Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Jayne E. Murray"'
Autor:
Jayne E. Murray, Emanuele Valli, Giorgio Milazzo, Chelsea Mayoh, Andrew J. Gifford, Jamie I. Fletcher, Chengyuan Xue, Nisitha Jayatilleke, Firoozeh Salehzadeh, Laura D. Gamble, Jourdin R. C. Rouaen, Daniel R. Carter, Helen Forgham, Eric O. Sekyere, Joanna Keating, Georgina Eden, Sophie Allan, Stephanie Alfred, Frances K. Kusuma, Ashleigh Clark, Hannah Webber, Amanda J. Russell, Antoine de Weck, Benjamin T. Kile, Martina Santulli, Piergiuseppe De Rosa, Emmy D. G. Fleuren, Weiman Gao, Lorna Wilkinson-White, Jason K. K. Low, Joel P. Mackay, Glenn M. Marshall, Douglas J. Hilton, Federico M. Giorgi, Jan Koster, Giovanni Perini, Michelle Haber, Murray D. Norris
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract MYCN oncogene amplification is frequently observed in aggressive childhood neuroblastoma. Using an unbiased large-scale mutagenesis screen in neuroblastoma-prone transgenic mice, we identify a single germline point mutation in the transcript
Externí odkaz:
https://doaj.org/article/ee532e0c05a8415d9de099a04d9f475c
Autor:
Glenn M. Marshall, Belamy B. Cheung, Michael W. Parker, Giovanni Perini, Jamie I. Fletcher, Murray D. Norris, Michelle Haber, W. Clay Gustafson, Shizhen Zhu, Xiaoling Zhang, Tao Liu, Andrew J. Gifford, Matthias Fischer, Andre Oberthuer, Stefan Hüttelmaier, Larissa Doughty, Jessica L. Bell, Michael A. Gorman, Brendan W. Stevenson, Bryce Keenan, Chelsea Mayoh, Bing Liu, Joshua A. McCarroll, Jayne E. Murray, Giorgio Milazzo, Janith A. Seneviratne, Taylor Lim, Mika Herath, Olivia C. Ciampa, Daniel R. Carter, Hassina Massudi, Jessica K. Holien, Jessica Koach
Supplementary Figure S1. PA2G4 is a MYCN transactivation target gene. A, Quantification of protein expression using anti-PA2G4 and anti-MYCN antibodies against whole cell protein lysates from BE(2)-C and Kelly cells, following MYCN siRNA knockdown fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60025d7d24b347241cbbcf5c562a70ea
https://doi.org/10.1158/0008-5472.22426183.v1
https://doi.org/10.1158/0008-5472.22426183.v1
Autor:
Glenn M. Marshall, Belamy B. Cheung, Michael W. Parker, Giovanni Perini, Jamie I. Fletcher, Murray D. Norris, Michelle Haber, W. Clay Gustafson, Shizhen Zhu, Xiaoling Zhang, Tao Liu, Andrew J. Gifford, Matthias Fischer, Andre Oberthuer, Stefan Hüttelmaier, Larissa Doughty, Jessica L. Bell, Michael A. Gorman, Brendan W. Stevenson, Bryce Keenan, Chelsea Mayoh, Bing Liu, Joshua A. McCarroll, Jayne E. Murray, Giorgio Milazzo, Janith A. Seneviratne, Taylor Lim, Mika Herath, Olivia C. Ciampa, Daniel R. Carter, Hassina Massudi, Jessica K. Holien, Jessica Koach
Supplementary Figure S1. F, Confocal microscopy of SHEP Tet21N cells using anti-PA2G4 (red) and anti-MYCN (green) antibodies. G, Immunoblot analysis of cytoplasmic and nuclear fractions from BE(2)-C and Kelly human neuroblastoma cell lines with antib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d30f1f6671b089f475263f614b3c030
https://doi.org/10.1158/0008-5472.22426180
https://doi.org/10.1158/0008-5472.22426180
Autor:
Glenn M. Marshall, Belamy B. Cheung, Michael W. Parker, Giovanni Perini, Jamie I. Fletcher, Murray D. Norris, Michelle Haber, W. Clay Gustafson, Shizhen Zhu, Xiaoling Zhang, Tao Liu, Andrew J. Gifford, Matthias Fischer, Andre Oberthuer, Stefan Hüttelmaier, Larissa Doughty, Jessica L. Bell, Michael A. Gorman, Brendan W. Stevenson, Bryce Keenan, Chelsea Mayoh, Bing Liu, Joshua A. McCarroll, Jayne E. Murray, Giorgio Milazzo, Janith A. Seneviratne, Taylor Lim, Mika Herath, Olivia C. Ciampa, Daniel R. Carter, Hassina Massudi, Jessica K. Holien, Jessica Koach
MYCN is a major driver for the childhood cancer, neuroblastoma, however, there are no inhibitors of this target. Enhanced MYCN protein stability is a key component of MYCN oncogenesis and is maintained by multiple feedforward expression loops involvi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7722c088528eae6f7ee7e960f9d8b68
https://doi.org/10.1158/0008-5472.c.6512245
https://doi.org/10.1158/0008-5472.c.6512245
Autor:
Orazio Vittorio, Maria Kavallaris, Joseph A. Trapani, Michelle Haber, Paul A. Beavis, Chelsea Mayoh, Giuseppe Cirillo, Aria Ahmed-Cox, Jayne E. Murray, Sylvie Shen, Jourdin R.C. Rouaen, Daniele Mercatelli, Federico M. Giorgi, Federica Saletta, Kathleen Kimpton, Luigi Lerra, Emanuele Valli, Florida Voli
Therapeutic checkpoint antibodies blocking programmed death receptor 1/programmed death ligand 1 (PD-L1) signaling have radically improved clinical outcomes in cancer. However, the regulation of PD-L1 expression on tumor cells is still poorly underst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b59dc19bdbc7cf8bb8c04b3287ba0ae
https://doi.org/10.1158/0008-5472.c.6512334.v1
https://doi.org/10.1158/0008-5472.c.6512334.v1
Autor:
Glenn M. Marshall, Belamy B. Cheung, Michael W. Parker, Giovanni Perini, Jamie I. Fletcher, Murray D. Norris, Michelle Haber, W. Clay Gustafson, Shizhen Zhu, Xiaoling Zhang, Tao Liu, Andrew J. Gifford, Matthias Fischer, Andre Oberthuer, Stefan Hüttelmaier, Larissa Doughty, Jessica L. Bell, Michael A. Gorman, Brendan W. Stevenson, Bryce Keenan, Chelsea Mayoh, Bing Liu, Joshua A. McCarroll, Jayne E. Murray, Giorgio Milazzo, Janith A. Seneviratne, Taylor Lim, Mika Herath, Olivia C. Ciampa, Daniel R. Carter, Hassina Massudi, Jessica K. Holien, Jessica Koach
Supplementary Figure S2. PA2G4 increases MYCN protein stability. A and B, Representative immunoblots from cycloheximide (CHX) chase assays measuring the half-life of MYCN protein after PA2G4 knockdown (A) or overexpression (B) in BE(2)-C and Kelly ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::675af2bb1954e0b11b9f6bc816b84b2a
https://doi.org/10.1158/0008-5472.22426177.v1
https://doi.org/10.1158/0008-5472.22426177.v1
Autor:
Orazio Vittorio, Maria Kavallaris, Joseph A. Trapani, Michelle Haber, Paul A. Beavis, Chelsea Mayoh, Giuseppe Cirillo, Aria Ahmed-Cox, Jayne E. Murray, Sylvie Shen, Jourdin R.C. Rouaen, Daniele Mercatelli, Federico M. Giorgi, Federica Saletta, Kathleen Kimpton, Luigi Lerra, Emanuele Valli, Florida Voli
DC increases tumor-infiltrating immune cells in Th-MYCN mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b49072c94b33108ec725c1c6c244f81
https://doi.org/10.1158/0008-5472.22426428.v1
https://doi.org/10.1158/0008-5472.22426428.v1
Autor:
Glenn M. Marshall, Belamy B. Cheung, Michael W. Parker, Giovanni Perini, Jamie I. Fletcher, Murray D. Norris, Michelle Haber, W. Clay Gustafson, Shizhen Zhu, Xiaoling Zhang, Tao Liu, Andrew J. Gifford, Matthias Fischer, Andre Oberthuer, Stefan Hüttelmaier, Larissa Doughty, Jessica L. Bell, Michael A. Gorman, Brendan W. Stevenson, Bryce Keenan, Chelsea Mayoh, Bing Liu, Joshua A. McCarroll, Jayne E. Murray, Giorgio Milazzo, Janith A. Seneviratne, Taylor Lim, Mika Herath, Olivia C. Ciampa, Daniel R. Carter, Hassina Massudi, Jessica K. Holien, Jessica Koach
Supplementary Information
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c2b8ede76bf0ab8f04eadb6832eefa9
https://doi.org/10.1158/0008-5472.22426153.v1
https://doi.org/10.1158/0008-5472.22426153.v1
Autor:
Glenn M. Marshall, Belamy B. Cheung, Michael W. Parker, Giovanni Perini, Jamie I. Fletcher, Murray D. Norris, Michelle Haber, W. Clay Gustafson, Shizhen Zhu, Xiaoling Zhang, Tao Liu, Andrew J. Gifford, Matthias Fischer, Andre Oberthuer, Stefan Hüttelmaier, Larissa Doughty, Jessica L. Bell, Michael A. Gorman, Brendan W. Stevenson, Bryce Keenan, Chelsea Mayoh, Bing Liu, Joshua A. McCarroll, Jayne E. Murray, Giorgio Milazzo, Janith A. Seneviratne, Taylor Lim, Mika Herath, Olivia C. Ciampa, Daniel R. Carter, Hassina Massudi, Jessica K. Holien, Jessica Koach
Supplementary Figure S6. PA2G4 increases neuroblastoma tumorigenicity. A, Representative images of athymic nude mice inoculated with neuroblastoma (SH-EP) cells stably transfected with either EV control or a PA2G4 expression vector at 10 weeks post-i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cfa8995ffc3b6677c9a9bb42025eedf
https://doi.org/10.1158/0008-5472.22426159.v1
https://doi.org/10.1158/0008-5472.22426159.v1
Autor:
Glenn M. Marshall, Belamy B. Cheung, Michael W. Parker, Giovanni Perini, Jamie I. Fletcher, Murray D. Norris, Michelle Haber, W. Clay Gustafson, Shizhen Zhu, Xiaoling Zhang, Tao Liu, Andrew J. Gifford, Matthias Fischer, Andre Oberthuer, Stefan Hüttelmaier, Larissa Doughty, Jessica L. Bell, Michael A. Gorman, Brendan W. Stevenson, Bryce Keenan, Chelsea Mayoh, Bing Liu, Joshua A. McCarroll, Jayne E. Murray, Giorgio Milazzo, Janith A. Seneviratne, Taylor Lim, Mika Herath, Olivia C. Ciampa, Daniel R. Carter, Hassina Massudi, Jessica K. Holien, Jessica Koach
Supplementary Figure S5 F-H F), at 72 hours post-transfection of EV or a PA2G4 expression vector. G, Cell viability measured by the Alamar Blue assay and immunoblot analyses using an antibody identifying MYC-tagged PA2G4-p42 protein expression in Kel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89c87f2b748626138c69fb866d0ba82f
https://doi.org/10.1158/0008-5472.22426162.v1
https://doi.org/10.1158/0008-5472.22426162.v1