Optimization of physicochemical properties of pyrrolidine GPR40 AgoPAMs results in a differentiated profile with improved pharmacokinetics and reduced off-target activities

Autor: Jurica, Elizabeth A., Wu, Ximao, Williams, Kristin N., Haque, Lauren E., Rampulla, Richard A., Mathur, Arvind, Zhou, Min, Cao, Gary, Cai, Hong, Wang, Tao, Liu, Heng, Xu, Carrie, Kunselman, Lori K., Antrilli, Thomas M., Hicks, Michael B., Sun, Qin, Dierks, Elizabeth A., Apedo, Atsu, Moore, Douglas B., Foster, Kimberly A., Cvijic, Mary Ellen, Panemangalore, Reshma, Khandelwal, Purnima, Wilkes, Jason J., Zinker, Bradley A., Robertson, Donald G., Janovitz, Evan B., Galella, Michael, Li, Yi-Xin, Li, Julia, Ramar, Thangeswaran, Jalagam, Prasada Rao, Jayaram, Ramya, Whaley, Jean M., Barrish, Joel C., Robl, Jeffrey A., Ewing, William R., Ellsworth, Bruce A.

Publikováno v: In Bioorganic & Medicinal Chemistry 1 May 2023 85

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Discovery of Potent and Orally Bioavailable Dihydropyrazole GPR40 Agonists

Autor: Shi, Jun, Gu, Zhengxiang, Jurica, Elizabeth Anne, Wu, Ximao, Haque, Lauren E., Williams, Kristin N., Hernandez, Andres S., Hong, Zhenqiu, Gao, Qi, Dabros, Marta, Davulcu, Akin H., Mathur, Arvind, Rampulla, Richard A., Gupta, Arun Kumar, Jayaram, Ramya, Apedo, Atsu, Moore, Douglas B., Liu, Heng, Kunselman, Lori K., Brady, Edward J., Wilkes, Jason J., Zinker, Bradley A., Cai, Hong, Shu, Yue-Zhong, Sun, Qin, Dierks, Elizabeth A., Foster, Kimberly A., Xu, Carrie, Wang, Tao, Panemangalore, Reshma, Cvijic, Mary Ellen, Xie, Chunshan, Cao, Gary G., Zhou, Min, Krupinski, John, Whaley, Jean M., Robl, Jeffrey A., Ewing, William R., Ellsworth, Bruce Alan

Publikováno v: Journal of Medicinal Chemistry; 20240101, Issue: Preprints

Discovery of Potent and Orally Bioavailable Dihydropyrazole GPR40 Agonists.

Autor: Jun Shi, Zhengxiang Gu, Jurica, Elizabeth Anne, Ximao Wu, Haque, Lauren E., Williams, Kristin N., Hernandez, Andres S., Zhenqiu Hong, Qi Gao, Dabros, Marta, Davulcu, Akin H., Mathur, Arvind, Rampulla, Richard A., Gupta, Arun Kumar, Jayaram, Ramya, Apedo, Atsu, Moore, Douglas B., Heng Liu, Kunselman, Lori K., Brady, Edward J.

Publikováno v: Journal of Medicinal Chemistry; 2/8/2018, Vol. 61 Issue 3, p681-694, 14p

Heavy menstrual bleeding and dysmenorrhea are improved by Magnetic Resonance Guided Focused Ultrasound Surgery (MRgFUS) of adenomyosis.

Autor: Jayaram R; Department of Obstetrics and Gynecology, Womens Center, 146B Mettupalayam Road, Coimbatore, 641043 Tamil Nadu India.; Department of Radiology, Womens Center, 146B Mettupalayam Road, Coimbatore, 641043 Tamil Nadu India., Subbarayan K; Department of Radiology, Womens Center, 146B Mettupalayam Road, Coimbatore, 641043 Tamil Nadu India., Mithraprabhu S; Department of Obstetrics and Gynecology, Womens Center, 146B Mettupalayam Road, Coimbatore, 641043 Tamil Nadu India.; Australian Centre for Blood Diseases, Alfred Hospital/Monash University, Melbourne, Victoria 3800 Australia., Govindarajan M; Department of Obstetrics and Gynecology, Womens Center, 146B Mettupalayam Road, Coimbatore, 641043 Tamil Nadu India.; Department of Radiology, Womens Center, 146B Mettupalayam Road, Coimbatore, 641043 Tamil Nadu India.

Publikováno v: Fertility research and practice [Fertil Res Pract] 2016 May 16; Vol. 2, pp. 8. Date of Electronic Publication: 2016 May 16 (Print Publication: 2016).