N-Formylcarbamoylaspartame, a new aspartame-like sweetener. Synthesis and studies on stability and biological properties

Autor: Whj Boesten, van der Sj Wal, de Nk Koen Vries, Bhn Dassen, Emmo M. Meijer, Hans E. Schoemaker, van B Agen, Jcs Kleinjans

Publikováno v: Journal of Agricultural and Food Chemistry, 39(1), 154-158. American Chemical Society

A new aspartam-like sweetener (FC-APM) was prepared from aspartame (APM). Due to the protective group, FC-APM is less prone to diketopiperazine formation and therefore much more stable than aspartame at higher pH values and temperatures. A relatively

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5add3c08fa55e4d343555756ded6a9c4
https://research.tue.nl/nl/publications/25d05aeb-13c7-4273-a428-45f51127baa3

Transcriptomic Analysis in Human 3D Skin Model Injected with Resorbable Hyaluronic Acid Fillers Reveals Foreign Body Response.

Autor: Jennen DGJ; Department of Toxicogenomics, GROW School for Oncology and Reproduction, Maastricht University, 6200 Maastricht, The Netherlands., van Herwijnen M; Department of Toxicogenomics, GROW School for Oncology and Reproduction, Maastricht University, 6200 Maastricht, The Netherlands., Jetten M; Department of Toxicogenomics, GROW School for Oncology and Reproduction, Maastricht University, 6200 Maastricht, The Netherlands., Vandebriel RJ; Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), 3720 Bilthoven, The Netherlands., Keizers P; Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), 3720 Bilthoven, The Netherlands., Geertsma RE; Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), 3720 Bilthoven, The Netherlands., de Jong WH; Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), 3720 Bilthoven, The Netherlands., Kleinjans JCS; Department of Toxicogenomics, GROW School for Oncology and Reproduction, Maastricht University, 6200 Maastricht, The Netherlands.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2022 Oct 27; Vol. 23 (21). Date of Electronic Publication: 2022 Oct 27.

Correction to: Toxicogenomics directory of chemically exposed human hepatocytes.

Autor: Grinberg M; Department of Statistics, TU Dortmund University, Dortmund, Germany., Stöber RM; Leibniz Research Centre for Working Environment and Human Factors at the Technical University of Dortmund (IfADo), Ardeystrasse 67, 44139, Dortmund, Germany., Edlund K; Leibniz Research Centre for Working Environment and Human Factors at the Technical University of Dortmund (IfADo), Ardeystrasse 67, 44139, Dortmund, Germany., Rempel E; Department of Statistics, TU Dortmund University, Dortmund, Germany., Godoy P; Leibniz Research Centre for Working Environment and Human Factors at the Technical University of Dortmund (IfADo), Ardeystrasse 67, 44139, Dortmund, Germany., Reif R; Leibniz Research Centre for Working Environment and Human Factors at the Technical University of Dortmund (IfADo), Ardeystrasse 67, 44139, Dortmund, Germany., Widera A; Leibniz Research Centre for Working Environment and Human Factors at the Technical University of Dortmund (IfADo), Ardeystrasse 67, 44139, Dortmund, Germany., Madjar K; Department of Statistics, TU Dortmund University, Dortmund, Germany., Schmidt-Heck W; Leibniz Institute for Natural Product Research and Infection Biology, Hans Knoell Institute, Jena, Germany., Marchan R; Leibniz Research Centre for Working Environment and Human Factors at the Technical University of Dortmund (IfADo), Ardeystrasse 67, 44139, Dortmund, Germany., Sachinidis A; Center of Physiology and Pathophysiology, Institute of Neurophysiology, University of Cologne (UKK), Cologne, Germany., Spitkovsky D; Center of Physiology and Pathophysiology, Institute of Neurophysiology, University of Cologne (UKK), Cologne, Germany., Hescheler J; Center of Physiology and Pathophysiology, Institute of Neurophysiology, University of Cologne (UKK), Cologne, Germany., Carmo H; Laboratório de Toxicologia, Departamento de Ciências Biológicas, Universidade do Porto, Porto, Portugal., Arbo MD; Laboratório de Toxicologia, Departamento de Ciências Biológicas, Universidade do Porto, Porto, Portugal., van de Water B; Division of Toxicology, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands., Wink S; Division of Toxicology, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands., Vinken M; Department of Toxicology, Dermato-Cosmetology and Pharmacognosy (FAFY), Center for Pharmaceutical Research (CePhaR), Vrije Universiteit Brussel (VUB), Brussels, Belgium., Rogiers V; Department of Toxicology, Dermato-Cosmetology and Pharmacognosy (FAFY), Center for Pharmaceutical Research (CePhaR), Vrije Universiteit Brussel (VUB), Brussels, Belgium., Escher S; Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM), Hannover, Germany., Hardy B; Douglas Connect and OpenTox, Zeiningen, Switzerland., Mitic D; Cambridge Cell Networks, Cambridge, UK., Apic G; Cell Networks GmbH, Lutherstr. 59, 69120, Heidelberg, Germany., Myatt G; Leadscope, Columbus, OH, USA., Waldmann T; Department of Biology, University of Konstanz, Konstanz, Germany., Mardinoglu A; Department of Chemical and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden., Damm G; Department of General-, Visceral- and Transplantation Surgery, Charité University Medicine Berlin, Berlin, Germany., Seehofer D; Department of General-, Visceral- and Transplantation Surgery, Charité University Medicine Berlin, Berlin, Germany., Nüssler A; Department of Traumatology, Eberhard Karls Universität Tübingen, Tübingen, Germany., Weiss TS; Department of Pediatrics and Juvenile Medicine, University of Regensburg Hospital, Regensburg, Germany., Oberemm A; Federal Institute for Risk Assessment, Berlin, Germany., Lampen A; Federal Institute for Risk Assessment, Berlin, Germany., Schaap MM; Center for Health Protection, National Institute for Public Health and the Environment, Bilthoven, The Netherlands., Luijten M; Center for Health Protection, National Institute for Public Health and the Environment, Bilthoven, The Netherlands., van Steeg H; Center for Health Protection, National Institute for Public Health and the Environment, Bilthoven, The Netherlands., Thasler WE; Department of Surgery, Grosshadern Hospital, Munich, Germany., Kleinjans JCS; Department of Health Risk Analysis and Toxicology, Maastricht University, Maastricht, The Netherlands., Stierum RH; TNO Quality of Life, Zeist, The Netherlands., Leist M; Department of Biology, University of Konstanz, Konstanz, Germany., Rahnenführer J; Department of Statistics, TU Dortmund University, Dortmund, Germany., Hengstler JG; Leibniz Research Centre for Working Environment and Human Factors at the Technical University of Dortmund (IfADo), Ardeystrasse 67, 44139, Dortmund, Germany. hengstler@ifado.de.

Publikováno v: Archives of toxicology [Arch Toxicol] 2022 Mar; Vol. 96 (3), pp. 945-946.

Unravelling Mechanisms of Doxorubicin-Induced Toxicity in 3D Human Intestinal Organoids.

Autor: Rodrigues D; Department of Toxicogenomics, GROW School for Oncology and Developmental Biology, Maastricht University, 6229 ER Maastricht, The Netherlands., Coyle L; Boehringer Ingelheim International GmbH, Pharmaceuticals Inc., Ridgefield, CT 06877, USA., Füzi B; Department of Pharmaceutical Sciences, University of Vienna, Althanstrasse 14, 1090 Vienna, Austria., Ferreira S; Certara UK Limited, Simcyp Division, Sheffield S1 2BJ, UK., Jo H; Certara UK Limited, Simcyp Division, Sheffield S1 2BJ, UK., Herpers B; Crown Bioscience Netherlands B.V., J.H. Oortweg 21, 2333 CH Leiden, The Netherlands., Chung SW; Boehringer Ingelheim International GmbH, Pharmaceuticals Inc., Ridgefield, CT 06877, USA., Fisher C; Certara UK Limited, Simcyp Division, Sheffield S1 2BJ, UK., Kleinjans JCS; Department of Toxicogenomics, GROW School for Oncology and Developmental Biology, Maastricht University, 6229 ER Maastricht, The Netherlands., Jennen D; Department of Toxicogenomics, GROW School for Oncology and Developmental Biology, Maastricht University, 6229 ER Maastricht, The Netherlands., de Kok TM; Department of Toxicogenomics, GROW School for Oncology and Developmental Biology, Maastricht University, 6229 ER Maastricht, The Netherlands.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2022 Jan 24; Vol. 23 (3). Date of Electronic Publication: 2022 Jan 24.

New insights into the mechanisms underlying 5-fluorouracil-induced intestinal toxicity based on transcriptomic and metabolomic responses in human intestinal organoids.

Autor: Rodrigues D; Department of Toxicogenomics, GROW School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands. d.rodrigues@maastrichtuniversity.nl., de Souza T; Department of Toxicogenomics, GROW School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands., Coyle L; Departmnet of Nonclinical Drug Safety, Boehringer Ingelheim Pharmaceuticals Inc, Ridgefield, CT, USA., Di Piazza M; Departmnet of Nonclinical Drug Safety, Boehringer Ingelheim Pharmaceuticals Inc, Ridgefield, CT, USA.; F. Hoffmann-La Roche AG, Basel, Switzerland., Herpers B; OcellO B.V., BioPartner Center, Leiden, the Netherlands., Ferreira S; Certara UK Limited, Simcyp Division, Sheffield, S1 2BJ, UK., Zhang M; Certara UK Limited, Simcyp Division, Sheffield, S1 2BJ, UK., Vappiani J; GSK Functional Genomics/Cellzome, 69117, Heidelberg, Germany., Sévin DC; GSK Functional Genomics/Cellzome, 69117, Heidelberg, Germany., Gabor A; Faculty of Medicine, Heidelberg University Hospital, Institute for Computational Biomedicine, Heidelberg, Germany., Lynch A; GSK Non-Clinical Safety, Ware, SG12 0DP, UK., Chung SW; Departmnet of Nonclinical Drug Safety, Boehringer Ingelheim Pharmaceuticals Inc, Ridgefield, CT, USA., Saez-Rodriguez J; GSK Non-Clinical Safety, Ware, SG12 0DP, UK.; Faculty of Medicine, Joint Research Centre for Computational Biomedicine (JRC-COMBINE), RWTH Aachen University, Aachen, Germany.; Molecular Medicine Partnership Unit, European Molecular Biology Laboratory, Heidelberg University, Heidelberg, Germany., Jennen DGJ; Department of Toxicogenomics, GROW School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands., Kleinjans JCS; Department of Toxicogenomics, GROW School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands., de Kok TM; Department of Toxicogenomics, GROW School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands.

Publikováno v: Archives of toxicology [Arch Toxicol] 2021 Aug; Vol. 95 (8), pp. 2691-2718. Date of Electronic Publication: 2021 Jun 20.