Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Jayu Jen"'
Publikováno v:
Molecular Cancer, Vol 16, Iss 1, Pp 1-12 (2017)
Abstract Background Oct4, a key stemness transcription factor, is overexpressed in lung cancer. Here, we reveal a novel transcription regulation of long non-coding RNAs (lncRNAs) by Oct4. LncRNAs have emerged as important players in cancer progressio
Externí odkaz:
https://doaj.org/article/737df2ebd41744e3b82c5445dce1a1b7
Autor:
Benjamin G. Neel, Alireza Khodadadi-Jamayran, Benjamin Haibe-Kains, Abhyudai Singh, Jason Moffat, Beatrix Ueberheide, Aristotelis Tsirigos, Jane A. Skok, Adriana Heguy, Peter Meyn, Sylvia Adams, Kwok-kin Wong, Jiehui Deng, Christos Sotiriou, David Venet, Kwan Ho Tang, Avantika Dhabaria, Allison M.L. Nixon, Kevin R. Brown, Arvind Singh Mer, Azin Sayad, Shaowen Jiang, Jayu Jen, Chewei Anderson Chang
Supplementary Figure from Ontogeny and Vulnerabilities of Drug-Tolerant Persisters in HER2+ Breast Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f1d61f7488bdc949f6ca073d647a681
https://doi.org/10.1158/2159-8290.22541321
https://doi.org/10.1158/2159-8290.22541321
Autor:
Benjamin G. Neel, Alireza Khodadadi-Jamayran, Benjamin Haibe-Kains, Abhyudai Singh, Jason Moffat, Beatrix Ueberheide, Aristotelis Tsirigos, Jane A. Skok, Adriana Heguy, Peter Meyn, Sylvia Adams, Kwok-kin Wong, Jiehui Deng, Christos Sotiriou, David Venet, Kwan Ho Tang, Avantika Dhabaria, Allison M.L. Nixon, Kevin R. Brown, Arvind Singh Mer, Azin Sayad, Shaowen Jiang, Jayu Jen, Chewei Anderson Chang
Resistance to targeted therapies is an important clinical problem in HER2-positive (HER2+) breast cancer. “Drug-tolerant persisters” (DTP), a subpopulation of cancer cells that survive via reversible, nongenetic mechanisms, are implicated in resi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48d194ed501ee311f5f4087871350c4b
https://doi.org/10.1158/2159-8290.c.6549611
https://doi.org/10.1158/2159-8290.c.6549611
Autor:
Benjamin G. Neel, Alireza Khodadadi-Jamayran, Benjamin Haibe-Kains, Abhyudai Singh, Jason Moffat, Beatrix Ueberheide, Aristotelis Tsirigos, Jane A. Skok, Adriana Heguy, Peter Meyn, Sylvia Adams, Kwok-kin Wong, Jiehui Deng, Christos Sotiriou, David Venet, Kwan Ho Tang, Avantika Dhabaria, Allison M.L. Nixon, Kevin R. Brown, Arvind Singh Mer, Azin Sayad, Shaowen Jiang, Jayu Jen, Chewei Anderson Chang
Supplementary Table from Ontogeny and Vulnerabilities of Drug-Tolerant Persisters in HER2+ Breast Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5211c05ab0a7ee0d441cbd8dd886216d
https://doi.org/10.1158/2159-8290.22541315
https://doi.org/10.1158/2159-8290.22541315
Autor:
Kwan Ho Tang, Benjamin G. Neel, George Miller, Diane M. Simeone, Ugur Ozerdem, Kiyomi Araki, Mitchell J. Geer, Jayu Jen, Wei Wei, Brian Diskin, Hao Ran, Carmine Fedele
Supplementary table and figure legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00581488eca16de7933d3f86baa635f8
https://doi.org/10.1158/2159-8290.22531949.v1
https://doi.org/10.1158/2159-8290.22531949.v1
Autor:
Benjamin G. Neel, Kwok-Kin Wong, Aristotelis Tsirigos, Cynthia A. Loomis, Argus Athanas, Peter Olson, James G. Christensen, Dean Y. Maeda, John A. Zebala, Carmine Fedele, Yuan Hao, Ting Chen, Kayla Guidry, Han Han, Jayu Jen, Alireza Khodadadi-Jamayran, Shuai Li, Kwan Ho Tang
SHP2 inhibitors (SHP2i) alone and in various combinations are being tested in multiple tumors with overactivation of the RAS/ERK pathway. SHP2 plays critical roles in normal cell signaling; hence, SHP2is could influence the tumor microenvironment. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ac5bb67a60ff5aa42b51919267a87ea
https://doi.org/10.1158/2159-8290.c.6549436.v1
https://doi.org/10.1158/2159-8290.c.6549436.v1
Autor:
Benjamin G. Neel, Kwok-Kin Wong, Aristotelis Tsirigos, Cynthia A. Loomis, Argus Athanas, Peter Olson, James G. Christensen, Dean Y. Maeda, John A. Zebala, Carmine Fedele, Yuan Hao, Ting Chen, Kayla Guidry, Han Han, Jayu Jen, Alireza Khodadadi-Jamayran, Shuai Li, Kwan Ho Tang
Table S7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07fbd70898706deb6c68333d4b97a8f4
https://doi.org/10.1158/2159-8290.22540627
https://doi.org/10.1158/2159-8290.22540627
Autor:
Kwan Ho Tang, Benjamin G. Neel, George Miller, Diane M. Simeone, Ugur Ozerdem, Kiyomi Araki, Mitchell J. Geer, Jayu Jen, Wei Wei, Brian Diskin, Hao Ran, Carmine Fedele
Table S1: Bliss Index for Effect of MEK-I/SHP099 Combination on Cancer Cell Proliferation Table S2: Primer Sequences for qRT-PCR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c23d243932f6fcebfc9cce6cb46aa0a
https://doi.org/10.1158/2159-8290.22531946
https://doi.org/10.1158/2159-8290.22531946
Figure S1-6 from Combined Inhibition of SHP2 and CXCR1/2 Promotes Antitumor T-cell Response in NSCLC
Autor:
Benjamin G. Neel, Kwok-Kin Wong, Aristotelis Tsirigos, Cynthia A. Loomis, Argus Athanas, Peter Olson, James G. Christensen, Dean Y. Maeda, John A. Zebala, Carmine Fedele, Yuan Hao, Ting Chen, Kayla Guidry, Han Han, Jayu Jen, Alireza Khodadadi-Jamayran, Shuai Li, Kwan Ho Tang
Figure S1-6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3db55b1f7b0adeca862191754700aa35
https://doi.org/10.1158/2159-8290.22540636.v1
https://doi.org/10.1158/2159-8290.22540636.v1
Autor:
Kwan Ho Tang, Benjamin G. Neel, George Miller, Diane M. Simeone, Ugur Ozerdem, Kiyomi Araki, Mitchell J. Geer, Jayu Jen, Wei Wei, Brian Diskin, Hao Ran, Carmine Fedele
Supplementary Figure S1: Combined SHP2/MEK inhibition prevents adaptive resistance in PDAC and NSCLC lines Supplementary Figure S2: SHP2 inhibition abrogates MEK-I-evoked reactivation of the ERK MAPK pathway Supplementary Figure S3: Distinct mechanis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::810ef475009276888f51939c16b4e4fb
https://doi.org/10.1158/2159-8290.22531955
https://doi.org/10.1158/2159-8290.22531955