Association of vitamin D status with arterial blood pressure and hypertension risk: a mendelian randomisation study

Autor: Ks, Vimaleswaran, Cavadino A, Dj, Berry, LifeLines Cohort Study investigators, Jorde R, Ak, Dieffenbach, Lu C, Ac, Alves, Hj, Heerspink, Tikkanen E, Eriksson J, Wong A, Mangino M, Ka, Jablonski, Im, Nolte, Dk, Houston, Ts, Ahluwalia, Pj, Most, Pasko D, Zgaga L, Thiering E, Vitart V, Rm, Fraser, Je, Huffman, Ra, Boer, Schöttker B, Ku, Saum, Mi, Mccarthy, Dupuis J, Kh, Herzig, Sebert S, Pouta A, Laitinen J, Me, Kleber, Navis G, Lorentzon M, Jameson K, Arden N, Ja, Cooper, Acharya J, Hardy R, Raitakari O, Ripatti S, Lk, Billings, Lahti J, Osmond C, Bw, Penninx, Rejnmark L, Kk, Lohman, Paternoster L, Rp, Stolk, Dg, Hernandez, Byberg L, Hagström E, Melhus H, Ingelsson E, Mellström D, Ljunggren O, Tzoulaki I, McLachlan S, Theodoratou E, Cm, Tiesler, Jula A, Navarro P, Af, Wright, Polasek O, International Consortium for Blood Pressure (ICBP), Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium, Global Blood Pressure Genetics (Global BPGen) consortium, Caroline Hayward, Jf, Wilson, Rudan I, Salomaa V, Heinrich J, Campbell H, Jf, Price, Karlsson M, Lind L, Michaëlsson K, Bandinelli S, Tm, Frayling, Ca, Hartman, Ti, Sørensen, Sb, Kritchevsky, Bl, Langdahl, Jg, Eriksson, Jc, Florez, Td, Spector, Lehtimäki T, Kuh D, Se, Humphries, Cooper C, Ohlsson C, März W, Mh, Borst, Kumari M, Mika Kivimaki, Tj, Wang, Power C, Brenner H, Grimnes G, van der Harst P, Snieder H, Ad, Hingorani, Pilz S, Jc, Whittaker, Järvelin MR, Hyppönen E

Publikováno v: Europe PubMed Central

BACKGROUND: Low plasma 25-hydroxyvitamin D (25[OH]D) concentration is associated with high arterial blood pressure and hypertension risk, but whether this association is causal is unknown. We used a mendelian randomisation approach to test whether 25

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::425db1caf29762d177e8497e030e1999
https://researchonline.lshtm.ac.uk/id/eprint/1878076/1/NIHMS721970-supplement-Supplementary_Appendix.pdf

The Use of Ground Vulcanized Rubber in Asphalt

Autor: JE Huffman

In the early 1960's a concept was developed in Arizona primarily to overcome the problem of the early reflection of fatigue cracking in asphalt pavements. The concept was based on a composite material of asphalt cement and a high percentage of ground

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1be42f828b82fa19667baacd8b79738a
https://doi.org/10.1520/stp38361s

Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function

Autor: Soler Artigas M, Dw, Loth, Lv, Wain, Sa, Gharib, Obeidat M, Tang W, Zhai G, Jh, Zhao, Av, Smith, Je, Huffman, Albrecht E, Cm, Jackson, Dm, Evans, Cadby G, Md, Tobin

Publikováno v: Europe PubMed Central

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::4ca1cc8fb6ef3ea02043db674769307f
http://europepmc.org/abstract/med/21946350

Publisher Correction: Genome-wide association study reveals mechanisms underlying dilated cardiomyopathy and myocardial resilience.

Autor: Jurgens SJ; Department of Experimental Cardiology, Amsterdam Cardiovascular Sciences, Heart Failure & Arrhythmias, Amsterdam UMC location, University of Amsterdam, Amsterdam, the Netherlands.; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA., Rämö JT; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.; Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland., Kramarenko DR; Department of Experimental Cardiology, Amsterdam Cardiovascular Sciences, Heart Failure & Arrhythmias, Amsterdam UMC location, University of Amsterdam, Amsterdam, the Netherlands.; European Reference Network for rare low prevalence and complex diseases of the heart: ERN GUARD-Heart, Amsterdam, the Netherlands., Wijdeveld LFJM; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Physiology, Amsterdam UMC location, Vrije Universiteit, Amsterdam, the Netherlands., Haas J; Department of Medicine III, Institute for Cardiomyopathies Heidelberg (ICH), University Hospital Heidelberg, Heidelberg, Germany.; Site Heidelberg/Mannheim, DZHK, Heidelberg, Germany., Chaffin MD; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Garnier S; Research Unit on Cardiovascular Disorders, Metabolism and Nutrition, Team Genomics and Pathophysiology of Cardiovascular Disease, Sorbone Université, INSERM, Paris, France.; ICAN Institute for Cardiometabolism and Nutrition, Paris, France., Gaziano L; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA., Weng LC; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA., Lipov A; Department of Experimental Cardiology, Amsterdam Cardiovascular Sciences, Heart Failure & Arrhythmias, Amsterdam UMC location, University of Amsterdam, Amsterdam, the Netherlands., Zheng SL; National Heart and Lung Institute, Imperial College London, London, UK.; MRC Laboratory of Medical Sciences, Imperial College London, London, UK.; Royal Brompton and Harefield Hospitals, Guy's and St. Thomas' NHS Foundation Trust, London, UK., Henry A; Institute of Cardiovascular Science, University College London, London, UK.; Institute of Health Informatics, University College London, London, UK., Huffman JE; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.; Palo Alto Veterans Institute for Research (PAVIR), Palo Alto Health Care System, Palo Alto, CA, USA.; Harvard Medical School, Boston, MA, USA., Challa S; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Rühle F; Bioinformatics Core Facility, Institute of Molecular Biology gGmbH (IMB), Mainz, Germany.; Department of Genetic Epidemiology, Institute of Human Genetics, University of Münster, Münster, Germany., Verdugo CD; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Krijger Juárez C; Department of Experimental Cardiology, Amsterdam Cardiovascular Sciences, Heart Failure & Arrhythmias, Amsterdam UMC location, University of Amsterdam, Amsterdam, the Netherlands., Kany S; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.; Department of Cardiology, University Heart and Vascular Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., van Orsouw CA; Department of Clinical Genetics, Amsterdam UMC location, University of Amsterdam, Amsterdam, the Netherlands., Biddinger K; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Poel E; Department of Experimental Cardiology, Amsterdam Cardiovascular Sciences, Heart Failure & Arrhythmias, Amsterdam UMC location, University of Amsterdam, Amsterdam, the Netherlands., Elliott AL; Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland.; Harvard Medical School, Boston, MA, USA.; Department of Psychiatry and Center for Genomic Medicine, Psychiatric and Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, USA., Wang X; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Francis C; National Heart and Lung Institute, Imperial College London, London, UK.; Royal Brompton and Harefield Hospitals, Guy's and St. Thomas' NHS Foundation Trust, London, UK., Ruan R; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Koyama S; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA., Beekman L; Department of Experimental Cardiology, Amsterdam Cardiovascular Sciences, Heart Failure & Arrhythmias, Amsterdam UMC location, University of Amsterdam, Amsterdam, the Netherlands., Zimmerman DS; Department of Experimental Cardiology, Amsterdam Cardiovascular Sciences, Heart Failure & Arrhythmias, Amsterdam UMC location, University of Amsterdam, Amsterdam, the Netherlands., Deleuze JF; CEA, Centre National de Recherche en Génomique Humaine, Université Paris-Saclay, Evry, France.; Laboratory of Excellence in Medical Genomics, GENMED, Evry, France.; Fondation Jean Dausset, Centre d'Etude du Polymorphisme Humain, Paris, France., Villard E; Research Unit on Cardiovascular Disorders, Metabolism and Nutrition, Team Genomics and Pathophysiology of Cardiovascular Disease, Sorbone Université, INSERM, Paris, France.; ICAN Institute for Cardiometabolism and Nutrition, Paris, France., Trégouët DA; Laboratory of Excellence in Medical Genomics, GENMED, Evry, France.; Bordeaux Population Health Research Center, UMR 1219, University of Bordeaux, INSERM, Bordeaux, France., Isnard R; Research Unit on Cardiovascular Disorders, Metabolism and Nutrition, Team Genomics and Pathophysiology of Cardiovascular Disease, Sorbone Université, INSERM, Paris, France.; ICAN Institute for Cardiometabolism and Nutrition, Paris, France.; APHP, Cardiology and Genetics Departments, Pitié-Salpêtrière Hospital, Paris, France., Boomsma DI; Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands., de Geus EJC; Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.; Amsterdam Public Health Research Institute, Amsterdam UMC location, Vrije Universiteit, Amsterdam, the Netherlands., Tadros R; Department of Experimental Cardiology, Amsterdam Cardiovascular Sciences, Heart Failure & Arrhythmias, Amsterdam UMC location, University of Amsterdam, Amsterdam, the Netherlands.; Cardiovascular Genetics Centre, Montreal Heart Institute, Montreal, QC, Canada.; Faculty of Medicine, Université de Montréal, Montreal, QC, Canada., Pinto YM; Department of Experimental Cardiology, Amsterdam Cardiovascular Sciences, Heart Failure & Arrhythmias, Amsterdam UMC location, University of Amsterdam, Amsterdam, the Netherlands.; European Reference Network for rare low prevalence and complex diseases of the heart: ERN GUARD-Heart, Amsterdam, the Netherlands.; Department of Clinical Cardiology, Amsterdam Cardiovascular Sciences, Heart Failure and Arrhythmias, Amsterdam UMC location, University of Amsterdam, Amsterdam, the Netherlands., Wilde AAM; Department of Experimental Cardiology, Amsterdam Cardiovascular Sciences, Heart Failure & Arrhythmias, Amsterdam UMC location, University of Amsterdam, Amsterdam, the Netherlands.; European Reference Network for rare low prevalence and complex diseases of the heart: ERN GUARD-Heart, Amsterdam, the Netherlands.; Department of Clinical Cardiology, Amsterdam Cardiovascular Sciences, Heart Failure and Arrhythmias, Amsterdam UMC location, University of Amsterdam, Amsterdam, the Netherlands., Hottenga JJ; Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.; The Netherlands Twin Register, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands., Sinisalo J; Department of Cardiology, Helsinki University Hospital, Helsinki, Finland.; Heart and Lung Center, Helsinki University Hospital and Helsinki University, Helsinki, Finland., Niiranen T; Department of Internal Medicine, University of Turku, Helsinki, Finland.; Division of Medicine, Turku University Hospital, Helsinki, Finland.; Finnish Institute for Health and Welfare (THL), Helsinki, Finland., Walsh R; Department of Experimental Cardiology, Amsterdam Cardiovascular Sciences, Heart Failure & Arrhythmias, Amsterdam UMC location, University of Amsterdam, Amsterdam, the Netherlands., Schmidt AF; Department of Clinical Cardiology, Amsterdam Cardiovascular Sciences, Heart Failure and Arrhythmias, Amsterdam UMC location, University of Amsterdam, Amsterdam, the Netherlands.; Institute of Cardiovascular Science, Faculty of Population Health, University College London, London, UK.; University College London British Heart Foundation Research Accelerator, London, UK.; Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Choi SH; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Biostatistics, Boston University, Boston, MA, USA., Chang KM; Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.; Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Tsao PS; Palo Alto Health Care System, Palo Alto, CA, USA.; Department of Medicine and Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA., Matthews PM; National Heart and Lung Institute, Imperial College London, London, UK.; MRC Laboratory of Medical Sciences, Imperial College London, London, UK., Ware JS; National Heart and Lung Institute, Imperial College London, London, UK.; MRC Laboratory of Medical Sciences, Imperial College London, London, UK.; Royal Brompton and Harefield Hospitals, Guy's and St. Thomas' NHS Foundation Trust, London, UK.; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA., Lumbers RT; Institute of Health Informatics, University College London, London, UK.; The National Institute for Health Research, University College London Hospitals Biomedical Research Centre, University College London, London, UK., van der Crabben S; Department of Clinical Genetics, Amsterdam UMC location, University of Amsterdam, Amsterdam, the Netherlands., Laukkanen J; Department of Medicine, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.; Central Finland Biobank, Central Finland Health Care District, Jyväskylä, Finland., Palotie A; Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland.; Program in Medical and Population Genetics and Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA., Amin AS; Department of Experimental Cardiology, Amsterdam Cardiovascular Sciences, Heart Failure & Arrhythmias, Amsterdam UMC location, University of Amsterdam, Amsterdam, the Netherlands.; European Reference Network for rare low prevalence and complex diseases of the heart: ERN GUARD-Heart, Amsterdam, the Netherlands.; Department of Clinical Cardiology, Amsterdam Cardiovascular Sciences, Heart Failure and Arrhythmias, Amsterdam UMC location, University of Amsterdam, Amsterdam, the Netherlands., Charron P; Research Unit on Cardiovascular Disorders, Metabolism and Nutrition, Team Genomics and Pathophysiology of Cardiovascular Disease, Sorbone Université, INSERM, Paris, France.; ICAN Institute for Cardiometabolism and Nutrition, Paris, France.; APHP, Cardiology and Genetics Departments, Pitié-Salpêtrière Hospital, Paris, France., Meder B; Department of Medicine III, Institute for Cardiomyopathies Heidelberg (ICH), University Hospital Heidelberg, Heidelberg, Germany.; Site Heidelberg/Mannheim, DZHK, Heidelberg, Germany., Ellinor PT; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA. ellinor@mgh.harvard.edu.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA. ellinor@mgh.harvard.edu., Daly M; Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland. mark.daly@helsinki.fi.; Program in Medical and Population Genetics and Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, USA. mark.daly@helsinki.fi.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA. mark.daly@helsinki.fi., Aragam KG; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA. karagam@broadinstitute.org.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA. karagam@broadinstitute.org., Bezzina CR; Department of Experimental Cardiology, Amsterdam Cardiovascular Sciences, Heart Failure & Arrhythmias, Amsterdam UMC location, University of Amsterdam, Amsterdam, the Netherlands. c.r.bezzina@amsterdamumc.nl.; European Reference Network for rare low prevalence and complex diseases of the heart: ERN GUARD-Heart, Amsterdam, the Netherlands. c.r.bezzina@amsterdamumc.nl.

Publikováno v: Nature genetics [Nat Genet] 2024 Dec; Vol. 56 (12), pp. 2843.

Whole-genome analysis of plasma fibrinogen reveals population-differentiated genetic regulators with putative liver roles.

Autor: Huffman JE; Palo Alto VA Institute for Research, VA Palo Alto Heath Care System, Palo Alto, CA.; MAVERIC, VA Boston Healthcare System, Boston, MA., Nicholas J; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC., Hahn J; Human Genetics Center, Department of Epidemiology, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX., Heath AS; Human Genetics Center, Department of Epidemiology, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX., Raffield LM; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC., Yanek LR; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD., Brody JA; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA., Thibord F; National Heart, Lung, and Blood Institute, Division of Intramural Research, Population Sciences Branch, The Framingham Heart Study, Framingham, MA., Almasy L; Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, PA., Bartz TM; Department of Biostatistics, University of Washington, Seattle, WA., Bielak LF; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI., Bowler RP; National Jewish Health, Denver, CO., Carrasquilla GD; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden., Chasman DI; Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA., Chen MH; National Heart, Lung, and Blood Institute, Division of Intramural Research, Population Sciences Branch, The Framingham Heart Study, Framingham, MA., Emmert DB; Institute for Biomedicine (affiliated to the University of Lübeck), Eurac Research, Bolzano, Italy., Ghanbari M; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands., Haessler J; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA., Hottenga JJ; Netherlands Twin Register, Department of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands., Kleber ME; SYNLAB MVZ für Humangenetik Mannheim, Mannheim, Germany.; Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Le NQ; Unit of Genomics of Complex Disease, Institut d'Investigació Biomèdica Sant Pau, Barcelona, Spain., Lee J; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA., Lewis JP; Department of Medicine, University of Maryland, Baltimore, MD., Li-Gao R; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands., Luan J; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom., Malmberg A; Department of Psychology and Logopedics, University of Helsinki, Helsinki, Finland., Mangino M; Department of Twin Research and Genetic Epidemiology, Kings College London, London, United Kingdom.; National Institute for Health and Care Research Biomedical Research Centre, Guy's and St Thomas' Foundation Trust, London, United Kingdom., Marioni RE; Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, Scotland, United Kingdom., Martinez-Perez A; Unit of Genomics of Complex Disease, Institut de Recerca Sant Paul, Barcelona, Spain.; Centre for Biomedical Network Research on Rare Diseases, Instituto de Salud Carlos III, Madrid, Spain., Pankratz N; Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN., Polasek O; Faculty of Medicine, University of Split, Split, Croatia., Richmond A; Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, Scotland, United Kingdom., Rodriguez BAT; National Heart, Lung, and Blood Institute, Division of Intramural Research, Population Sciences Branch, The Framingham Heart Study, Framingham, MA., Rotter JI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA., Steri M; Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Monserrato-Cagliari, Italy., Suchon P; Centre de Recherche en Cardiovascular et Nutrition, INSERM, Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement, Aix Marseille University, Marseille, France.; Laboratory of Haematology, La Timone Hospital, Marseille, France., Trompet S; Section of Gerontology and Geriatrics, Department of Internal Medicin, Leiden University Medical Center, Leiden, The Netherlands., Weiss S; Interfaculty Institute for Genetics and Functional Genomics, Department of Functional Genomics, German Center for Cardiovascular Research, Partner Site Greifswald, University Medicine Greifswald, Greifswald, Germany., Zare M; Maternal-Fetal Medicine Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom., Auer P; Division of Biostatistics, Institute for Health and Equity, and Cancer Center, Medical College of Wisconsin, Milwaukee, WI., Cho MH; Channing Division of Network Medicine and Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA., Christofidou P; Department of Twin Research and Genetic Epidemiology, Kings College London, London, United Kingdom., Davies G; Lothian Birth Cohorts, Department of Psychology, University of Edinburgh, Edinburgh, Scotland, United Kingdom., de Geus E; Netherlands Twin Register, Department of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands., Deleuze JF; Centre National de Recherche en Génomique Humaine, Commissariat a l'Energie Atomique et aux Energies Alternatives, Université Paris-Saclay, Evry, France., Delgado GE; Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Ekunwe L; Jackson Heart Study, University of Mississippi Medical Center, Jackson, MS., Faraday N; Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD., Gögele M; Institute for Biomedicine (affiliated to the University of Lübeck), Eurac Research, Bolzano, Italy., Greinacher A; Department of Transfusion Medicine, University Medicine Greifswald, Greifswald, Germany., Gao H; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom.; Medical Research Council-Public Health England Centre for Environment and Health, School of Public Health, Imperial College London, London, United Kingdom., Howard T; Department of Human Genetics, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX., Joshi PK; Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland., Kilpeläinen TO; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Lahti J; Department of Psychology and Logopedics, University of Helsinki, Helsinki, Finland., Linneberg A; Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark., Naitza S; Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Monserrato-Cagliari, Italy., Noordam R; Section of Gerontology and Geriatrics, Department of Internal Medicin, Leiden University Medical Center, Leiden, The Netherlands., Paüls-Vergés F; Unit of Genomics of Complex Disease, Institut d'Investigació Biomèdica Sant Pau, Barcelona, Spain., Rich SS; Department of Public Health Sciences, Center for Public Health Genomics, University of Virginia, Charlottesville, VA., Rosendaal FR; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands., Rudan I; Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland., Ryan KA; Department of Medicine, University of Maryland, Baltimore, MD., Souto JC; Unit of Genomics of Complex Disease, Institut de Recerca Sant Paul, Barcelona, Spain.; Centre for Biomedical Network Research on Rare Diseases, Instituto de Salud Carlos III, Madrid, Spain.; Unit of Thrombosis and Hemostasis, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain., van Rooij FJA; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands., Wang H; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA., Zhao W; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI.; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI., Becker LC; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD., Beswick A; Translational Health Sciences, University of Bristol, Bristol, United Kingdom., Brown MR; Human Genetics Center, Department of Epidemiology, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX., Cade BE; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA., Campbell H; Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland., Cho K; MAVERIC, VA Boston Healthcare System, Boston, MA.; Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, MA., Crapo JD; National Jewish Health, Denver, CO., Curran JE; Department of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX., de Maat MPM; Department of Hematology, Erasmus MC University Medical Center, Rotterdam, The Netherlands., Doyle M; Department of Pathology and Laboratory Medicine, The University of Vermont Larner College of Medicine, Colchester, VT., Elliott P; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom.; Medical Research Council-Public Health England Centre for Environment and Health, School of Public Health, Imperial College London, London, United Kingdom.; United Kingdom-Dementia Research Institute, Imperial College London, London, United Kingdom., Floyd JS; Departments of Medicine and Epidemiology, University of Washington, Seattle, WA., Fuchsberger C; Institute for Biomedicine (affiliated to the University of Lübeck), Eurac Research, Bolzano, Italy., Grarup N; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Guo X; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA., Harris SE; Lothian Birth Cohorts, Department of Psychology, University of Edinburgh, Edinburgh, Scotland, United Kingdom., Hou L; Department of Preventive Medicine, Northwestern University, Chicago, IL., Kolcic I; Faculty of Medicine, University of Split, Split, Croatia., Kooperberg C; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA., Menni C; Department of Twin Research and Genetic Epidemiology, Kings College London, London, United Kingdom., Nauck M; Institute of Clinical Chemistry and Laboratory Medicine, German Center for Cardiovascular Research, Partner Site Greifswald, Greifswald, Germany, University Medicine Greifswald, Greifswald, Germany., O'Connell JR; Department of Medicine, University of Maryland, Baltimore, MD., Orrù V; Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Lanusei, Italy., Psaty BM; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA.; Department of Epidemiology, University of Washington, Seattle, WA.; Department of Health Systems and Population Health, University of Washington, Seattle, WA., Räikkönen K; Department of Psychology and Logopedics, University of Helsinki, Helsinki, Finland., Smith JA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI.; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI., Soria JM; Unit of Genomics of Complex Disease, Institut de Recerca Sant Paul, Barcelona, Spain.; Centre for Biomedical Network Research on Rare Diseases, Instituto de Salud Carlos III, Madrid, Spain., Stott DJ; Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom., van Hylckama Vlieg A; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands., Watkins H; Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom., Willemsen G; Netherlands Twin Register, Department of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands., Wilson PWF; VA Atlanta Healthcare System, Decatur, GA.; Division of Cardiology, Emory University School of Medicine, Atlanta, GA.; Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA., Ben-Shlomo Y; Poulation Health Sciences, University of Bristol, Bristol, United Kingdom., Blangero J; Department of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX., Boomsma D; Netherlands Twin Register, Department of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands., Cox SR; Lothian Birth Cohorts, Department of Psychology, University of Edinburgh, Edinburgh, Scotland, United Kingdom., Dehghan A; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom.; Medical Research Council-Public Health England Centre for Environment and Health, School of Public Health, Imperial College London, London, United Kingdom.; United Kingdom-Dementia Research Institute, Imperial College London, London, United Kingdom., Eriksson JG; Department of General Practice and Primary Health Care, University of Helsinki, Helsinki, Finland.; Folkhälsan Research Centre, Helsinki, Finland.; Department of Obstetrics and Gynecology, Yong Loo Lin School of Medicine, National University Singapore, Singapore, Singapore., Fiorillo E; Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Lanusei, Italy., Fornage M; Brown Foundation Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX., Hansen T; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Hayward C; Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, Scotland, United Kingdom., Ikram MA; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands., Jukema JW; Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.; Netherlands Heart Institute, Utrecht, The Netherlands., Kardia SLR; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI., Lange LA; Division of Biomedical Informatics and Personalized Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO., März W; Synlab Academy, Synlab Holding Deutschland GmbH, and Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany., Mathias RA; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD., Mitchell BD; Department of Medicine, University of Maryland, Baltimore, MD.; Geriatric Research and Education Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore, MD., Mook-Kanamori DO; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.; Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands., Morange PE; Centre de Recherche en Cardiovascular et Nutrition, INSERM, Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement, Aix Marseille University, Marseille, France.; Laboratory of Haematology, La Timone Hospital, Marseille, France., Pedersen O; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Pramstaller PP; Institute for Biomedicine (affiliated to the University of Lübeck), Eurac Research, Bolzano, Italy., Redline S; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.; Department of Medicine, Beth Israel Deaconness Medical Center, Boston, MA., Reiner A; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA., Ridker PM; Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA., Silverman EK; Channing Division of Network Medicine and Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA., Spector TD; Department of Twin Research and Genetic Epidemiology, Kings College London, London, United Kingdom., Völker U; Interfaculty Institute for Genetics and Functional Genomics, Department of Functional Genomics, German Center for Cardiovascular Research, Partner Site Greifswald, University Medicine Greifswald, Greifswald, Germany., Wareham NJ; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom., Wilson JF; Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, Scotland, United Kingdom.; Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland., Yao J; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA., Trégouët DA; Bordeaux Population Health Research Center, INSERM UMR 1219, University of Bordeaux, Bordeaux, France., Johnson AD; National Heart, Lung, and Blood Institute, Division of Intramural Research, Population Sciences Branch, The Framingham Heart Study, Framingham, MA., Wolberg AS; Department of Pathology and Laboratory Medicine and UNC Blood Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC., de Vries PS; Human Genetics Center, Department of Epidemiology, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX., Sabater-Lleal M; Unit of Genomics of Complex Disease, Institut de Recerca Sant Paul, Barcelona, Spain.; Centre for Biomedical Network Research on Rare Diseases, Instituto de Salud Carlos III, Madrid, Spain.; Cardiovascular Medicine Unit, Department of Medicine, Karolinska Institutet, Center for Molecular Medicine, Stockholm, Sweden., Morrison AC; Human Genetics Center, Department of Epidemiology, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX., Smith NL; Department of Epidemiology, University of Washington, Seattle, WA.; Kaiser Permanente Washington Health Research Institute, Kaiser Permanente Washington, Seattle, WA.; Seattle Epidemiologic Research and Information Center, Department of Veterans Affairs Office of Research and Development, Seattle, WA.

Publikováno v: Blood [Blood] 2024 Nov 21; Vol. 144 (21), pp. 2248-2265.