Abstract ES6-1: How tumor metabolism contributes to the immunosuppressive microenvironment

Autor: JC Rathmell

Publikováno v: Cancer Research. 78:ES6-1

Lymphocyte activation leads to rapid proliferation and differentiation and we have shown that T cell subsets require distinct metabolic programs. The effector CD4 T cell fates (Th1, Th2, Th17) activate a highly glycolytic program. Regulatory CD4 T ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::771816e3880006bd3d6f46b820043897
https://doi.org/10.1158/1538-7445.sabcs17-es6-1

Temporal recording of mammalian development and precancer.

Autor: Islam M; Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA., Yang Y; Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA., Simmons AJ; Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA., Shah VM; Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA., Musale KP; Department of Computer Science and Engineering, Indian Institute of Technology Kanpur, Kanpur, India., Xu Y; Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA., Tasneem N; Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA., Chen Z; Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, TN, USA.; Chemical and Physical Biology Program, Vanderbilt University, Nashville, TN, USA., Trinh LT; Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA.; Vanderbilt Center for Stem Cell Biology, Vanderbilt University, Nashville, TN, USA., Molina P; Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA., Ramirez-Solano MA; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA.; Center for Quantitative Sciences, Vanderbilt University Medical Center, Nashville, TN, USA., Sadien ID; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK., Dou J; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Rolong A; Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA., Chen K; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Magnuson MA; Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA.; Vanderbilt Center for Stem Cell Biology, Vanderbilt University, Nashville, TN, USA.; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA., Rathmell JC; Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA., Macara IG; Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA., Winton DJ; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK., Liu Q; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA.; Center for Quantitative Sciences, Vanderbilt University Medical Center, Nashville, TN, USA., Zafar H; Department of Computer Science and Engineering, Indian Institute of Technology Kanpur, Kanpur, India.; Department of Biological Sciences and Bioengineering, Indian Institute of Technology Kanpur, Kanpur, India., Kalhor R; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Church GM; Department of Genetics, Harvard Medical School, Boston, MA, USA.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA., Shrubsole MJ; Department of Medicine, Division of Epidemiology, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA., Coffey RJ; Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, TN, USA. robert.coffey@vumc.org.; Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA. robert.coffey@vumc.org.; Vanderbilt Center for Stem Cell Biology, Vanderbilt University, Nashville, TN, USA. robert.coffey@vumc.org.; Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA. robert.coffey@vumc.org.; Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, Vanderbilt University Medical Center, Nashville, TN, USA. robert.coffey@vumc.org., Lau KS; Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, TN, USA. ken.s.lau@vanderbilt.edu.; Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA. ken.s.lau@vanderbilt.edu.; Chemical and Physical Biology Program, Vanderbilt University, Nashville, TN, USA. ken.s.lau@vanderbilt.edu.; Vanderbilt Center for Stem Cell Biology, Vanderbilt University, Nashville, TN, USA. ken.s.lau@vanderbilt.edu.; Center for Quantitative Sciences, Vanderbilt University Medical Center, Nashville, TN, USA. ken.s.lau@vanderbilt.edu.; Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, TN, USA. ken.s.lau@vanderbilt.edu.; Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA. ken.s.lau@vanderbilt.edu.; Department of Surgery, Vanderbilt University Medical Center, Nashville, TN, USA. ken.s.lau@vanderbilt.edu.

Publikováno v: Nature [Nature] 2024 Oct; Vol. 634 (8036), pp. 1187-1195. Date of Electronic Publication: 2024 Oct 30.

Trem2 deficiency attenuates breast cancer tumor growth in lean, but not obese or weight loss, mice and is associated with alterations of clonal T cell populations.

Autor: Pierro EW; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN., Cottam MA; Department of Surgery, Division of Surgical Oncology and Endocrine Surgery, Vanderbilt University Medical Center, Nashville, TN., An H; Department of Otolaryngology, Vanderbilt University Medical Center, Nashville, TN., Lehmann BD; Department of Medicine, Division of Hematology and Oncology, Vanderbilt University Medical Center, Nashville, TN.; Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN., Pietenpol JA; Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN.; Department of Biochemistry, Vanderbilt University, Nashville, TN., Wellen KE; Department of Cancer Biology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA., Makowski L; Department of Medicine, Division of Hematology-Oncology, University of Tennessee Health Science Center, Memphis, TN, 31863, USA., Rathmell JC; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN.; Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN.; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN.; Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, TN., Fingleton B; Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN.; Department of Pharmacology, Vanderbilt University, Nashville, TN., Hasty AH; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN.; Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN.; Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, TN.; Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN.; Department of Internal Medicine, Touchstone Diabetes Center, UT Southwestern, Dallas, TX.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Sep 27. Date of Electronic Publication: 2024 Sep 27.

Immunometabolic Maladaptations to the Tumor Microenvironment.

Autor: Hathaway ES; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA., Jennings EQ; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA., Rathmell JC; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA jeff.rathmell@vumc.org.; Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA.

Publikováno v: Cold Spring Harbor perspectives in medicine [Cold Spring Harb Perspect Med] 2024 Sep 03; Vol. 14 (9). Date of Electronic Publication: 2024 Sep 03.

Functional overlap of inborn errors of immunity and metabolism genes defines T cell metabolic vulnerabilities.

Autor: Patterson AR; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA., Needle GA; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA., Sugiura A; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA., Jennings EQ; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA., Chi C; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA., Steiner KK; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA., Fisher EL; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA., Robertson GL; Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA., Bodnya C; Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA., Markle JG; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, TN, USA., Sheldon RD; Mass Spectrometry Core, Core Technologies and Services, Van Andel Institute, Grand Rapids, MI, USA., Jones RG; Department of Metabolism and Nutritional Programming, Van Andel Research Institute, Grand Rapids, MI, USA., Gama V; Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA., Rathmell JC; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, TN, USA.

Publikováno v: Science immunology [Sci Immunol] 2024 Aug 16; Vol. 9 (98), pp. eadh0368. Date of Electronic Publication: 2024 Aug 16.