P7C3 Neuroprotective Chemicals Block Axonal Degeneration and Preserve Function after Traumatic Brain Injury

Autor: Terry C. Yin, Jeremiah K. Britt, Héctor De Jesús-Cortés, Yuan Lu, Rachel M. Genova, Michael Z. Khan, Jaymie R. Voorhees, Jianqiang Shao, Aaron C. Katzman, Paula J. Huntington, Cassie Wassink, Latisha McDaniel, Elizabeth A. Newell, Laura M. Dutca, Jacinth Naidoo, Huxing Cui, Alexander G. Bassuk, Matthew M. Harper, Steven L. McKnight, Joseph M. Ready, Andrew A. Pieper

Publikováno v: Cell Reports, Vol 8, Iss 6, Pp 1731-1740 (2014)

The P7C3 class of neuroprotective aminopropyl carbazoles has been shown to block neuronal cell death in models of neurodegeneration. We now show that P7C3 molecules additionally preserve axonal integrity after injury, before neuronal cell death occur

Externí odkaz: https://doaj.org/article/eaf07f99280f4695b3055e2a7c8aa34d

(−)-P7C3-S243 Protects a Rat Model of Alzheimer’s Disease From Neuropsychiatric Deficits and Neurodegeneration Without Altering Amyloid Deposition or Reactive Glia

Autor: Michael Z. Khan, Andrew A. Pieper, Jaymie R. Voorhees, Latisha McDaniel, Matthew T. Remy, Daniel J. Brat, Noelle S. Williams, Eli El Rassi, Coral J. Cintrón-Pérez, Laura M. Dutca, Terry C. Yin

Publikováno v: Biological Psychiatry. 84:488-498

BACKGROUND: In addition to cognitive deficits, Alzheimer’s disease (AD) is also associated with other neuropsychiatric symptoms, including severe depression. Indeed, depression often precedes cognitive deficits in patients with AD. Unfortunately, t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be1e412c94f19c20f9a8fe2ea99891f0
https://doi.org/10.1016/j.biopsych.2017.10.023

Occupational-like organophosphate exposure disrupts microglia and accelerates deficits in a rat model of Alzheimer’s disease

Autor: Claire M. Erickson, Andrew A. Pieper, Matthew T. Remy, Laura M. Dutca, Jaymie R. Voorhees, Daniel J. Brat

Publikováno v: NPJ Aging and Mechanisms of Disease
npj Aging and Mechanisms of Disease, Vol 5, Iss 1, Pp 1-14 (2019)

Occupational exposure to organophosphate pesticides, such as chlorpyrifos (CPF), increases the risk of Alzheimer’s disease (AD), though the mechanism is unclear. To investigate this, we subjected 4-month-old male and female wild-type (WT) and TgF34

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25d938569fc5882caff8f21c85562ce4
http://europepmc.org/articles/PMC6342990

Endothelial Von Willebrand Factor Promotes Blood–Brain Barrier Flexibility and Provides Protection From Hypoxia and Seizures in Mice

Autor: Jaymie R. Voorhees, Jessica E. Cabral, Georgette L. Suidan, Simon F. De Meyer, Denisa D. Wagner, Alexander Brill, Stephen M. Cifuni

Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology. 33:2112-2120

Objective— Aberrant blood–brain barrier (BBB) permeability is a hallmark pathology of many central nervous system diseases. von Willebrand factor (VWF) is stored in endothelial Weibel–Palade bodies from where it is released on activation into p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e1af6949178705c6dc4f3e7fae269db
https://doi.org/10.1161/atvbaha.113.301362

Neurotoxicity in Preclinical Models of Occupational Exposure to Organophosphorus Compounds

Autor: Andrew A. Pieper, Jaymie R. Voorhees, Pamela J. Lein, Diane S. Rohlman

Publikováno v: Frontiers in Neuroscience
Voorhees, JR; Rohlman, DS; Lein, PJ; & Pieper, AA. (2017). Neurotoxicity in preclinical models of occupational exposure to organophosphorus compounds. Frontiers in Neuroscience, 10(JAN), 590. doi: 10.3389/fnins.2016.00590. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/5r94c6j5
Frontiers in neuroscience, vol 10, iss JAN

© 2017 Voorhees, Rohlman, Lein and Pieper. Organophosphorus (OPs) compounds are widely used as insecticides, plasticizers, and fuel additives. These compounds potently inhibit acetylcholinesterase (AChE), the enzyme that inactivates acetylcholine at

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf1e024ca8c102e389ea2a0b03611b0a
https://pubmed.ncbi.nlm.nih.gov/28149268