Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Jayasimman Rajendran"'
Autor:
Nirajan Neupane, Jayasimman Rajendran, Jouni Kvist, Sandra Harjuhaahto, Bowen Hu, Veijo Kinnunen, Yang Yang, Anni I. Nieminen, Henna Tyynismaa
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)
Muscular pathologies, including muscular dystrophy, are caused by a number of cellular and metabolic perturbations; here, consequences of GRPEL1-null disrupted mitochondrial matrix protein import on muscle atrophy, metabolism, and stress responses ar
Externí odkaz:
https://doaj.org/article/121bc40521c0499bbf71f67b33e680f9
Autor:
Janne Purhonen, Vladislav Grigorjev, Robert Ekiert, Noora Aho, Jayasimman Rajendran, Rafał Pietras, Katarina Truvé, Mårten Wikström, Vivek Sharma, Artur Osyczka, Vineta Fellman, Jukka Kallijärvi
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
A difference in the survival of respiratory chain complex III deficient Bcs1l p.S78G mice was observed between two congenic mouse strains. Here the authors show how in one of the strains the combined effects of a spontaneously arising non-pathogenic
Externí odkaz:
https://doaj.org/article/3779b9d3fc13415ab6b4e35cb40df347
Autor:
Janne Purhonen, Jayasimman Rajendran, Matthias Mörgelin, Kristiina Uusi-Rauva, Shintaro Katayama, Kaarel Krjutskov, Elisabet Einarsdottir, Vidya Velagapudi, Juha Kere, Matti Jauhiainen, Vineta Fellman, Jukka Kallijärvi
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-16 (2017)
Abstract Mitochondrial disorders are among the most prevalent inborn errors of metabolism but largely lack treatments and have poor outcomes. High-fat, low-carbohydrate ketogenic diets (KDs) have shown beneficial effects in mouse models of mitochondr
Externí odkaz:
https://doaj.org/article/78dd4d8abb004a4485544bb1aa809497
Autor:
Jayasimman Rajendran, Janne Purhonen, Saara Tegelberg, Olli‐Pekka Smolander, Matthias Mörgelin, Jan Rozman, Valerie Gailus‐Durner, Helmut Fuchs, Martin Hrabe de Angelis, Petri Auvinen, Eero Mervaala, Howard T Jacobs, Marten Szibor, Vineta Fellman, Jukka Kallijärvi
Publikováno v:
EMBO Molecular Medicine, Vol 11, Iss 1, Pp n/a-n/a (2019)
Abstract Alternative oxidase (AOX) is a non‐mammalian enzyme that can bypass blockade of the complex III‐IV segment of the respiratory chain (RC). We crossed a Ciona intestinalis AOX transgene into RC complex III (cIII)‐deficient Bcs1lp.S78G kn
Externí odkaz:
https://doaj.org/article/4482183c413e432b817baa4364affa08
Autor:
Michael J Williams, Philip Goergen, Jayasimman Rajendran, Galina Zheleznyakova, Maria G Hägglund, Emelie Perland, Sonchita Bagchi, Argyro Kalogeropoulou, Zaid Khan, Robert Fredriksson, Helgi B Schiöth
Publikováno v:
PLoS Genetics, Vol 10, Iss 9, p e1004499 (2014)
In all animals managing the size of individual meals and frequency of feeding is crucial for metabolic homeostasis. In the current study we demonstrate that the noradrenalin analogue octopamine and the cholecystokinin (CCK) homologue Drosulfakinin (D
Externí odkaz:
https://doaj.org/article/74fc0e4875c54ec2bbc42e889480636e
Autor:
Jayasimman Rajendran, Nikica Tomašić, Heike Kotarsky, Eva Hansson, Vidya Velagapudi, Jukka Kallijärvi, Vineta Fellman
Publikováno v:
International Journal of Molecular Sciences, Vol 17, Iss 11, p 1824 (2016)
Mitochondrial disorders cause energy failure and metabolic derangements. Metabolome profiling in patients and animal models may identify affected metabolic pathways and reveal new biomarkers of disease progression. Using liver metabolomics we have sh
Externí odkaz:
https://doaj.org/article/93670aa2fa02499f83c11a0e072a2e41
Autor:
Noora Aho, Mårten Wikström, Vladislav Grigorjev, Vineta Fellman, Vivek Sharma, Janne Purhonen, Artur Osyczka, Robert Ekiert, Jukka Kallijärvi, Rafał Pietras, Katarina Truvé, Jayasimman Rajendran
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nature Communications
Nature Communications
We previously observed an unexpected fivefold (35 vs. 200 days) difference in the survival of respiratory chain complex III (CIII) deficient Bcs1lp.S78G mice between two congenic backgrounds. Here, we identify a spontaneous homoplasmic mtDNA variant
Autor:
Pooja Manjunath, Jouni Kvist, Sundar Baral, Reijo Käkelä, Jayasimman Rajendran, Rubén Torregrosa-Muñumer, Henna Tyynismaa, Yang Yang, Svetlana Konovalova, Xiaonan Liu, Minna Holopainen, Pentti Somerharju, Markku Varjosalo
Cardiolipin (CL) is an essential phospholipid for mitochondrial structure and function. Here we present a small mitochondrial protein, NERCLIN, as a negative regulator of CL homeostasis and mitochondrial ultrastructure. Primate-specific NERCLIN is ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5f76effa148a3c02833c3b6e140819b1
https://doi.org/10.1101/2021.01.03.424667
https://doi.org/10.1101/2021.01.03.424667
Autor:
Olli-Pekka Smolander, Saara Tegelberg, Vineta Fellman, Janne Purhonen, Jukka Kallijärvi, Jayasimman Rajendran, Eija Pirinen
Publikováno v:
The FASEB Journal. 32:5913-5926
Biosynthetic precursors of NAD+ can replenish a decreased cellular NAD+ pool and, supposedly via sirtuin (SIRT) deacetylases, improve mitochondrial function. We found decreased hepatic NAD+ concentration and downregulated biosynthesis in Bcs1lp.S78G
Autor:
Janne, Purhonen, Jayasimman, Rajendran, Saara, Tegelberg, Olli-Pekka, Smolander, Eija, Pirinen, Jukka, Kallijärvi, Vineta, Fellman
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
Biosynthetic precursors of NAD