An upstream enhancer regulates Gpihbp1 expression in a tissue-specific manner[S]

Autor: Christopher M. Allan, Patrick J. Heizer, Yiping Tu, Norma P. Sandoval, Rachel S. Jung, Jazmin E. Morales, Eniko Sajti, Ty D. Troutman, Thomas L. Saunders, Darren A. Cusanovich, Anne P. Beigneux, Casey E. Romanoski, Loren G. Fong, Stephen G. Young

Publikováno v: Journal of Lipid Research, Vol 60, Iss 4, Pp 869-879 (2019)

Glycosylphosphatidylinositol-anchored high density lipoprotein–binding protein 1 (GPIHBP1), the protein that shuttles LPL to the capillary lumen, is essential for plasma triglyceride metabolism. When GPIHBP1 is absent, LPL remains stranded within t

Externí odkaz: https://doaj.org/article/24c19b72c23b4571b22124accec34bdf

Deficiency in ZMPSTE24 and resulting farnesyl–prelamin A accumulation only modestly affect mouse adipose tissue stores

Autor: Loren G. Fong, Pieter J. de Jong, Paul Kim, Nicholas Jackson, Jazmin E. Morales, Yuko Yoshinaga, Patrick J. Heizer, Yan Hu, Ye Yang, Karen Reue, Stephen G. Young, Natalie Y. Chen, Yiping Tu, Robert L. Li, Laurent Vergnes

Publikováno v: J Lipid Res
Journal of Lipid Research, Vol 61, Iss 3, Pp 413-421 (2020)

Zinc metallopeptidase STE24 (ZMPSTE24) is essential for the conversion of farnesyl–prelamin A to mature lamin A, a key component of the nuclear lamina. In the absence of ZMPSTE24, farnesyl–prelamin A accumulates in the nucleus and exerts toxicity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91fffcd94c9430392135240723c4f753
https://doi.org/10.1194/jlr.ra119000593

The structural basis for monoclonal antibody 5D2 binding to the tryptophan-rich loop of lipoprotein lipase

Autor: Stephen G. Young, Michael Ploug, Thomas Cottle, Christopher M. Allan, Yiping Tu, DeeAnn K. Asamoto, Judy E. Kim, Wenxin Song, Muthuraman Meiyappan, Loren G. Fong, Cuiwen He, Jazmin E. Morales, Gabriel Birrane, Adam Kwok, J.G. Luz, Anne P. Beigneux

Publikováno v: Journal of lipid research, vol 61, iss 10
Journal of Lipid Research, Vol 61, Iss 10, Pp 1347-1359 (2020)
Luz, J, Beigneux, A P, Asamoto, D K, He, C, Song, W, Allan, C M, Morales, J E, Tu, Y, Kwok, A, Cottle, T, Meiyappan, M, Fong, L G, Kim, J, Ploug, M, Young, S G & Birrane, G 2020, ' The structural basis for monoclonal antibody 5D2 binding to the tryptophan-rich loop of lipoprotein lipase ', Journal of Lipid Research, vol. 61, no. 10, pp. 1347-1359 . https://doi.org/10.1194/jlr.RA120000993
J Lipid Res

For three decades, the lipoprotein lipase (LPL)-specific monoclonal antibody 5D2 has been used to investigate LPL structure/function and intravascular lipolysis. 5D2 has been used to measure LPL levels, block the triglyceride hydrolase activity of LP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3ee1923dc4ca97066b417156ef0ae5b
https://escholarship.org/uc/item/03p650j9