Identification of intracellular cavin target proteins reveals cavin-PP1alpha interactions regulate apoptosis

Autor: Kerrie-Ann McMahon, Yeping Wu, Yann Gambin, Emma Sierecki, Vikas A. Tillu, Thomas Hall, Nick Martel, Satomi Okano, Shayli Varasteh Moradi, Jayde E. Ruelcke, Charles Ferguson, Alpha S. Yap, Kirill Alexandrov, Michelle M. Hill, Robert G. Parton

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)

Caveolae are plasma membrane invaginations containing cavin proteins that are disrupted upon stress stimuli, causing cavin release inside the cell. Here, McMahon et al. identify cavin interacting proteins using proteomic analyses and reveal functions

Externí odkaz: https://doaj.org/article/7e714ae10b044f39b3b19d07f1029486

Cavin-1/PTRF alters prostate cancer cell-derived extracellular vesicle content and internalization to attenuate extracellular vesicle-mediated osteoclastogenesis and osteoblast proliferation

Autor: Kerry L. Inder, Jayde E. Ruelcke, Lara Petelin, Hyeongsun Moon, Eunju Choi, James Rae, Antje Blumenthal, Dietmar Hutmacher, Nicholas A. Saunders, Jennifer L. Stow, Robert G. Parton, Michelle M. Hill

Publikováno v: Journal of Extracellular Vesicles, Vol 3, Iss 0, Pp 1-14 (2014)

Background: Tumour-derived extracellular vesicles (EVs) play a role in tumour progression; however, the spectrum of molecular mechanisms regulating EV secretion and cargo selection remain to be fully elucidated. We have reported that cavin-1 expressi

Externí odkaz: https://doaj.org/article/164358b6992a4288a8cbaf67ae06edd9

Caveolin‐1‐driven membrane remodelling regulates hnRNPK‐mediated exosomal microRNA sorting in cancer

Autor: Renee S. Richards, Shivangi Wani, Nicole Cloonan, Vandhana Bharti, Amanda Lewis, Carlos Salomon, Archa H. Fox, Aine Farrell, Jayde E. Ruelcke, Charles S. Bond, Robert G. Parton, David A. Margolin, Michelle M. Hill, Harley Robinson, Li Li, Alexandre S. Cristino, Andrew Lai, Robert A. Gardiner

Publikováno v: Clinical and Translational Medicine
Clinical and Translational Medicine, Vol 11, Iss 4, Pp n/a-n/a (2021)

Background Caveolae proteins play diverse roles in cancer development and progression. In prostate cancer, non‐caveolar caveolin‐1 (CAV1) promotes metastasis, while CAVIN1 attenuates CAV1‐induced metastasis. Here, we unveil a novel mechanism li

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57009289a83c453aa985bd2a2ce561db
http://europepmc.org/articles/PMC8031663

Medical students' perceptions and expectations regarding digital health education and training: A qualitative study

Autor: Mark G. Coulthard, Malshi Hathurusinghe, Anthony C Smith, Henry Lao, Jasmine Kirk, Madelaine-Marie Judd, Qichen Zhang, Nim Chi Yau, Sarah Jhetam, Nigel R Armfield, Sophie Gong, Buddhika Senanayake, Jayde E. Ruelcke, Sisira Edirippulige, Annalise Leikvold, Xiaoyun Zhou

Publikováno v: Journal of telemedicine and telecare. 28(4)

IntroductionDigital health – the convergence of digital technologies within health and health care to enhance the efficiency of health-care delivery – is fast becoming an integral part of routine medical practice. The integration of digital healt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61bf7468d2cd96b6d4588f42b30f6b7f
https://pubmed.ncbi.nlm.nih.gov/32571157

Iron Inhibits the Secretion of Apolipoprotein E in Cultured Human Adipocytes

Autor: Janske Reiling, Jingjing He, Jonathan P. Whitehead, V. Nathan Subramaniam, L. Jaskowski, Kim R. Bridle, N. Santrampurwala, Michelle M. Hill, Ahmed Mohamed, Darrell H. G. Crawford, Choaping Ng, Laurence J. Britton, Jayde E. Ruelcke

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology
Cellular and molecular gastroenterology and hepatology, 6(2), 215-217. Elsevier Inc.

Nonalcoholic steatohepatitis (NASH) is characterized by adipose tissue dysfunction with insulin resistance and the dysregulation of adipokines.1 Recent data indicate repartitioning of iron from the liver to adipocytes in obesity and a role for iron i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12f0da205f3275611d74375dbe138204
https://doi.org/10.1016/j.jcmgh.2018.04.005