Výsledky vyhledávání - "Jaydev N. Dholakia"

The Crystal Structure of Aminoglycoside-3′-Phosphotransferase-IIa, an Enzyme Responsible for Antibiotic Resistance

Autor: Taru Deva, Steven C. Shewry, Clyde A. Smith, Scott A. Brown, Roy L. Fuchs, Jaydev N. Dholakia, Didier Nurizzo, Michael H. Perlin, Edward N. Baker

Publikováno v: Journal of Molecular Biology. 327:491-506

A major factor in the emergence of antibiotic resistance is the existence of enzymes that chemically modify common antibiotics. The genes for these enzymes are commonly carried on mobile genetic elements, facilitating their spread. One such class of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0ef0e79172fd004c385de03ecd56499
https://doi.org/10.1016/s0022-2836(03)00121-9

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The signal cascade for the activation of protein synthesis during the maturation of starfish oocytes: a role for protein kinase C and homologies with maturation inXenopusand mammatian oocytes

Autor: Zhe Xu, Jaydev N. Dholakia, Merrill B. Hille

Publikováno v: Invertebrate Reproduction & Development. 30:81-97

Summary The goal of a growing oocyte is to prepare the female gamete for the rapid cleavages that follow fertilization. The oocyte stores proteins and mRNAs required for meiosis and mitosis, since little or no transcription of new mRNAs occurs during

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3a744e57da292be66463949ce3d92bbe
https://doi.org/10.1080/07924259.1996.9672534

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Purification and characterization of sea urchin initiation factor 2. The requirement of guanine nucleotide exchange factor for the release of eukaryotic polypeptide chain initiation factor 2-bound GDP

Autor: Zhe Xu, M. B. Hille, Jaydev N. Dholakia, Albert J. Wahba

Publikováno v: Journal of Biological Chemistry. 265:19319-19323

Protein synthesis in sea urchin eggs is stimulated dramatically upon fertilization. We previously demonstrated that this stimulation is primarily due to an increase in the rate of polypeptide chain initiation which in turn may be regulated at the lev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d0ff46196fa16fa11aba4e5c9842db89
https://doi.org/10.1016/s0021-9258(17)30660-9

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Developing a snapshot of the ATP binding domain(s) of aminoglycoside phosphotransferases

Autor: Scott A. Brown, Jaydev N. Dholakia, Michael H. Perlin

Publikováno v: Frontiers in bioscience : a journal and virtual library. 4

The aminoglycoside (AG) 3'-phosphotransferases [APH(3')s] are an important class of modifying enzymes which confer high-level resistance to those AGs actively modified by the enzymes. They catalyze the transfer of the terminal phosphate from ATP to t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03701dfc07c20751970535e0cf990bcf
https://pubmed.ncbi.nlm.nih.gov/9872732

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Activation of the double-stranded RNA-regulated protein kinase by depletion of endoplasmic reticular calcium stores

Autor: Jaydev N. Dholakia, Charles O. Brostrom, C. Robert Prostko, Margaret A. Brostrom

Publikováno v: The Journal of biological chemistry. 270(11)

Perturbants of the endoplasmic reticulum (ER), including Ca(2+)-mobilizing agents, provoke a rapid suppression of translational initiation in conjunction with an increased phosphorylation of the alpha-subunit of eukaryotic initiation factor (eIF)-2.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d014c1994a32e803b164f0c7af4ca1ea
https://pubmed.ncbi.nlm.nih.gov/7890757

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The translation efficiency of ovalbumin mRNA is determined in part by a 5'-end hairpin structure

Autor: Jaydev N. Dholakia, S.A. Theus, A.S. Watson, A.J. Wahba, C.D. Liarakos

Publikováno v: Archives of biochemistry and biophysics. 315(1)

We have investigated the role in translation of the secondary structure in the noncoding leader (NCL) sequence of ovalbumin mRNA. Deletion of a stem-loop structure from the mRNA 5′-end (hairpin-1) produced a 2.5-fold decrease in mRNA translation ra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75a1fcdb6f1da56158d00fd51cf60269
https://pubmed.ncbi.nlm.nih.gov/7979405

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Internal translation initiation on poliovirus RNA: further characterization of La function in poliovirus translation in vitro

Autor: Vadim I. Agol, Jaydev N. Dholakia, Han S. Lee, Daniel J. Kenan, Yuri V. Svitkin, Karen Meerovitch, Nahum Sonenberg

Initiation of poliovirus RNA translation by internal entry of ribosomes is believed to require the participation of trans-acting factors. The mechanism of action of these factors is poorly defined. The limiting amount of one of these factors, La prot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48df606938d75a4ac9f55d5f81526100
https://europepmc.org/articles/PMC236611/

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