Výsledky vyhledávání - "Jayne B. Tracey"

Reversibility of severe metabolic stress in stored platelets after in vitro plasma rescue or in vivo transfusion: restoration of secretory function and maintenance of platelet survival

Autor: Jayne B. Tracey, Henry M. Rinder, Chao Wang, Edward L. Snyder, Laurence Baril, Christine S. Rinder, Brian R. Smith, Dorothy M. Dincecco

Publikováno v: Transfusion. 43:1230-1237

BACKGROUND: Determining reversible aspects of the platelet storage lesion may result in improved function and survival of transfused platelets. STUDY DESIGN AND METHODS: Using a model of high-dose (apheresis-derived) platelet concentrates (PC), funct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ccfb2662723712de3651d0a1c5f2a3e0
https://doi.org/10.1046/j.1537-2995.2003.00484.x

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Effects of Meloxicam on Platelet Function in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled Trial

Autor: Henry M. Rinder, Chao Wang, Chester C. Wood, Jayne B. Tracey, R. Paul Gagnier, Magdalena Souhrada

Publikováno v: The Journal of Clinical Pharmacology. 42:881-886

Nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit cyclooxygenase-1 (COX-1), thereby inhibiting platelet function via blockade of thromboxane A2 (TxA2) formation, and COX-2, the enzyme that mediates inflammatory responses. Meloxicam is a relativel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91f52d9903d0f4249c51676d80bd16ce
https://doi.org/10.1177/009127002401102795

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The Effects of Heparin, Protamine, and Heparin/Protamine Reversal on Platelet Function Under Conditions of Arterial Shear Stress

Autor: Brian R. Smith, Christine S. Rinder, Nancy Kriz, Conan K. Li, Michael J. Griffin, Henry M. Rinder, Jayne B. Tracey

Publikováno v: Anesthesia & Analgesia. 93:20-27

UNLABELLED Platelet dysfunction contributes to blood loss after cardiopulmonary bypass. This study examined the antiplatelet effects of heparin, protamine, and varying heparin/protamine ratios in an in vitro physiologic model and further elucidated t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56d65c053d653c7fc1bf0154ce0c6918
https://doi.org/10.1097/00000539-200107000-00005

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Selective blockade of membrane attack complex formation during simulated extracorporeal circulation inhibits platelet but not leukocyte activation

Autor: Brian R. Smith, Jayne B. Tracey, M. Smith, Jane C. K. Fitch, Lan Li, Christine S. Rinder, Henry M. Rinder, Scott A. Rollins

Publikováno v: The Journal of Thoracic and Cardiovascular Surgery. 118:460-466

Objective: Complement activation is induced by cardiopulmonary bypass, and previous work found that late complement components (C5a, C5b-9) contribute to neutrophil and platelet activation during bypass. In the present study, we blocked C5b-9 formati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ecbe9ac9e02fa3de03c611e2a8add90
https://doi.org/10.1016/s0022-5223(99)70183-2

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Differences in Platelet α-granule Release between Normals and Immune Thrombocytopenic Patients and between Young and Old Platelets

Autor: Laura DeCastro, Colleen McHugh, Christine S. Rinder, Jayne B. Tracey, Henry M. Rinder, Michael Recht, Brian R. Smith

Publikováno v: Thrombosis and Haemostasis. 80:457-462

SummaryThe risk of serious bleeding in patients with immune thrombocytopenic purpura (ITP) appears to be less than in comparably thrombocytopenic patients with megakaryocytic hypoplasia. It has been proposed that this difference is due to enhanced he

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c029a0c75c138c5099bddf337bc4caac
https://doi.org/10.1055/s-0037-1615229

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Blockade of C5a and C5b-9 generation inhibits leukocyte and platelet activation during extracorporeal circulation

Autor: Henry M. Rinder, Scott A. Rollins, M. Smith, Stephen P. Squinto, Brian R. Smith, Christine S. Rinder, Louis A. Matis, Jayne B. Tracey, Jane C. K. Fitch

Publikováno v: Journal of Clinical Investigation. 96:1564-1572

Complement activation contributes to the systemic inflammatory response induced by cardiopulmonary bypass. At the cellular level, cardiopulmonary bypass activates leukocytes and platelets; however the contribution of early (3a) versus late (C5a, solu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8593eb33c7cba02c258df1179ea0c22
https://doi.org/10.1172/jci118195

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Antithrombin reduces monocyte and neutrophil CD11b up regulation in addition to blocking platelet activation during extracorporeal circulation

Autor: Michael J. Smith, Christine S. Rinder, Brian R. Smith, Jane C. K. Fitch, Jayne B. Tracey, Scott A. Rollins, Wayne L. Chandler, Henry M. Rinder

Publikováno v: Transfusion. 46(7)

BACKGROUND: Patients undergoing cardiac surgery requiring cardiopulmonary bypass develop a systemic inflammatory reaction. Antithrombin III (AT) has anticoagulant effects but also shows evidence of anti-inflammatory activity. The aim of this study wa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d90d45909810f3cb510e605861e8bd9a
https://pubmed.ncbi.nlm.nih.gov/16836559

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Reversibility of severe metabolic stress in stored platelets after in vitro plasma rescue or in vivo transfusion: restoration of secretory function and maintenance of platelet survival

Autor: Henry M, Rinder, Edward L, Snyder, Jayne B, Tracey, Dorothy, Dincecco, Chao, Wang, Laurence, Baril, Christine S, Rinder, Brian R, Smith

Publikováno v: Transfusion. 43(9)

Determining reversible aspects of the platelet storage lesion may result in improved function and survival of transfused platelets.Using a model of high-dose (apheresis-derived) platelet concentrates (PC), functional changes imposed by transient adve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c9459dd44be383903a73b53814823669
https://pubmed.ncbi.nlm.nih.gov/12919425

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Xenotransplantation of immunodeficient mice with mobilized human blood CD34+ cells provides an in vivo model for human megakaryocytopoiesis and platelet production

Autor: Jayne B. Tracey, Henry M. Rinder, Lia Perez, Chao Wang, Diane S. Krause, Noel Maun

Publikováno v: Blood. 97(6)

The study of megakaryocytopoiesis has been based largely on in vitro assays. We characterize an in vivo model of megakaryocyte and platelet development in which human peripheral blood stem cells (PBSCs) differentiate along megakaryocytic as well as m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28bbf80847e776ec7deb6a105398b693
https://pubmed.ncbi.nlm.nih.gov/11238102

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Role of C3 cleavage in monocyte activation during extracorporeal circulation

Autor: Henry M. Rinder, Glenda Polack, Christine S. Rinder, Brian R. Smith, David L. Lee, Jayne B. Tracey, Kirk R. Johnson, M. Smith, C. Grace Yeh, Paul Higgins

Publikováno v: Circulation. 100(5)

Background —We previously demonstrated that inhibiting formation of terminal complement components (C5a and C5b-9) prevents platelet and neutrophil (PMN) but not monocyte activation during simulated extracorporeal circulation (SECC). This study exa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0021e071f153d8b731a61d4576b9b91
https://pubmed.ncbi.nlm.nih.gov/10430771

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