Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Jayaprakash K. Nair"'
Autor:
Pachamuthu Kandasamy, Shohei Mori, Shigeo Matsuda, Namrata Erande, Dhrubajyoti Datta, Jennifer L. S. Willoughby, Nate Taneja, Jonathan O’Shea, Anna Bisbe, Rajar M. Manoharan, Kristina Yucius, Tuyen Nguyen, Ramesh Indrakanti, Swati Gupta, Jason A. Gilbert, Tim Racie, Amy Chan, Ju Liu, Renta Hutabarat, Jayaprakash K. Nair, Klaus Charisse, Martin A. Maier, Kallanthottathil G. Rajeev, Martin Egli, Muthiah Manoharan
Publikováno v:
Journal of Medicinal Chemistry. 66:2506-2523
Autor:
Krishna Aluri, Scott Waldron, Karyn Schmidt, Maja M. Janas, Elena Castellanos-Rizaldos, Xiumin Liu, Michael Arciprete, Diane Ramsden, Jing Li, Vasant Jadhav, Robin McDougall, Christopher R. Brown, Bahru A. Habtemariam, Dale C. Guenther, Gabriel J. Robbie, Saket Agarwal, Muthiah Manoharan, Akshay Vaishnaw, Ivan Zlatev, Jeffrey Kurz, Jayaprakash K. Nair, Martin Maier, Saeho Chong, Sagar Agarwal, Christopher S. Theile, Steven Liou, Muthusamy Jayaraman, Varun Goel, Kevin Fitzgerald, Christopher MacLauchlin, Klaus Charisse, Joseph A Cichocki, Ju Liu, Yuanxin Xu, Peter F Smith, Jing-Tao Wu, Xuemei Zhang, Yongli Gu
Publikováno v:
Drug Metabolism and Disposition. 50:781-797
Conjugation of oligonucleotide therapeutics, including small interfering ribonucleic acids (siRNAs) or antisense oligonucleotides (ASOs) to N-acetylgalactosamine (GalNAc) ligands has become the primary strategy for hepatocyte-targeted delivery, and w
Autor:
Justin B Lee, Kaixin Zhang, Yuen Yi C Tam, Joslyn Quick, Ying K Tam, Paulo JC Lin, Sam Chen, Yan Liu, Jayaprakash K Nair, Ivan Zlatev, Kallanthottathil G Rajeev, Muthiah Manoharan, Paul S Rennie, Pieter R Cullis
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 5, Iss C (2016)
The androgen receptor plays a critical role in the progression of prostate cancer. Here, we describe targeting the prostate-specific membrane antigen using a lipid nanoparticle formulation containing small interfering RNA designed to silence expressi
Externí odkaz:
https://doaj.org/article/6f4fc54f8a004c18b091a7dfbda75b0a
Autor:
Ryan Malone, Christopher S. Theile, Scott Lentini, Muthusamy Jayaraman, Mikyung Yu, Varun Goel, Rubina G. Parmar, Vasant Jadhav, Shigeo Matsuda, Mark K Schlegel, Guo He, Dennis Brown, June Qin, Swati Gupta, Timothy Racie, Svetlana Shulga-Morskaya, Anil V. Nair, Muthiah Manoharan, Jayaprakash K. Nair, Karyn Schmidt, Azar Shahraz, Ivan Zlatev, Christopher R. Brown, Martin Maier
Publikováno v:
Nucleic Acids Research
One hallmark of trivalent N-acetylgalactosamine (GalNAc)-conjugated siRNAs is the remarkable durability of silencing that can persist for months in preclinical species and humans. Here, we investigated the underlying biology supporting this extended
Autor:
Maja M. Janas, Saeho Chong, Mark K Schlegel, Jason Gilbert, Saket Agarwal, Vasant Jadhav, Dale Gunther, Michelle Jung, Mark Keating, Kelly Wassarman, Shigeo Matsuda, Arlin Rogers, Yongfeng Jiang, Lei Johnson, Elena Castellanos-Rizaldos, Jessica E. Sutherland, Scott Lentini, Urjana Poreci, Klaus Charisse, Jing Li, Anne Kasper, Yesseinia Anglero-Rodriguez, Jeff Rollins, Jing-Tao Wu, Alex Kelin, Sarah Le Blanc Sarah Le Blanc, Diana Cha, Martin E. Maier, Adam Castoreno, Samantha Chigas, Tuyen Nguyen, Muthiah Manoharan, Wendell P Davis, Haiyan Peng, Jayaprakash K. Nair, John Petrulis, Christopher S. Theile, Tyler Chickering, Ivan Zlatev, Tim Racie, Kirk Brown, Christopher R. Brown, Stuart Milstein, Jessica Bombardier, Melissa Mobley, Jeffrey Allen, Raj Maganti, Donald Foster, Kevin Fitzgerald, Jeffrey Kurz, Lauren Blair Woods, Robin McDougall
RNA interference (RNAi) therapeutics are a new class of medicines that can address unmet medical needs by silencing disease-causing gene transcripts. While delivery of short interfering RNAs (siRNAs) to hepatocytes has yielded multiple drug approvals
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b912cc876215cb4611322852009dc8f
https://doi.org/10.21203/rs.3.rs-946835/v1
https://doi.org/10.21203/rs.3.rs-946835/v1
Autor:
Kirk M. Brown, Jayaprakash K. Nair, Maja M. Janas, Yesseinia I. Anglero-Rodriguez, Lan T. H. Dang, Haiyan Peng, Christopher S. Theile, Elena Castellanos-Rizaldos, Christopher Brown, Donald Foster, Jeffrey Kurz, Jeffrey Allen, Rajanikanth Maganti, Jing Li, Shigeo Matsuda, Matthew Stricos, Tyler Chickering, Michelle Jung, Kelly Wassarman, Jeff Rollins, Lauren Woods, Alex Kelin, Dale C. Guenther, Melissa W. Mobley, John Petrulis, Robin McDougall, Timothy Racie, Jessica Bombardier, Diana Cha, Saket Agarwal, Lei Johnson, Yongfeng Jiang, Scott Lentini, Jason Gilbert, Tuyen Nguyen, Samantha Chigas, Sarah LeBlanc, Urjana Poreci, Anne Kasper, Arlin B. Rogers, Saeho Chong, Wendell Davis, Jessica E. Sutherland, Adam Castoreno, Stuart Milstein, Mark K. Schlegel, Ivan Zlatev, Klaus Charisse, Mark Keating, Muthiah Manoharan, Kevin Fitzgerald, Jing-Tao Wu, Martin A. Maier, Vasant Jadhav
Publikováno v:
Nature biotechnology. 40(10)
Therapeutics based on short interfering RNAs (siRNAs) delivered to hepatocytes have been approved, but new delivery solutions are needed to target additional organs. Here we show that conjugation of 2'-O-hexadecyl (C16) to siRNAs enables safe, potent
Autor:
Krishna Aluri, Laura Sepp-Lorenzino, Christopher R. Brown, Kevin Fitzgerald, Akin Akinc, Martin Maier, Lauren Blair, Peter F Smith, Ju Liu, Jing Li, Ramesh Indrakanti, Biplab Das, Xiumin Liu, Ivan Zlatev, Scott A Barros, Kallanthottathil G. Rajeev, Yongfeng Jiang, Saket Agarwal, Akshay Vaishnaw, Chris Tran, Klaus Charisse, Jingxuan Liu, Muthiah Manoharan, Shigeo Matsuda, Jayaprakash K. Nair, Jessica E. Sutherland, Tracy Zimmermann, Yuanxin Xu, Jing-Tao Wu, Wendell P Davis, Xuemei Zhang, Maja M. Janas, Vasant Jadhav, Mark K Schlegel
Publikováno v:
Nucleic Acids Research
For oligonucleotide therapeutics, chemical modifications of the sugar-phosphate backbone are frequently used to confer drug-like properties. Because 2′-deoxy-2′-fluoro (2′-F) nucleotides are not known to occur naturally, their safety profile wa
Autor:
Varun Kumar, June Qin, Yongfeng Jiang, Richard G Duncan, Benjamin Brigham, Shannon Fishman, Jayaprakash K Nair, Akin Akinc, Scott A Barros, Pia V Kasperkovitz
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 3, Iss C (2014)
Formulation of short interfering RNA (siRNA) into multicomponent lipid nanoparticles (LNP) is an effective strategy for hepatic delivery and therapeutic gene silencing. This study systematically evaluated the effect of polyethylene glycol (PEG) densi
Externí odkaz:
https://doaj.org/article/91eeff39ed3543dba1ef6fa9a40786ba
Autor:
Robin, McDougall, Diane, Ramsden, Sagar, Agarwal, Saket, Agarwal, Krishna, Aluri, Michael, Arciprete, Christopher, Brown, Elena, Castellanos-Rizaldos, Klaus, Charisse, Saeho, Chong, Joseph, Cichocki, Kevin, Fitzgerald, Varun, Goel, Yongli, Gu, Dale, Guenther, Bahru, Habtemariam, Vasant, Jadhav, Maja, Janas, Muthusamy, Jayaraman, Jeffrey, Kurz, Jing, Li, Ju, Liu, Xiumin, Liu, Steven, Liou, Chris, Maclauchlin, Martin, Maier, Muthiah, Manoharan, Jayaprakash K, Nair, Gabriel, Robbie, Karyn, Schmidt, Peter, Smith, Christopher, Theile, Akshay, Vaishnaw, Scott, Waldron, Yuanxin, Xu, Xuemei, Zhang, Ivan, Zlatev, Jing-Tao, Wu
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 50(6)
Conjugation of oligonucleotide therapeutics, including small interfering RNAs (siRNAs) or antisense oligonucleotides, to
Autor:
Alex R. Nanna, Kevin Fitzgerald, Zhi Xiang Voo, Martin Maier, Christoph Rader, Jayaprakash K. Nair, Ashish Garg, Christopher S. Theile, Justin M Pierson, Alexander V Kel'in
Publikováno v:
Nucleic Acids Research
Gene silencing by RNA interference (RNAi) has emerged as a powerful treatment strategy across a potentially broad range of diseases. Tailoring siRNAs to silence genes vital for cancer cell growth and function could be an effective treatment, but ther