From structure to clinic: Design of a muscarinic M1 receptor agonist with potential to treatment of Alzheimer's disease

Autor: Alastair J H, Brown, Sophie J, Bradley, Fiona H, Marshall, Giles A, Brown, Kirstie A, Bennett, Jason, Brown, Julie E, Cansfield, David M, Cross, Chris, de Graaf, Brian D, Hudson, Louis, Dwomoh, João M, Dias, James C, Errey, Edward, Hurrell, Jan, Liptrot, Giulio, Mattedi, Colin, Molloy, Pradeep J, Nathan, Krzysztof, Okrasa, Greg, Osborne, Jayesh C, Patel, Mark, Pickworth, Nathan, Robertson, Shahram, Shahabi, Christoffer, Bundgaard, Keith, Phillips, Lisa M, Broad, Anushka V, Goonawardena, Stephen R, Morairty, Michael, Browning, Francesca, Perini, Gerard R, Dawson, John F W, Deakin, Robert T, Smith, Patrick M, Sexton, Julie, Warneck, Mary, Vinson, Tim, Tasker, Benjamin G, Tehan, Barry, Teobald, Arthur, Christopoulos, Christopher J, Langmead, Ali, Jazayeri, Robert M, Cooke, Prakash, Rucktooa, Miles S, Congreve, Malcolm, Weir, Andrew B, Tobin

Publikováno v: Trends Pharmacol Sci

Current therapies for Alzheimer's disease seek to correct for defective cholinergic transmission by preventing the breakdown of acetylcholine through inhibition of acetylcholinesterase, these however have limited clinical efficacy. An alternative app

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7763e10dd2dc92975133618856c2920a
https://pubmed.ncbi.nlm.nih.gov/35101279

Comparison of Orexin 1 and Orexin 2 Ligand Binding Modes Using X-ray Crystallography and Computational Analysis

Autor: Mathieu Rappas, Ammar A. E. Ali, Kirstie A. Bennett, Jason D. Brown, Sarah J. Bucknell, Miles Congreve, Robert M. Cooke, Gabriella Cseke, Chris de Graaf, Andrew S. Doré, James C. Errey, Ali Jazayeri, Fiona H. Marshall, Jonathan S. Mason, Richard Mould, Jayesh C. Patel, Benjamin G. Tehan, Malcolm Weir, John A. Christopher

[Image: see text] The orexin system, which consists of the two G protein-coupled receptors OX(1) and OX(2), activated by the neuropeptides OX-A and OX-B, is firmly established as a key regulator of behavioral arousal, sleep, and wakefulness and has b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee0d1e9cf558d3f2bc1e5e706f4b6a9b
https://europepmc.org/articles/PMC7050010/

Two distinct cytoplasmic regions of the beta2 integrin chain regulate RhoA function during phagocytosis

Autor: Agnès Wiedemann, Andy Tsun, Jenson Lim, Jayesh C Patel, Yvette van Kooyk, Emmanuelle Caron

Publikováno v: The Journal of Cell Biology
Journal of Cell Biology, 172(7), 1069-79. Rockefeller University Press
Journal of Cell Biology
Journal of Cell Biology, Rockefeller University Press, 2006, 172 (7), pp.1069-1079. ⟨10.1083/jcb.200508075⟩
Wiedemann, A, Patel, J C, Lim, J, Tsun, A, van Kooyk, Y & Caron, E 2006, ' Two distinct cytoplasmic regions of the beta2 integrin chain regulate RhoA function during phagocytosis ', Journal of Cell Biology, vol. 172, no. 7, pp. 1069-79 . https://doi.org/10.1083/jcb.200508075

AlphaMbeta2 integrins mediate phagocytosis of opsonized particles in a process controlled by RhoA, Rho kinase, myosin II, Arp2/3, and actin polymerization. AlphaMbeta2, Rho, Arp2/3, and F-actin accumulate underneath bound particles; however, the mech

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b67695d3647b7125ee2fb5465132d38d
https://doi.org/10.1083/jcb.200508075

Rheological Characterization of Body Lotions

Autor: Ming Long Yao, Jayesh C. Patel

Publikováno v: Applied Rheology, Vol 11, Iss 2, Pp 83-88 (2001)

This study is attempted to demonstrate the application of rheological measurements in characterization of cosmetics products. As part of this study, several rheological tests were carried out on three common, commercially available body lotions to an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::118daa512d4655e1dba32ab71645e864
https://doaj.org/article/3b0f58e52dd2499ca76d2e7b0ab5f3a5

Vav regulates activation of Rac but not Cdc42 during FcgammaR-mediated phagocytosis

Autor: Emmanuelle Caron, Jayesh C. Patel, Alan Hall

Publikováno v: Molecular biology of the cell. 13(4)

Phagocytosis is the process whereby cells direct the spatially localized, receptor-driven engulfment of particulate materials. It proceeds via remodeling of the actin cytoskeleton and shares many of the core cytoskeletal components involved in adhesi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54dee4b393f984f13405fb1075c8ac0a
https://pubmed.ncbi.nlm.nih.gov/11950933