Zobrazeno 1 - 10
of 284
pro vyhledávání: '"Jazwinski Sm"'
Autor:
Jazwinski Sm
Publikováno v:
Mechanisms of Ageing and Development. 122:865-882
The yeast Saccharomyces cerevisiae has been used as an experimental model for the genetic and molecular dissecton of the aging process for the past decade. This period has seen the implication of some 30 genes in yeast aging. These genes encode a wid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dab3e4f989d9ef08121c6c1e94f9ec76
https://doi.org/10.1016/s0047-6374(01)00244-5
https://doi.org/10.1016/s0047-6374(01)00244-5
Autor:
Jazwinski Sm
Publikováno v:
Trends in Microbiology. 7:247-252
The genetic analysis of yeast longevity has illuminated the underlying molecular mechanisms of aging that invoke the importance of metabolic regulation, genetic stability and stress resistance in determination of life span. The RAS genes have emerged
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::092e6480f63129274db0e1c57dc1ce37
https://doi.org/10.1016/s0966-842x(99)01509-7
https://doi.org/10.1016/s0966-842x(99)01509-7
Publikováno v:
Genome Research. 8:1259-1272
LAG1 is a longevity gene, the first such gene to be identified and cloned from the yeast Saccharomyces cerevisiae. A close homolog of this gene, which we call LAC1, has been found in the yeast genome. We have cloned the human homolog ofLAG1 with the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18e215f41ec5a515584b9881251dce56
https://doi.org/10.1101/gr.8.12.1259
https://doi.org/10.1101/gr.8.12.1259
Publikováno v:
Biochemical and Biophysical Research Communications. 219:370-376
Individual yeasts have a finite replicative life span in similarity to normal human fibroblasts. Telomere loss is a hallmark of replicative senescence in normal human fibroblasts and has been proposed to play a role in cellular senescence, perhaps by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb0b3c4b6d5feec17e756409e7e3bd64
https://doi.org/10.1006/bbrc.1996.0240
https://doi.org/10.1006/bbrc.1996.0240
Publikováno v:
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. :B1-B8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::37fd1298e33dbc71ba47b991c2704f30
https://doi.org/10.1093/gerona/50a.1.b1
https://doi.org/10.1093/gerona/50a.1.b1
Autor:
Jazwinski Sm
Publikováno v:
Genetica. 91:35-51
The yeast Saccharomyces cerevisiae possesses a finite life span similar in many attributes and implications to that of higher eukaryotes. Here, the measure of the life span is the number of generations or divisions the yeast cell has undergone. The y
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68383396da264b6231adef510462a385
https://doi.org/10.1007/bf01435986
https://doi.org/10.1007/bf01435986
Autor:
Jazwinski, Sm, Kim, S., Dai, J., Li, L., Bi, X., Jiang, Jc, Arnold, J., Batzer, Ma, Walker, Ja, Welsh, Da, Lefante, Cm, Volaufova, J., Myers, L., Lj, Su, Hausman, Db, Miceli, Mv, Ravussin, E., Poon, Lw, Cherry, Ke, Welsch, Ma, Georgia Centenarian Study, Ermolao, Andrea
The search for longevity-determining genes in human has largely neglected the operation of genetic interactions. We have identified a novel combination of common variants of three genes that has a marked association with human lifespan and healthy ag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::aca3619ae6a76d13bd172ef9252edfca
http://hdl.handle.net/11577/2488272
http://hdl.handle.net/11577/2488272
Autor:
Frisard, Im, Rood, Jc, Fang, X., Su, J., Welsh, Da, Jazwinski, Sm, Ravussin, E., Ermolao, Andrea
Publikováno v:
Age
This study assessed cardiovascular disease risk factors in three groups of human subjects aged 20–34 [young, 20 male (M)/33 female (F)], 60–74 (aged, 29M/29F), and > 90 years (nonagenarian, 47M/50F). Components of the metabolic syndrome, cardiova
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1926a3bf088169270617f12e9fdbab10
https://hdl.handle.net/10919/73473
https://hdl.handle.net/10919/73473
Autor:
Johannsen, Dl, Delany, Jp, Frisard, Mi, Welsch, Ma, Rowley, Ck, Fang, X, Jazwinski, Sm, Ravussin, E., Ermolao, Andrea
Physical activity (PA) is known to decline with age; however, there is a paucity of data on activity in persons who are in their nineties and beyond. We used objective and reliable methods to measure PA in nonagenarians (≥90 yr; n = 98) and hypothe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02223fe42773e509d3dbe3bfb8f81549
http://hdl.handle.net/11577/2488614
http://hdl.handle.net/11577/2488614