Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Jaydeep K Srimani"'
Publikováno v:
Molecular Systems Biology, Vol 13, Iss 10, Pp 1-11 (2017)
Abstract The postantibiotic effect (PAE) refers to the temporary suppression of bacterial growth following transient antibiotic treatment. This effect has been observed for decades for a wide variety of antibiotics and microbial species. However, des
Externí odkaz:
https://doaj.org/article/c1513c283f0347f3b86bfcf1d1bba5fa
Autor:
Cheemeng Tan, Robert Phillip Smith, Jaydeep K Srimani, Katherine A Riccione, Sameer Prasada, Meta Kuehn, Lingchong You
Publikováno v:
Molecular Systems Biology, Vol 8, Iss 1, Pp 1-11 (2012)
Abstract The inoculum effect (IE) refers to the decreasing efficacy of an antibiotic with increasing bacterial density. It represents a unique strategy of antibiotic tolerance and it can complicate design of effective antibiotic treatment of bacteria
Externí odkaz:
https://doaj.org/article/c268af2f8d35496ba40f6810a5285906
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e105408 (2014)
Many cellular decision processes, including proliferation, differentiation, and phenotypic switching, are controlled by bistable signaling networks. In response to transient or intermediate input signals, these networks allocate a population fraction
Externí odkaz:
https://doaj.org/article/f042ad9e31774dcbb2e609868ed6bbf5
Autor:
Allison J. Lopatkin, Hannah R. Meredith, Jaydeep K. Srimani, Connor Pfeiffer, Rick Durrett, Lingchong You
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
It is unclear whether the transfer of plasmids carrying antibiotic resistance genes can explain their persistence when antibiotics are not present. Here, Lopatkin et al. show that conjugal plasmids, even when costly, are indeed transferred at suffici
Externí odkaz:
https://doaj.org/article/10bb373fb9b849cb90cc4010bf2d8a82
Publikováno v:
Clinical Pharmacology & Therapeutics.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f4f24163547629185a1e493b06c2d0b
https://doi.org/10.1002/cpt.2917
https://doi.org/10.1002/cpt.2917
Autor:
Sosana Delimpasi, Meletios A. Dimopoulos, Jan Straub, Argiris Symeonidis, Roman Hájek, Cyrille Touzeau, Viralkumar K. Bhanderi, Jesus Berdeja, Petr Pavlíček, Jeffrey V. Matous, Pawel J. Robak, Kaveri Suryanarayan, Miguel Villareal, Dasha Cherepanov, Jaydeep K. Srimani, Huilan Yao, Richard Labotka, Robert Z. Orlowski
Publikováno v:
Blood. 140:9995-9997
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::368da8e5a1eb1891530e35e672f38c44
https://doi.org/10.1182/blood-2022-163092
https://doi.org/10.1182/blood-2022-163092
Autor:
Jaydeep K. Srimani, Paul M. Diderichsen, Michael J. Hanley, Karthik Venkatakrishnan, Richard Labotka, Neeraj Gupta
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology. 11:1085-1099
Ixazomib is an oral proteasome inhibitor approved in combination with lenalidomide and dexamethasone for the treatment of relapsed/refractory multiple myeloma (MM). Approval in the United States, Europe, and additional countries was based on results
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::590e340cd40734451e4573cf7fc0fc6c
https://doi.org/10.1002/psp4.12815
https://doi.org/10.1002/psp4.12815
Autor:
Emily Symington, Glenn F. Pierce, Adam Giermasz, K. John Pasi, Stefan Tiefenbacher, Stephen J. Zoog, Mary Robinson, Savita Rangarajan, Steffen Rosen, Christian Vettermann, Donnie Mackenzie, Jaydeep K. Srimani, Benjamin Kim, Mei Huang, Terri Christianson
Publikováno v:
Blood. 136:2524-2534
Adeno-associated virus (AAV)-based gene therapies can restore endogenous factor VIII (FVIII) expression in hemophilia A (HA). AAV vectors typically use a B-domain–deleted FVIII transgene, such as human FVIII-SQ in valoctocogene roxaparvovec (AAV5-F
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7b54fc4a67379b3e101a905a194db2a
https://doi.org/10.1182/blood.2020005683
https://doi.org/10.1182/blood.2020005683
Autor:
Peng Dong, Manoj V. Maddali, Jaydeep K. Srimani, François Thélot, Joseph R. Nevins, Bernard Mathey-Prevot, Lingchong You
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-1 (2018)
This Article contains errors in Supplementary Table 3, which are described in the Author Correction associated with this Article. The simulation results in the Article were based on the correct formula and thus the results are not affected by this co
Externí odkaz:
https://doaj.org/article/0d5e531da28c419a879688a72d18d04b
Autor:
Lingchong You, Allison J. Lopatkin, Connor Pfeiffer, Hannah R. Meredith, Rick Durrett, Jaydeep K. Srimani
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Nature Communications
Nature Communications
In the absence of antibiotic-mediated selection, sensitive bacteria are expected to displace their resistant counterparts if resistance genes are costly. However, many resistance genes persist for long periods in the absence of antibiotics. Horizonta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab8c61561f362edda0e307f4269df3d0
https://doaj.org/article/10bb373fb9b849cb90cc4010bf2d8a82
https://doaj.org/article/10bb373fb9b849cb90cc4010bf2d8a82