Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Jayesh A. Kulkarni"'
Autor:
Kevin An, Daniel Kurek, Mark Mahadeo, Yao Zhang, Jenifer L. Thewalt, Pieter R. Cullis, Jayesh A. Kulkarni
Publikováno v:
Langmuir. 38:14036-14043
Nucleic acid therapeutics represent a major advance toward treating diseases at their root cause. However, nucleic acids are prone to degradation by serum endonucleases, clearance through the immune system, and rapid degradation in complex medium. To
Autor:
Miffy Hok Yan Cheng, Jerry Leung, Yao Zhang, Colton Strong, Genc Basha, Arash Momeni, Yihang Chen, Eric Jan, Amir Abdolahzadeh, Xinying Wang, Jayesh A. Kulkarni, Dominik Witzigmann, Pieter R. Cullis
Publikováno v:
Advanced Materials.
Autor:
Adam M, Crowe, Jessica M C, Krekhno, Kirstin L, Brown, Jayesh A, Kulkarni, Katherine C, Yam, Lindsay D, Eltis
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(40)
Autor:
Ling Vicky Li, Dominik Witzigmann, Gurpreet K. Singhera, Chen X. Yang, Tillie-Louise Hackett, James C. Hogg, Pascal Leclair, Jayesh A. Kulkarni, Pieter R. Cullis, Xuan Li, Delbert R. Dorscheid, Don D. Sin, Chinten James Lim, Anthony Tam
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 321:L377-L391
Genome-wide association studies have shown that a gene variant in the Family with sequence similarity 13, member A (FAM13A) is strongly associated with reduced lung function and the appearance of respiratory symptoms in patients with chronic obstruct
Autor:
Adam M. Crowe, Jessica M. C. Krekhno, Kirstin L. Brown, Jayesh A. Kulkarni, Katherine C. Yam, Lindsay D. Eltis
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Mycobacterium abscessus , an opportunistic pathogen responsible for pulmonary infections, contains genes predicted to encode two steroid catabolic pathways: a cholesterol catabolic pathway similar to that of Mycobacterium tuberculosis and a 4-androst
Autor:
Blair R. Leavitt, Roy van der Meel, Sam Chen, Sarah B. Thomson, Dominik Witzigmann, Pieter R. Cullis, Jayesh A. Kulkarni
Publikováno v:
Nature Nanotechnology. 16:630-643
The increasing number of approved nucleic acid therapeutics demonstrates the potential to treat diseases by targeting their genetic blueprints in vivo. Conventional treatments generally induce therapeutic effects that are transient because they targe
Publikováno v:
Langmuir : the ACS journal of surfaces and colloids. 38(25)
Hybrid lipid nanoparticles containing gold nanoparticles (LNP-GNPs) and drugs have potential for imaging applications as well as triggered release of LNP contents in response to pulsed laser or X-ray radiation mediated by the GNPs. However, methods t
Autor:
Camilla Hald Albertsen, Jayesh A. Kulkarni, Dominik Witzigmann, Marianne Lind, Karsten Petersson, Jens B. Simonsen
Publikováno v:
Advanced drug delivery reviews. 188
Lipid nanoparticles (LNPs) play an important role in mRNA vaccines against COVID-19. In addition, many preclinical and clinical studies, including the siRNA-LNP product, Onpattro®, highlight that LNPs unlock the potential of nucleic acid-based thera
Autor:
Sarah B. Thomson, Josh Zaifman, Blair R. Leavitt, Terri L. Petkau, Jayesh A. Kulkarni, Pieter R. Cullis, Austin Hill, Jerry Leung, Yuen Yi C. Tam, Pamela K. Wagner
Publikováno v:
Nanoscale
Lipid nanoparticle (LNP) formulations of nucleic acid are leading vaccine candidates for COVID-19, and enabled the first approved RNAi therapeutic, Onpattro. LNPs are composed of ionizable cationic lipids, phosphatidylcholine, cholesterol, and polyet
Autor:
Jerry Leung, Jayesh A. Kulkarni, Roy van der Meel, Sam Chen, Pieter R. Cullis, Dominik Witzigmann
Publikováno v:
Advanced Drug Delivery Reviews
Hereditary genetic disorders, cancer, and infectious diseases of the liver affect millions of people around the globe and are a major public health burden. Most contemporary treatments offer limited relief as they generally aim to alleviate disease s