Zobrazeno 1 - 10
of 118
pro vyhledávání: '"Jayaraman Seetharaman"'
Autor:
Efren Garcia-Maldonado, Andrew D. Huber, Sergio C. Chai, Stanley Nithianantham, Yongtao Li, Jing Wu, Shyaron Poudel, Darcie J. Miller, Jayaraman Seetharaman, Taosheng Chen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Nuclear receptors are ligand-activated transcription factors that can often be useful drug targets. Unfortunately, ligand promiscuity leads to two-thirds of receptors remaining clinically untargeted. PXR is a nuclear receptor that can be act
Externí odkaz:
https://doaj.org/article/c30e189d2e734c8aad1bc9b3e758e589
Autor:
Geetika Singh, Cristina D. Guibao, Jayaraman Seetharaman, Anup Aggarwal, Christy R. Grace, Dan E. McNamara, Sivaraja Vaithiyalingam, M. Brett Waddell, Tudor Moldoveanu
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
The authors show that the mechanism of BAK activation in mitochondrial apoptosis involves cooperation between direct activation by BH3-only protein BID and BAK autoactivation, providing a unifying basis for BAK triggering by BH3 ligands.
Externí odkaz:
https://doaj.org/article/948c7729db444ae0965cb207d8ea6853
Publikováno v:
Biology, Vol 11, Iss 11, p 1627 (2022)
The Rho protein, a homolog of Ras, is a member of the Ras superfamily of small GTPases. Rho family proteins are involved in cytoskeletal organization, cell mobility, and polarity, and are implicated in cancer morphogenesis. Although Rho homologs from
Externí odkaz:
https://doaj.org/article/fa2cbab5e11f416aa0a3e9c323b22adb
Autor:
Abhilash Padavannil, Chacko Jobichen, Yang Qinghua, Jayaraman Seetharaman, Adrian Velazquez-Campoy, Liu Yang, Shen Q Pan, J Sivaraman
Publikováno v:
PLoS Pathogens, Vol 10, Iss 3, p e1003948 (2014)
The Type IV Secretion System (T4SS) is the only bacterial secretion system known to translocate both DNA and protein substrates. The VirB/D4 system from Agrobacterium tumefaciens is a typical T4SS. It facilitates the bacteria to translocate the VirD2
Externí odkaz:
https://doaj.org/article/89f604c8daf04450a3427cd1621ef0f9
Autor:
Andrew E Bruno, Amanda M Ruby, Joseph R Luft, Thomas D Grant, Jayaraman Seetharaman, Gaetano T Montelione, John F Hunt, Edward H Snell
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e100782 (2014)
Many bioscience fields employ high-throughput methods to screen multiple biochemical conditions. The analysis of these becomes tedious without a degree of automation. Crystallization, a rate limiting step in biological X-ray crystallography, is one o
Externí odkaz:
https://doaj.org/article/dde777582b5349c8a764b52b92a6b7a4
Autor:
Shuang-yong Xu, Alexandre P Kuzin, Jayaraman Seetharaman, Alice Gutjahr, Siu-Hong Chan, Yang Chen, Rong Xiao, Thomas B Acton, Gaetano T Montelione, Liang Tong
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e72114 (2013)
The crystal structure of a putative HNH endonuclease, Gmet_0936 protein from Geobacter metallireducens GS-15, has been determined at 2.6 Å resolution using single-wavelength anomalous dispersion method. The structure contains a two-stranded anti-par
Externí odkaz:
https://doaj.org/article/635f297fe2ca4bb4ae1613b8a9560c15
Autor:
Andrew D. Huber, Wenwei Lin, Shyaron Poudel, Yongtao Li, Jayaraman Seetharaman, Darcie J. Miller, Taosheng Chen
Publikováno v:
ASPET 2023 Annual Meeting Abstract - Cellular and Molecular Pharmacology.
Autor:
Wenwei Lin, Andrew D. Huber, Shyaron Poudel, Yongtao Li, Jayaraman Seetharaman, Darcie J. Miller, Taosheng Chen
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Ligand-binding promiscuity in detoxification systems protects the body from toxicological harm but is a roadblock to drug development due to the difficulty in optimizing small molecules to both retain target potency and avoid metabolic events. Immens
Publikováno v:
Biology. 11(11)
The Rho protein, a homolog of Ras, is a member of the Ras superfamily of small GTPases. Rho family proteins are involved in cytoskeletal organization, cell mobility, and polarity, and are implicated in cancer morphogenesis. Although Rho homologs from
Autor:
Timothy R. Stachowski, Murugendra Vanarotti, Jayaraman Seetharaman, Karlo Lopez, Marcus Fischer
Publikováno v:
Angewandte Chemie. 134