Repression of Transcription by WT1-BASP1 Requires the Myristoylation of BASP1 and the PIP2-Dependent Recruitment of Histone Deacetylase

Autor: Eneda Toska, Hayley A. Campbell, Jayasha Shandilya, Sarah J. Goodfellow, Paul Shore, Kathryn F. Medler, Stefan G.E. Roberts

Publikováno v: Cell Reports, Vol 2, Iss 3, Pp 462-469 (2012)

The Wilms' tumor 1 protein WT1 is a transcriptional regulator that is involved in cell growth and differentiation. The transcriptional corepressor BASP1 interacts with WT1 and converts WT1 from a transcriptional activator to a repressor. Here, we dem

Externí odkaz: https://doaj.org/article/7066041f837e47c09aa6357aefe6cc56

Protein engineering and design in ion channels and receptors

Autor: Nadira, Khatoon, Sushanth, Adusumilli, Poulomi, Dey, Rachita, Sharma, Pradeepti, Kampani, Jayasha, Shandilya, Tapan K, Nayak

Publikováno v: Methods in cell biology. 169

Acetylcholine receptors (AChRs) expressed at the neuromuscular junction synapses are typical allosteric proteins that shuttle between at least two stable conformational states: Closed (C) and Open (O). Agonist binding to their target sites on the rec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::26ed406bc6c55e7add1c42ba454896bc
https://pubmed.ncbi.nlm.nih.gov/35623700

Efficiency measures the conversion of agonist binding energy into receptor conformational change

Autor: Jayasha Shandilya, Ridhima Vij, Anthony Auerbach, Tapan K. Nayak, Iva Bruhova

Publikováno v: The Journal of General Physiology

Receptors convert agonist-binding energy into conformational change. Nayak et al. describe a new agonist trait, efficiency, as the fraction of binding energy transformed into the mechanical work of conformational change and suggest that it is a gener

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc1d0dca0e37b4a71bad84f40d508c30
https://doi.org/10.1085/jgp.201812215

BASP1 interacts with oestrogen receptor α and modifies the tamoxifen response

Autor: Kathryn F. Medler, Andrew D. Davidson, Jayasha Shandilya, Samantha Carrera, Stefan G. E. Roberts, Lindsey A. Marsh, Kate J. Heesom

Publikováno v: Cell Death & Disease
Marsh, L, Carrera, S, Shandilya, J, Heesom, K, Davidson, A, Medler, K F & Roberts, S 2017, ' BASP1 interacts with estrogen receptor α and modifies the tamoxifen response ', Cell Death and Disease, vol. 8, no. 5, e2771 . https://doi.org/10.1038/cddis.2017.179

Tamoxifen binds to oestrogen receptor α (ERα) to elicit distinct responses that vary by cell/tissue type and status, but the factors that determine these differential effects are unknown. Here we report that the transcriptional corepressor BASP1 in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23a2f49ae7c405a4901624282114fc81
https://pubmed.ncbi.nlm.nih.gov/28492543

Characterization of nucleolin K88 acetylation defines a new pool of nucleolin colocalizing with pre-mRNA splicing factors

Autor: Jayasha Shandilya, Hélène Delage, Philippe Bouvet, Sanjeev Kumar, Benoit Moindrot, Karine Monier, Parijat Senapati, Sadhan Das, Tapas K. Kundu, Rong Cong, Fabien Mongelard

Publikováno v: FEBS Letters. 587:417-424

Nucleolin is a multifunctional protein that carries several post-translational modifications. We characterized nucleolin acetylation and developed antibodies specific to nucleolin K88 acetylation. Using this antibody we show that nucleolin is acetyla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c56e167a6bdfcaabcd9e4d769fc74c5
https://doi.org/10.1016/j.febslet.2013.01.035