Zobrazeno 1 - 10
of 1 773
pro vyhledávání: '"Jc, Lin"'
Autor:
Wei Liu, Mohamad-Gabriel Alameh, June F. Yang, Jonathan R. Xu, Paulo JC Lin, Ying K Tam, Drew Weissman, Jianxin You
Treating immunosuppressive tumors represents a major challenge in cancer therapies. Activation of STING signaling has shown remarkable potential to invigorate the immunologically ‘cold’ tumor microenvironment (TME). However, we and others have sh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d509e8c2da2cc943fb23b7e4220ba60
https://doi.org/10.1101/2022.01.08.475499
https://doi.org/10.1101/2022.01.08.475499
Autor:
Justin B Lee, Kaixin Zhang, Yuen Yi C Tam, Joslyn Quick, Ying K Tam, Paulo JC Lin, Sam Chen, Yan Liu, Jayaprakash K Nair, Ivan Zlatev, Kallanthottathil G Rajeev, Muthiah Manoharan, Paul S Rennie, Pieter R Cullis
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 5, Iss C (2016)
The androgen receptor plays a critical role in the progression of prostate cancer. Here, we describe targeting the prostate-specific membrane antigen using a lipid nanoparticle formulation containing small interfering RNA designed to silence expressi
Externí odkaz:
https://doaj.org/article/6f4fc54f8a004c18b091a7dfbda75b0a
Autor:
Barbara L Mui, Ying K Tam, Muthusamy Jayaraman, Steven M Ansell, Xinyao Du, Yuen Yi C Tam, Paulo JC Lin, Sam Chen, Jayaprakash K Narayanannair, Kallanthottathil G Rajeev, Muthiah Manoharan, Akin Akinc, Martin A Maier, Pieter Cullis, Thomas D Madden, Michael J Hope
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 2, Iss C (2013)
Lipid nanoparticles (LNPs) encapsulating short interfering RNAs that target hepatic genes are advancing through clinical trials, and early results indicate the excellent gene silencing observed in rodents and nonhuman primates also translates to huma
Externí odkaz:
https://doaj.org/article/f5677ebf4c334dbe9c9d38a4979393bb
Microfluidic Synthesis of Highly Potent Limit-size Lipid Nanoparticles for In Vivo Delivery of siRNA
Autor:
Nathan M Belliveau, Jens Huft, Paulo JC Lin, Sam Chen, Alex KK Leung, Timothy J Leaver, Andre W Wild, Justin B Lee, Robert J Taylor, Ying K Tam, Carl L Hansen, Pieter R Cullis
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 1, Iss C (2012)
Lipid nanoparticles (LNP) are the leading systems for in vivo delivery of small interfering RNA (siRNA) for therapeutic applications. Formulation of LNP siRNA systems requires rapid mixing of solutions containing cationic lipid with solutions contain
Externí odkaz:
https://doaj.org/article/0c307fb90bf9468baca62b6496dabe0e
Autor:
Eliana Beraldi, Hidemasa Katsumi, Fan Zhang, Martin E. Gleave, Ladan Fazli, Pieter R. Cullis, Yoshihisa Kawai, Paulo Jc Lin, Yoshiaki Yamamoto, Jeffrey W. Leong, Robert Fraser
Publikováno v:
Clinical Cancer Research. 21:4845-4855
Purpose: Lipid nanoparticle (LNP) formulations facilitate tumor uptake and intracellular processing through an enhanced permeation and retention effect (EPR), and currently multiple products are undergoing clinical evaluation. Clusterin (CLU) is a cy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff07356f0369dea33f59ccffe373d674
https://doi.org/10.1158/1078-0432.ccr-15-0866
https://doi.org/10.1158/1078-0432.ccr-15-0866
Publikováno v:
Indian Journal of Medical Microbiology, Vol 33, Iss 4, Pp 516-523 (2015)
Purpose: To establish a new genotyping method for Vibrio cholerae and compare it with other methods. Materials and Methods: In the current study, a modified inter simple sequence repeat-polymerase chain reaction (MISSR-PCR) system was developed via s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7d2edc5de49e1c808783ca26393cbc8
http://www.ijmm.org/article.asp?issn=0255-0857
http://www.ijmm.org/article.asp?issn=0255-0857
Publikováno v:
Clinical Lipidology. 9:317-331
Efficient delivery of siRNA to cancer cells after systemic administration poses a significant challenge. While many methods of nucleic acid delivery have been described, encapsulation of siRNA in lipid nanoparticles (LNPs) represents the most clinica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a3902b7456b1db9ed2cd71489a86f294
https://doi.org/10.2217/clp.14.27
https://doi.org/10.2217/clp.14.27
Autor:
Kallanthottathil G. Rajeev, Paul S. Rennie, Ivan Zlatev, Kaixin Zhang, Ying K. Tam, Yuen Yi C. Tam, Paulo Jc Lin, Justin B. Lee, Yan Liu, Sam Chen, Pieter R. Cullis, Muthiah Manoharan, Jayaprakash K. Nair, Joslyn Quick
Publikováno v:
Molecular Therapy. Nucleic Acids
Molecular Therapy: Nucleic Acids, Vol 5, Iss C (2016)
Molecular Therapy: Nucleic Acids, Vol 5, Iss C (2016)
The androgen receptor plays a critical role in the progression of prostate cancer. Here, we describe targeting the prostate-specific membrane antigen using a lipid nanoparticle formulation containing small interfering RNA designed to silence expressi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88a79f12b9fcd0999a667aa7d682ea76
Autor:
RF Swaby, Atc Chan, C Gause, QS Ng, JC Lin, Vhf Lee, R. Ngan, Myung-Ju Ahn, Anna Spreafico, S Saraf, Ka Fai To, R.-L. Hong
Publikováno v:
Annals of Oncology. 27:ix122
This journal suppl. entitled: Abstract Book of ESMO Asia Congress Singapore, 16–19 December 2016
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::72026dfbc0d45cf6a878235d373a0426
https://doi.org/10.1016/s0923-7534(21)00552-4
https://doi.org/10.1016/s0923-7534(21)00552-4
Publikováno v:
Blood. 81:3372-3381
To precisely determine the genotype of Epstein-Barr virus (EBV) in Hodgkin's disease (HD), we simultaneously analyzed three divergent gene loci (EBNA-2, EBNA-3C, and EBER) that distinguish type A and B viruses. The primers designed to amplify these t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49782247beeb79b8d08f60edc088bb9a
https://doi.org/10.1182/blood.v81.12.3372.3372
https://doi.org/10.1182/blood.v81.12.3372.3372