The solution structure of the unbound IgG Fc receptor CD64 resembles its crystal structure: Implications for function.

Autor: Gar Kay Hui, Xin Gao, Jayesh Gor, Jinghua Lu, Peter D Sun, Stephen J Perkins

Publikováno v: PLoS ONE, Vol 18, Iss 9, p e0288351 (2023)

FcγRI (CD64) is the only high-affinity Fcγ receptor found on monocytes, macrophages, eosinophils, neutrophils and dendritic cells. It binds immunoglobulin G (IgG) antibody-antigen complexes at its Fc region to trigger key immune responses. CD64 con

Externí odkaz: https://doaj.org/article/65d310ba5b09425aaaaecc45d7472c60

Identification of diverse lipid‐binding modes in the groove of zinc α 2 glycoprotein reveals its functional versatility

Autor: Stephen J. Perkins, Sharon M. Kelly, Jayesh Gor, Lindsay C. McDermott, Henna Zahid, Kersti Karu, Andy M. Lau

Publikováno v: The FEBS Journal. 289:1876-1896

ZAG is a multifunctional glycoprotein with a class I MHC-like protein fold and an α1-α2 lipid-binding groove. The intrinsic ZAG ligand is unknown. Our previous studies showed that ZAG binds the dansylated C11 fatty acid, DAUDA, differently to the b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::24e7b864399385d3fea0833e76e3dd9a
https://doi.org/10.1111/febs.16293

The solution structure of the complement deregulator FHR5 reveals a compact dimer and provides new insights into CFHR5 nephropathy

Autor: Lindsay C. McDermott, Jayesh S. Bhatt, Daniel P. Gale, Stephen J. Perkins, Jayesh Gor, Nilufar Kadkhodayi-Kholghi

Publikováno v: 'Journal of Biological Chemistry ', vol: 295, pages: 16342-16358 (2020)
J Biol Chem

The human complement Factor H–related 5 protein (FHR5) antagonizes the main circulating complement regulator Factor H, resulting in the deregulation of complement activation. FHR5 normally contains nine short complement regulator (SCR) domains, but

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec81c2660e4cdbc1212aa34b130fdd19
https://doi.org/10.1074/jbc.ra120.015132

Author response for 'Identification of diverse lipid‐binding modes in the groove of zinc α 2 glycoprotein reveals its functional versatility'

Autor: Jayesh Gor, Stephen J. Perkins, Lindsay C. McDermott, Sharon M. Kelly, Henna Zahid, Andy M. Lau, Kersti Karu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5ed4e5c3bef611aa4949814ccb6c5d3b
https://doi.org/10.1111/febs.16293/v2/response1

A multilaboratory comparison of calibration accuracy and the performance of external references in analytical ultracentrifugation.

Autor: Huaying Zhao, Rodolfo Ghirlando, Carlos Alfonso, Fumio Arisaka, Ilan Attali, David L Bain, Marina M Bakhtina, Donald F Becker, Gregory J Bedwell, Ahmet Bekdemir, Tabot M D Besong, Catherine Birck, Chad A Brautigam, William Brennerman, Olwyn Byron, Agnieszka Bzowska, Jonathan B Chaires, Catherine T Chaton, Helmut Cölfen, Keith D Connaghan, Kimberly A Crowley, Ute Curth, Tina Daviter, William L Dean, Ana I Díez, Christine Ebel, Debra M Eckert, Leslie E Eisele, Edward Eisenstein, Patrick England, Carlos Escalante, Jeffrey A Fagan, Robert Fairman, Ron M Finn, Wolfgang Fischle, José García de la Torre, Jayesh Gor, Henning Gustafsson, Damien Hall, Stephen E Harding, José G Hernández Cifre, Andrew B Herr, Elizabeth E Howell, Richard S Isaac, Shu-Chuan Jao, Davis Jose, Soon-Jong Kim, Bashkim Kokona, Jack A Kornblatt, Dalibor Kosek, Elena Krayukhina, Daniel Krzizike, Eric A Kusznir, Hyewon Kwon, Adam Larson, Thomas M Laue, Aline Le Roy, Andrew P Leech, Hauke Lilie, Karolin Luger, Juan R Luque-Ortega, Jia Ma, Carrie A May, Ernest L Maynard, Anna Modrak-Wojcik, Yee-Foong Mok, Norbert Mücke, Luitgard Nagel-Steger, Geeta J Narlikar, Masanori Noda, Amanda Nourse, Tomas Obsil, Chad K Park, Jin-Ku Park, Peter D Pawelek, Erby E Perdue, Stephen J Perkins, Matthew A Perugini, Craig L Peterson, Martin G Peverelli, Grzegorz Piszczek, Gali Prag, Peter E Prevelige, Bertrand D E Raynal, Lenka Rezabkova, Klaus Richter, Alison E Ringel, Rose Rosenberg, Arthur J Rowe, Arne C Rufer, David J Scott, Javier G Seravalli, Alexandra S Solovyova, Renjie Song, David Staunton, Caitlin Stoddard, Katherine Stott, Holger M Strauss, Werner W Streicher, John P Sumida, Sarah G Swygert, Roman H Szczepanowski, Ingrid Tessmer, Ronald T Toth, Ashutosh Tripathy, Susumu Uchiyama, Stephan F W Uebel, Satoru Unzai, Anna Vitlin Gruber, Peter H von Hippel, Christine Wandrey, Szu-Huan Wang, Steven E Weitzel, Beata Wielgus-Kutrowska, Cynthia Wolberger, Martin Wolff, Edward Wright, Yu-Sung Wu, Jacinta M Wubben, Peter Schuck

Publikováno v: PLoS ONE, Vol 10, Iss 5, p e0126420 (2015)

Analytical ultracentrifugation (AUC) is a first principles based method to determine absolute sedimentation coefficients and buoyant molar masses of macromolecules and their complexes, reporting on their size and shape in free solution. The purpose o

Externí odkaz: https://doaj.org/article/3bd91e8f42734f39965350067490e003