Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Jayne C, Boyer"'
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract The isocyanate monomer 1,6-hexamethylene diisocyanate (HDI) and one of its trimers, HDI isocyanurate, are airway and skin sensitizers contained in polyurethane paint. The toxic response of cultured skin cells to these compounds was measured
Externí odkaz:
https://doaj.org/article/337d6a2b15b749ac8c9749d5c276e4d7
Autor:
Laura W. Taylor, John E. French, Zachary G. Robbins, Jayne C. Boyer, Leena A. Nylander-French
Publikováno v:
Frontiers in Genetics, Vol 11 (2020)
We evaluated the impact of genetic variance on biomarker levels in a population of workers in the automotive repair and refinishing industry who were exposed to respiratory sensitizers 1,6-hexamethylene diisocyanate (HDI) monomer and one of its trime
Externí odkaz:
https://doaj.org/article/dea3f65f7b7f44d9be704194ae36f352
Autor:
Natalie Saini, Steven A Roberts, Leszek J Klimczak, Kin Chan, Sara A Grimm, Shuangshuang Dai, David C Fargo, Jayne C Boyer, William K Kaufmann, Jack A Taylor, Eunjung Lee, Isidro Cortes-Ciriano, Peter J Park, Shepherd H Schurman, Ewa P Malc, Piotr A Mieczkowski, Dmitry A Gordenin
Publikováno v:
PLoS Genetics, Vol 12, Iss 10, p e1006385 (2016)
Accumulation of somatic changes, due to environmental and endogenous lesions, in the human genome is associated with aging and cancer. Understanding the impacts of these processes on mutagenesis is fundamental to understanding the etiology, and impro
Externí odkaz:
https://doaj.org/article/148d642d05be4115befb367ef75ad6b5
Autor:
Michael C. Madden, Leena A. Nylander-French, Joachim D. Pleil, M. Ariel Geer Wallace, Jayne C. Boyer, Brett R Winters
Publikováno v:
Applied In Vitro Toxicology. 4:129-138
Due to the ∼86,000 chemicals registered under the Toxic Substances Control Act and increasing ethical concerns regarding animal testing, it is not economically or technically feasible to screen every registered chemical for toxicity using animal-ba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::21701efb0f565c853e50677f9d55303d
https://doi.org/10.1089/aivt.2017.0038
https://doi.org/10.1089/aivt.2017.0038
Autor:
Brett R, Winters, Joachim D, Pleil, Jayne C, Boyer, Leena A, Nylander-French, M Ariel Geer, Wallace, Michael C, Madden
Publikováno v:
Applied in vitro toxicology. 4(2)
Due to the approximately 86,000 chemicals registered under the Toxic Substances Control Act and increasing ethical concerns regarding animal testing, it is not economically or technically feasible to screen every registered chemical for toxicity usin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9d451a35a213c4e7ff481be4697c6a69
https://pubmed.ncbi.nlm.nih.gov/31037250
https://pubmed.ncbi.nlm.nih.gov/31037250
Publikováno v:
ISEE Conference Abstracts. 2018
Polyurethane spray-painting can result in significant occupational exposure to 1,6-hexamethylene diisocyanate (HDI) monomer and its trimer, HDI isocyanurate. Inter-individual genetic differences ha...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d7b06da038ee38313a8150db5d427996
https://doi.org/10.1289/isesisee.2018.o03.03.25
https://doi.org/10.1289/isesisee.2018.o03.03.25
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 640:89-96
Although microsatellite mutation rates generally increase with increasing length of the repeat tract, interruptions in a microsatellite may stabilize it. We have performed a direct analysis of the effect of microsatellite interruptions on mutation ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45677fca805c12210a16cbb8caca5e9e
https://doi.org/10.1016/j.mrfmmm.2007.12.005
https://doi.org/10.1016/j.mrfmmm.2007.12.005
Autor:
William K. Kaufmann, Marila Cordeiro-Stone, Taiyi Jin, Yingchun Zhou, Jayne C. Boyer, Bo Chen, Feng Cao, Tong Zhou, Dennis A. Simpson
Publikováno v:
Toxicology and Applied Pharmacology. 218:174-185
This study focused on the activation of cell cycle checkpoint responses in diploid human fibroblasts that were treated with cadmium chloride and the potential roles of ATM and p53 signaling pathways in cadmium-induced responses. The alkaline comet as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4ab5b8e63750a27f3c444f53c90b599
https://doi.org/10.1016/j.taap.2006.10.031
https://doi.org/10.1016/j.taap.2006.10.031
Autor:
Leena A. Nylander-French, Lisa Smeester, Michael C. Wu, Jayne C. Boyer, Rebecca C. Fry, John E. French, Alison P. Sanders
Publikováno v:
Toxicol Lett
DNA methylation may mediate inter-individual responses to chemical exposure and, thus, modify biomarker levels of exposure and effects. We analyzed inter-individual differences in inhalation and skin exposure to 1,6-hexamethylene diisocyanate (HDI) a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b350a257666836c952646e9821c89606
https://europepmc.org/articles/PMC8060918/
https://europepmc.org/articles/PMC8060918/
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 429:149-158
We have used 8-O-dGTP, a mutagenic nucleotide generated by oxidative metabolism, to probe the misincorporation potential of HIV-1 reverse transcriptase (RT) during DNA synthesis templated by the same nucleotide sequence as either RNA or DNA. With eit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8b829330a8b427f1f345d6607c69e13
https://doi.org/10.1016/s0027-5107(99)00119-0
https://doi.org/10.1016/s0027-5107(99)00119-0