INFORMAL DISCUSSION. COMPUTER AIDED BRIDGE DESIGN

Autor: Rm Walsham, Je Golden, S Shanmugam, Am Low

Publikováno v: Proceedings of the Institution of Civil Engineers. 80:1153-1158

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3f08f9aef915ae517fb9d508df0737d4
https://doi.org/10.1680/iicep.1986.645

Pharmacophore Establishment and Optimization of Saturated 1,6-Naphthyridine-Fused Quinazolinones that Inhibit Meningoencephalitis-Causing Naegleria fowleri .

Autor: Lish MS; Department of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States., McKeon JEM; Eukaryotic Pathogens Innovation Center, Department of Genetics and Biochemistry, Clemson University, Clemson, South Carolina 29634, United States., Palmentiero CM; Eukaryotic Pathogens Innovation Center, Department of Genetics and Biochemistry, Clemson University, Clemson, South Carolina 29634, United States., Pomeroy JM; Department of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States., Roster CP; Eukaryotic Pathogens Innovation Center, Department of Genetics and Biochemistry, Clemson University, Clemson, South Carolina 29634, United States., Guzei IA; Molecular Structure Laboratory, Department of Chemistry, University of Wisconsin-Madison, 1101 University Avenue, Madison, Wisconsin 53706, United States., Morris JC; Eukaryotic Pathogens Innovation Center, Department of Genetics and Biochemistry, Clemson University, Clemson, South Carolina 29634, United States., Golden JE; Department of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States.; School of Pharmacy, Division of Pharmaceutical Sciences, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2024 Oct 24; Vol. 67 (20), pp. 18265-18289. Date of Electronic Publication: 2024 Oct 15.

Mannich-Type Condensation and Domino Quinazolinone-Amidine Rearrangement Affords Ring-Fused Mackinazolinones with Anti-Amoebic Activity.

Autor: Lish MS; Department of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin, 53706, United States., Milanes JE; Eukaryotic Pathogens Innovation Center, Department of Genetics and Biochemistry, Clemson University, Clemson, South Carolina, 29634, United States., Sanders KM; Department of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin, 53706, United States.; Molecular Structure Laboratory, Department of Chemistry, University of Wisconsin-Madison, 1101 University Avenue, Madison, Wisconsin 53706, United States., Guzei IA; Molecular Structure Laboratory, Department of Chemistry, University of Wisconsin-Madison, 1101 University Avenue, Madison, Wisconsin 53706, United States., Morris JC; Eukaryotic Pathogens Innovation Center, Department of Genetics and Biochemistry, Clemson University, Clemson, South Carolina, 29634, United States., Golden JE; Department of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin, 53706, United States.; School of Pharmacy, Division of Pharmaceutical Sciences, University of Wisconsin-Madison, Madison, WI, 53705, United States.

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Efficacy of a brain-penetrant antiviral in lethal Venezuelan and eastern equine encephalitis mouse models.

Autor: Cao X; School of Pharmacy, Pharmaceutical Sciences Division, University of Wisconsin-Madison, Madison, WI 53705, USA., Yang D; Regional Biocontainment Laboratory, University of Tennessee Health Science Center, Memphis, TN 38163, USA., Parvathareddy J; Regional Biocontainment Laboratory, University of Tennessee Health Science Center, Memphis, TN 38163, USA., Chu YK; Center for Predictive Medicine, Department of Microbiology Immunology, School of Medicine, University of Louisville, Louisville, KY 40202, USA., Kim EJ; Center for Predictive Medicine, Department of Microbiology Immunology, School of Medicine, University of Louisville, Louisville, KY 40202, USA., Fitz-Henley JN; School of Pharmacy, Pharmaceutical Sciences Division, University of Wisconsin-Madison, Madison, WI 53705, USA., Li X; School of Pharmacy, Pharmaceutical Sciences Division, University of Wisconsin-Madison, Madison, WI 53705, USA., Lukka PB; Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN 38163, USA., Parmar KR; Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN 38163, USA., Temrikar ZH; Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN 38163, USA., Dhole P; Center for Predictive Medicine, Department of Microbiology Immunology, School of Medicine, University of Louisville, Louisville, KY 40202, USA., Adcock RS; Center for Predictive Medicine, Department of Microbiology Immunology, School of Medicine, University of Louisville, Louisville, KY 40202, USA., Gabbard J; Center for Predictive Medicine, Department of Microbiology Immunology, School of Medicine, University of Louisville, Louisville, KY 40202, USA., Bansal S; Regional Biocontainment Laboratory, University of Tennessee Health Science Center, Memphis, TN 38163, USA., Lee J; Departments of Microbiology, Immunology, Biochemistry, University of Tennessee Health Science Center, Memphis, TN 38163, USA., Zalduondo L; Regional Biocontainment Laboratory, University of Tennessee Health Science Center, Memphis, TN 38163, USA., Hayes E; Regional Biocontainment Laboratory, University of Tennessee Health Science Center, Memphis, TN 38163, USA., Stabenow J; Regional Biocontainment Laboratory, University of Tennessee Health Science Center, Memphis, TN 38163, USA., Meibohm B; Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN 38163, USA., Fitzpatrick EA; Regional Biocontainment Laboratory, University of Tennessee Health Science Center, Memphis, TN 38163, USA.; Departments of Microbiology, Immunology, Biochemistry, University of Tennessee Health Science Center, Memphis, TN 38163, USA., Bailey K; Institute for Antiviral Research, Utah State University, Logan, UT 84322, USA., Campos RK; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA., Julander JG; Institute for Antiviral Research, Utah State University, Logan, UT 84322, USA., Rossi SL; Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA., Chung D; Center for Predictive Medicine, Department of Microbiology Immunology, School of Medicine, University of Louisville, Louisville, KY 40202, USA., Jonsson CB; Regional Biocontainment Laboratory, University of Tennessee Health Science Center, Memphis, TN 38163, USA.; Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN 38163, USA.; Departments of Microbiology, Immunology, Biochemistry, University of Tennessee Health Science Center, Memphis, TN 38163, USA., Golden JE; School of Pharmacy, Pharmaceutical Sciences Division, University of Wisconsin-Madison, Madison, WI 53705, USA.; Department of Chemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.

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Dihydropyrazinoquinazolinones via S N 2 Sulfamidate Ring-Opening and a Sequential Quinazolinone-Amidine Rearrangement Strategy (SQuAReS).

Autor: Fitz-Henley JN; Division of Pharmaceutical Sciences, School of Pharmacy, University of Wisconsin─Madison, 777 Highland Avenue, Madison, Wisconsin 53705, United States., Rozema SD; Division of Pharmaceutical Sciences, School of Pharmacy, University of Wisconsin─Madison, 777 Highland Avenue, Madison, Wisconsin 53705, United States., Golden JE; Division of Pharmaceutical Sciences, School of Pharmacy, University of Wisconsin─Madison, 777 Highland Avenue, Madison, Wisconsin 53705, United States.

Publikováno v: The Journal of organic chemistry [J Org Chem] 2022 Nov 04; Vol. 87 (21), pp. 14889-14898. Date of Electronic Publication: 2022 Oct 04.