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pro vyhledávání: '"Jayanthi Jayawardena"'
Autor:
Ya Hui Chiu, Alice Dautry-Varsat, Albert Bendelac, Daniel Lee, Jayanthi Jayawardena, Se Ho Park, Angela Weiss
Publikováno v:
The Journal of Experimental Medicine
Although recent studies have indicated that the major histocompatibility complex-like, beta2-microglobulin-associated CD1 molecules might function to present a novel chemical class of antigens, lipids and glycolipids, to alpha/beta T cells, little is
Publikováno v:
Seminars in Immunology. 10:391-398
In the past few years, several studies have unravelled a novel pathway of antigen presentation to T cells of the mammalian immune system. The antigens are presented by CD1, which appears to have evolved to present glycolipid antigens to alphabeta T c
Publikováno v:
Current opinion in immunology. 13(1)
Recently, different members of the CD1 family of MHC-like molecules have been shown to sample different intracellular compartments to present lipid and glycolipid antigens to T cells. Emerging models suggest that CD1 may have evolved to monitor the i
Publikováno v:
Immunity. (6):897-908
Endosomal trafficking is an essential component of the CD1 pathway of lipid antigen presentation to T cells. We demonstrate that CD1d access to endosomal compartments is under dual regulation by an intrinsic tyrosine-based motif, which governs intens