Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Jayesh S. Salvi"'
Autor:
Alex Colville, Jie-Yu Liu, Samantha Thomas, Heather D. Ishak, Ronghao Zhou, Julian D.D. Klein, David W. Morgens, Armon Goshayeshi, Jayesh S. Salvi, David Yao, Kaitlyn Spees, Michael C. Bassik, Thomas A. Rando
SUMMARYSelectively ablating senescent cells (“senolysis”) is an evolving therapeutic approach for age-related diseases. Current senolytics are limited to local administration by potency and side effects. While genetic screens could identify senol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a88afed6336669d0b2e87df9cf0658cd
https://doi.org/10.1101/2022.04.01.486768
https://doi.org/10.1101/2022.04.01.486768
Autor:
Brandon Ho, Grant W. Brown, Samuel A. Killackey, Ru Guo, Janet N.Y. Chan, Karim Mekhail, Nancy X. Liu, Elva Vidya, Amanda C. Hall, Jeffrey E. Lee, Jayesh S. Salvi, Karan J. Abraham
Publikováno v:
Nucleic Acids Research
Dietary calorie restriction is a broadly acting intervention that extends the lifespan of various organisms from yeast to mammals. On another front, magnesium (Mg2+) is an essential biological metal critical to fundamental cellular processes and is c
Autor:
Karim Mekhail, Jayesh S. Salvi
Publikováno v:
Nucleus
Amyotrophic lateral sclerosis (ALS) is a severely debilitating neurodegenerative disease linked to mutations in various genes implicated in cytoplasmic RNA metabolism. Recent studies from genetic models have also helped reveal connections between var
Autor:
Cindy T. J. van Velthoven, Antoine de Morrée, Qiang Gan, Thomas A. Rando, Igor Akimenko, Stefano Biressi, Marco Quarta, Jayesh S. Salvi, Julian D. D. Klein
Publikováno v:
Proceedings of the National Academy of Sciences. 114
Tissue regeneration depends on the timely activation of adult stem cells. In skeletal muscle, the adult stem cells maintain a quiescent state and proliferate upon injury. We show that muscle stem cells (MuSCs) use direct translational repression to m
Autor:
Betty P.K. Poon, Tony Liu, Andrew Emili, Jonathan B. Olsen, Jayesh S. Salvi, Nurussaba Khanam, Janet N.Y. Chan, Kirk Szafranski, Jane D. Wu, Karim Mekhail
Publikováno v:
Developmental Cell. 30(2):177-191
Summary Intergenic transcription within repetitive loci such as the ribosomal DNA (rDNA) repeats of yeast commonly triggers aberrant recombination. Major mechanisms suppressing aberrant rDNA recombination rely on chromatin silencing or RNAPII repress
Publikováno v:
Aging Cell. 12:67-75
Telomere dysfunction is linked with genome instability and premature aging. Roles for sirtuin proteins at telomeres are thought to promote lifespan in yeast and mammals. However, replicative lifespan of the budding yeast Saccharomyces cerevisiae shor
Autor:
Betty P.K. Poon, Jonathan B. Olsen, Andrew Emili, Jayesh S. Salvi, Karim Mekhail, Janet N.Y. Chan
Publikováno v:
Developmental cell. 20(6)
Heterochromatin, or silent chromatin, preferentially resides at the nuclear envelope. Telomeres and rDNA repeats are the two major perinuclear silent chromatin domains of Saccharomyces cerevisiae. The Cohibin protein complex maintains rDNA repeat sta