Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Jayashree Karar"'
Autor:
Julie K. Jadlowsky, Rachel Leskowitz, Stephen McKenna, Jayashree Karar, Yujie Ma, Anlan Dai, Gabriela Plesa, Fang Chen, Kathleen Alexander, Jennifer Petrella, Nan Gong, Wei-Ting Hwang, Olivia Farrelly, Julie Barber-Rotenberg, Shannon Christensen, Vanessa E. Gonzalez, Anne Chew, Joseph A. Fraietta, Carl H. June
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 1, Pp 101186- (2024)
The use of lentiviral vectors in cell and gene therapy is steadily increasing, both in commercial and investigational therapies. Although existing data increasingly support the usefulness and safety of clinical-grade lentiviral vectors used in cell m
Externí odkaz:
https://doaj.org/article/7bc0c17d5d0e4617bc7ee7d437b08ef4
Autor:
Qing Yao, Li Zhang, Xiaobo Wan, Jing Chen, Liyan Hu, Xiaojun Ding, Lin Li, Jayashree Karar, Hongzhuang Peng, She Chen, Niu Huang, Frank J Rauscher, Feng Shao
Publikováno v:
PLoS Pathogens, Vol 10, Iss 11, p e1004522 (2014)
Enteropathogenic E. coli (EPEC) and related enterobacteria rely on a type III secretion system (T3SS) effector NleE to block host NF-κB signaling. NleE is a first in class, novel S-adenosyl-L-methionine (SAM)-dependent methyltransferase that methyla
Externí odkaz:
https://doaj.org/article/e9cac2a87f004eaa93eed6adfd1244c8
Autor:
Frank J. Rauscher, Joseph R. Testa, Mitchell Cheung, S. Bruce Malkowicz, Anne M. Bowcock, J. William Harbour, Li Cao, Kyewon Park, Jayashree Karar, Jeremy Prokop, Hongzhuang Peng
Introduced mutations in BAP1 that are predicted to disrupt the helix structure of the BAP1-ULD domain dramatically disassociate its binding to the ASXL2-AB box. The GST-UCH association assay was performed with highly purified recombinant ULD-WT, L-P,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ba88e5e8a1f4ff69ce800978db16f55
https://doi.org/10.1158/0008-5472.22418772
https://doi.org/10.1158/0008-5472.22418772
Autor:
Frank J. Rauscher, Joseph R. Testa, Mitchell Cheung, S. Bruce Malkowicz, Anne M. Bowcock, J. William Harbour, Li Cao, Kyewon Park, Jayashree Karar, Jeremy Prokop, Hongzhuang Peng
Deleterious mutations of the ubiquitin carboxy-terminal hydrolase BAP1 found in cancers are predicted to encode inactive truncated proteins, suggesting that loss of enzyme function is a primary tumorigenic mechanism. However, many tumors exhibit miss
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b82e0076b56ddeca5fddede56a40a7ce
https://doi.org/10.1158/0008-5472.c.6510222.v1
https://doi.org/10.1158/0008-5472.c.6510222.v1
Autor:
Frank J. Rauscher, Joseph R. Testa, Mitchell Cheung, S. Bruce Malkowicz, Anne M. Bowcock, J. William Harbour, Li Cao, Kyewon Park, Jayashree Karar, Jeremy Prokop, Hongzhuang Peng
The deletion R666-H669 in the ULD domain of BAP1 corresponding to that observed in a uveal melanoma completely abolished ASXL2 binding in vivo. HEK 293 cells were co-transiently transfected with plasmids expressing WT or mutant BAP1 and ASXL2 (261-64
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6d0c960a44a386f1dffa5a916266fef
https://doi.org/10.1158/0008-5472.22418778.v1
https://doi.org/10.1158/0008-5472.22418778.v1
Autor:
Frank J. Rauscher, Joseph R. Testa, Mitchell Cheung, S. Bruce Malkowicz, Anne M. Bowcock, J. William Harbour, Li Cao, Kyewon Park, Jayashree Karar, Jeremy Prokop, Hongzhuang Peng
Supplemental figure legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9c57e2eae84f7b6266ce085c76e9fc7
https://doi.org/10.1158/0008-5472.22418769
https://doi.org/10.1158/0008-5472.22418769
Autor:
Frank J. Rauscher, Katherine L.B. Borden, Shoukat Dedhar, Qihong Huang, Emmanuel Skordalakes, David W. Speicher, Alexandra S. Carolin, Christopher S. Paterno, Bruce Malkowicz, William Fredericks, Andrew J. Caton, Meenhard Herlyn, Torben Orntoft, Electron Kebebew, Mei He, Zhaoyuan Hou, Jayashree Karar, Paul C. McDonald, Jeremy W. Prokop, Michael J. Osborne, Mehdi Talebzadeh-Farrooji, Hongzhuang Peng
Total mRNA was extracted from cancer cell lines using RNeasy Mini Kit (Qiagen).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ade46a990104f62bb8b08043921e726
https://doi.org/10.1158/0008-5472.22401225
https://doi.org/10.1158/0008-5472.22401225
Autor:
Joseph R. Testa, Frank J. Rauscher, Jayashree Karar, Hongzhuang Peng, Samuel Litwin, Kathy Q. Cai, Craig W. Menges, Yinfei Tan, Eleonora Sementino, Jacqueline Talarchek, Jianming Pei, Mitchell Cheung, Yuwaraj Kadariya, Jinfei Xu
PDF file - 415K, Supplementary Figure 4. A and B, strong staining for the MM marker mesothelin seen in tumor tissues from both WT and Bap1+/- mice. C, Bap1 staining in MM tissue from WT mouse. MM, malignant mesothelioma; NI, normal intestinal mucosa,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d029cea4a1a0b92bbb7d97f708ff241
https://doi.org/10.1158/0008-5472.22403103.v1
https://doi.org/10.1158/0008-5472.22403103.v1
Autor:
Joseph R. Testa, Frank J. Rauscher, Jayashree Karar, Hongzhuang Peng, Samuel Litwin, Kathy Q. Cai, Craig W. Menges, Yinfei Tan, Eleonora Sementino, Jacqueline Talarchek, Jianming Pei, Mitchell Cheung, Yuwaraj Kadariya, Jinfei Xu
PDF file - 576K, Supplementary Figure 3. A, lower magnification view showing intestinal architecture of MM invasion into smooth muscle of intestinal wall. B, higher magnification view of invading tumor cells corresponding to area within rectangle in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29b26a620f1637b14ae7533e79d95662
https://doi.org/10.1158/0008-5472.22403106.v1
https://doi.org/10.1158/0008-5472.22403106.v1
Autor:
Frank J. Rauscher, Katherine L.B. Borden, Shoukat Dedhar, Qihong Huang, Emmanuel Skordalakes, David W. Speicher, Alexandra S. Carolin, Christopher S. Paterno, Bruce Malkowicz, William Fredericks, Andrew J. Caton, Meenhard Herlyn, Torben Orntoft, Electron Kebebew, Mei He, Zhaoyuan Hou, Jayashree Karar, Paul C. McDonald, Jeremy W. Prokop, Michael J. Osborne, Mehdi Talebzadeh-Farrooji, Hongzhuang Peng
Data collection and refinement statistics for the LIMD2 protein.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ec879013ecfb6420d949626ab145f75
https://doi.org/10.1158/0008-5472.22401207
https://doi.org/10.1158/0008-5472.22401207