Zobrazeno 1 - 10
of 3 185
pro vyhledávání: '"Jayapal"'
Autor:
Alexandria P. Eiken, Elizabeth Schmitz, Erin M. Drengler, Audrey L. Smith, Sydney A. Skupa, Kabhilan Mohan, Sandeep Rana, Sarbjit Singh, Jayapal Reddy Mallareddy, Grinu Mathew, Amarnath Natarajan, Dalia El-Gamal
Publikováno v:
Hemato, Vol 5, Iss 3, Pp 321-339 (2024)
Background: B-cell receptor (BCR) signaling is a central driver in chronic lymphocytic leukemia (CLL), along with the activation of pro-survival pathways (e.g., NF-κB) and aberrant anti-apoptotic mechanisms (e.g., BCL2) culminating to CLL cell survi
Externí odkaz:
https://doaj.org/article/d7db08149c6147c49528ecc49959d72e
Autor:
Nicholas J Mullen, Surendra K Shukla, Ravi Thakur, Sai Sundeep Kollala, Dezhen Wang, Nina Chaika, Juan F Santana, William R Miklavcic, Drew A LaBreck, Jayapal Reddy Mallareddy, David H Price, Amarnath Natarajan, Kamiya Mehla, David B Sykes, Michael A Hollingsworth, Pankaj K Singh
Publikováno v:
eLife, Vol 12 (2024)
Pyrimidine nucleotide biosynthesis is a druggable metabolic dependency of cancer cells, and chemotherapy agents targeting pyrimidine metabolism are the backbone of treatment for many cancers. Dihydroorotate dehydrogenase (DHODH) is an essential enzym
Externí odkaz:
https://doaj.org/article/3d1d4ecaa2d9414c902c7249254c6fee
Autor:
Sagnik Sen, Prithviraj Udaya, Jayapal Jeya Maheshwari, Piyush Kohli, Haemoglobin Parida, Naresh Babu Kannan, Kim Ramasamy, Kuppamuthu Dharmalingam
Publikováno v:
Indian Journal of Ophthalmology, Vol 71, Iss 8, Pp 3069-3079 (2023)
Purpose: To explore the vitreous humor proteome from type 2 diabetes subjects with proliferative diabetic retinopathy (PDR) in the Indian population. Methods: We performed mass spectrometry-based label-free quantitative analysis of vitreous proteome
Externí odkaz:
https://doaj.org/article/fd2e0dca6a124dd1960650f765a5c225
Autor:
Sagnik Sen, Prithviraj Udaya, Jayapal J Maheshwari, Kim Ramasamy, Naresh B Kannan, Kuppamuthu Dharmalingam
Publikováno v:
Indian Journal of Ophthalmology, Vol 71, Iss 5, Pp 2027-2040 (2023)
Purpose: To analyze and describe the proteome of the vitreous humour in eyes with idiopathic macular holes. Methods: We performed mass spectrometry (MS)-based label-free quantitative analysis of the vitreous proteome of idiopathic macular hole (IMH)
Externí odkaz:
https://doaj.org/article/3078a67f08304fa3b37762afc46d501a
Autor:
Jayapal Pandiaraja, Arumugam Shalini
Publikováno v:
APIK Journal of Internal Medicine, Vol 11, Iss 2, Pp 132-134 (2023)
Muscular tuberculosis is one of the rare types of tuberculosis, with an incidence of around 0.01%–1%. Muscular tuberculosis can be primary or secondary. Primary muscular tuberculosis can be due to direct trauma or direct inoculation of tuberculous
Externí odkaz:
https://doaj.org/article/84c686edb0534ce09dc084303f3524bd
Autor:
Kadarkarai Murugan, Chellasamy Panneerselvam, Jayapal Subramaniam, Manickam Paulpandi, Rajapandian Rajaganesh, Murugan Vasanthakumaran, Jagannathan Madhavan, S. Syed Shafi, Mathath Roni, Johan S. Portilla-Pulido, Stelia C. Mendez, Jonny E. Duque, Lan Wang, Al Thabiani Aziz, Balamurugan Chandramohan, Devakumar Dinesh, Shanmughavel Piramanayagam, Jiang-Shiou Hwang
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Mosquito borne diseases are on the rise because of their fast spread worldwide and the lack of effective treatments. Here we are focusing on the development of a novel anti-malarial and virucidal agent with biocidal effects also on its vecto
Externí odkaz:
https://doaj.org/article/1f9f52f69b8547088e1ac1803dfccff3
Autor:
Kadarkarai Murugan, Jayapal Subramaniam, Rajapandian Rajaganesh, Chellasamy Panneerselvam, Pandiyan Amuthavalli, Murugan Vasanthakumaran, Sudalaimani Jayashanthini, Devakumar Dinesh, Jaganathan Anitha, Lan Wang, Jiang-Shiou Hwang, Hans-Uwe Dahms, Sunaina Mudigonda, Al Thabiani Aziz
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Mosquitoes are a great menace for humankind since they transmit pathogenic organisms causing Malaria, Dengue, Chikungunya, Elephantiasis and Japanese encephalitis. There is an urgent need to discover new and novel biological tools to mitigat
Externí odkaz:
https://doaj.org/article/aeb0e786c0024b8aab6e4526a168e68b
Autor:
Manasi Venkat Koduvayur, Shrivarshini Vasudevan, Vikas Pandey, Jayapal Santhanakumar, Dilip Kumar Jha, Gopal Dharani
Publikováno v:
Frontiers in Marine Science, Vol 9 (2022)
Externí odkaz:
https://doaj.org/article/4977b5bbbe2840dfb88fd526c9d73929
Autor:
Pandiyan Amuthavalli, Jiang-Shiou Hwang, Hans-Uwe Dahms, Lan Wang, Jagannathan Anitha, Murugan Vasanthakumaran, Arumugam Dhanesh Gandhi, Kadarkarai Murugan, Jayapal Subramaniam, Manickam Paulpandi, Balamurugan Chandramohan, Shivangi Singh
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Microbes or parasites spread vector-borne diseases by mosquitoes without being affected themselves. Insecticides used in vector control produce a substantial problem for human health. This study synthesized zinc oxide nanoparticles (ZnO NPs)
Externí odkaz:
https://doaj.org/article/46311594992c41ad8770e7283312b783
Autor:
Alan Umfress, Sarbjit Singh, Kevin J. Ryan, Ayanabha Chakraborti, Florian Plattner, Yogesh Sonawane, Jayapal Reddy Mallareddy, Edward P. Acosta, Amarnath Natarajan, James A. Bibb
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Cyclin-dependent kinase 5 (Cdk5) is a crucial regulator of neuronal signal transduction. Cdk5 activity is implicated in various neuropsychiatric and neurodegenerative conditions such as stress, anxiety, depression, addiction, Alzheimer’s disease, a
Externí odkaz:
https://doaj.org/article/f4abb12095324eafaf3ed9bba08dbea1