdf