Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Jayron J. Habibe"'
Autor:
Jayron J. Habibe, Ulrika Boulund, Maria P. Clemente-Olivo, Carlie J. M. de Vries, Etto C. Eringa, Max Nieuwdorp, Bart Ferwerda, Koos Zwinderman, Bert-Jan H. van den Born, Henrike Galenkamp, Daniel H. van Raalte
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 5, p 4332 (2023)
Type 2 diabetes mellitus (T2D) is a prevalent disease often accompanied by the occurrence of dyslipidemia. Four and a half LIM domains 2 (FHL2) is a scaffolding protein, whose involvement in metabolic disease has recently been demonstrated. The assoc
Externí odkaz:
https://doaj.org/article/0f4a37c545a2467dbc45b02802214713
Publikováno v:
Cells, Vol 10, Iss 10, p 2611 (2021)
Susceptibility to complex pathological conditions such as obesity, type 2 diabetes and cardiovascular disease is highly variable among individuals and arises from specific changes in gene expression in combination with external factors. The regulatio
Externí odkaz:
https://doaj.org/article/9cbbba4e6f494da7a8261404702b43b5
Autor:
Jayron J. Habibe, Maria P. Clemente-Olivo, Torsten P. M. Scheithauer, Elena Rampanelli, Hilde Herrema, Mariska Vos, Arnout Mieremet, Max Nieuwdorp, Daniel H. van Raalte, Etto C. Eringa, Carlie J. M. de Vries
Publikováno v:
Diabetologia, 65(10):s00125-022-05750-1, 1721-1733. Springer, Cham
Diabetologia, 65(10), 1721-1733. Springer Verlag
Habibe, J J, Clemente-Olivo, M P, Scheithauer, T P M, Rampanelli, E, Herrema, H, Vos, M, Mieremet, A, Nieuwdorp, M, van Raalte, D H, Eringa, E C & de Vries, C J M 2022, ' Glucose-mediated insulin secretion is improved in FHL2-deficient mice and elevated FHL2 expression in humans is associated with type 2 diabetes ', Diabetologia, vol. 65, no. 10, pp. 1721-1733 . https://doi.org/10.1007/s00125-022-05750-1
Diabetologia, 65(10), 1721-1733. Springer Verlag
Habibe, J J, Clemente-Olivo, M P, Scheithauer, T P M, Rampanelli, E, Herrema, H, Vos, M, Mieremet, A, Nieuwdorp, M, van Raalte, D H, Eringa, E C & de Vries, C J M 2022, ' Glucose-mediated insulin secretion is improved in FHL2-deficient mice and elevated FHL2 expression in humans is associated with type 2 diabetes ', Diabetologia, vol. 65, no. 10, pp. 1721-1733 . https://doi.org/10.1007/s00125-022-05750-1
Aims/hypothesis The general population is ageing, involving an enhanced incidence of chronic diseases such as type 2 diabetes. With ageing, DNA methylation of FHL2 increases, as well as expression of the four and a half LIM domains 2 (FHL2) protein i
Autor:
Patrick C.N. Rensen, Carlie J.M. de Vries, Jayron J. Habibe, Sander Kooijman, Hilde Herrema, Mariska Vos, Maria P. Clemente-Olivo, Roelof Ottenhoff, Max Nieuwdorp, Noam Zelcer, Aldo Jongejan, Etto C. Eringa, Daniël H. van Raalte
Publikováno v:
Metabolism: clinical and experimental, 121:154815. W.B. Saunders Ltd
Clemente-Olivo, M P, Habibe, J J, Vos, M, Ottenhoff, R, Jongejan, A, Herrema, H, Zelcer, N, Kooijman, S, Rensen, P C N, van Raalte, D H, Nieuwdorp, M, Eringa, E C & de Vries, C J 2021, ' Four-and-a-half LIM domain protein 2 (FHL2) deficiency protects mice from diet-induced obesity and high FHL2 expression marks human obesity ', Metabolism: Clinical and Experimental, vol. 121, 154815, pp. 1-14 . https://doi.org/10.1016/j.metabol.2021.154815
Metabolism
Metabolism: Clinical and Experimental, 121:154815, 1-14. W.B. Saunders Ltd
Metabolism, 121. W B SAUNDERS CO-ELSEVIER INC
Clemente-Olivo, M P, Habibe, J J, Vos, M, Ottenhoff, R, Jongejan, A, Herrema, H, Zelcer, N, Kooijman, S, Rensen, P C N, van Raalte, D H, Nieuwdorp, M, Eringa, E C & de Vries, C J 2021, ' Four-and-a-half LIM domain protein 2 (FHL2) deficiency protects mice from diet-induced obesity and high FHL2 expression marks human obesity ', Metabolism: Clinical and Experimental, vol. 121, 154815, pp. 1-14 . https://doi.org/10.1016/j.metabol.2021.154815
Metabolism
Metabolism: Clinical and Experimental, 121:154815, 1-14. W.B. Saunders Ltd
Metabolism, 121. W B SAUNDERS CO-ELSEVIER INC
Objective: Four-and-a-Half-LIM-domain-protein 2 (FHL2) modulates multiple signal transduction pathways but has not been implicated in obesity or energy metabolism. In humans, methylation and expression of the FHL2 gene increases with age, and high FH