Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Jayme Lyn Roark Wilson"'
Autor:
Jennifer Poole Peckham, Wendy Y. Mills, Terrence L. Smalley, Jayme Lyn Roark Wilson, Andrew J. Peat, Scott Howard Dickerson, Tony Y. Wang, Dulce Garrido, Stephanie L. Schweiker, Hui-Qiang Q. Zhou, Frank Preugschat, Joyce A. Boucheron, Stephen A. Thomson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:2121-2125
A series of [1-aryl-1H-pyrazolo[3,4-d]pyrimidin-4-yl]arylhydrazones were discovered as novel inhibitors glycogen synthase kinase-3 (GSK-3). Based on initial modeling a detailed SAR was constructed. Modification of the interior binding aryl ring (Ar1)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59f47b3b411aa3acd6c34644b7c51ebc
https://doi.org/10.1016/j.bmcl.2004.02.036
https://doi.org/10.1016/j.bmcl.2004.02.036
Autor:
Jayme Lyn Roark Wilson, Scott Howard Dickerson, Stephanie L. Schweiker, Dulce Garrido, Joyce A. Boucheron, Stephen A. Thomson, Tony Y. Wang, Andrew J. Peat
Publikováno v:
ChemInform. 35
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0576cb1728172822c15131ab4a8bc9da
https://doi.org/10.1002/chin.200435138
https://doi.org/10.1002/chin.200435138
Autor:
Claire Townsend, Andrew J. Peat, Stephen A. Thomson, Jayme Lyn Roark Wilson, Dulce Garrido, Christopher M. Terry, M. Craig McKay
Publikováno v:
Bioorganicmedicinal chemistry letters. 14(3)
This communication describes the discovery and synthesis of a series of 3-trifluoromethyl-4-nitro-5-arylpyrazoles as potent KATP channel agonists. The most potent compound reported is ca. 100-fold more potent than diazoxide and exhibits selectivity f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9da49513179d2073726d81bf069c28d1
https://pubmed.ncbi.nlm.nih.gov/14741296
https://pubmed.ncbi.nlm.nih.gov/14741296
Autor:
Scott Howard Dickerson, Stephanie L. Schweiker, Joyce A. Boucheron, Stephen A. Thomson, Jayme Lyn Roark Wilson, Tony Y. Wang, Andrew J. Peat, Dulce Garrido
Publikováno v:
Bioorganicmedicinal chemistry letters. 14(9)
A novel series of [1-(1H-benzimidazol-7-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl] arylhydrazones was synthesized and shown to potently inhibit glycogen synthase kinase-3 (GSK-3). In light of detailed structure-activity relationships and structural knowle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de09ee1e340334adf8e66f3e63001650
https://pubmed.ncbi.nlm.nih.gov/15080993
https://pubmed.ncbi.nlm.nih.gov/15080993