Alpha Lipoic Acid and Monoisoamyl-DMSA Combined Treatment Ameliorates Copper-Induced Neurobehavioral Deficits, Oxidative Stress, and Inflammation

Autor: Jayant Patwa, Ashima Thakur, Swaran Jeet Singh Flora

Publikováno v: Toxics, Vol 10, Iss 12, p 718 (2022)

Copper (Cu), being an essential trace metal, plays several roles in biological processes, though exposure to Cu can be potentially toxic to the brain and a few other soft organs. In the present study, we investigated the effects of the combined admin

Externí odkaz: https://doaj.org/article/e5b95d252d3d40f1946611a4ad756892

Synthesis, Molecular Docking, BSA, and In Vitro Reactivation Study of Imidazopyridine Oximes Against Paraoxon Inhibited Acetylcholinesterase

Autor: Ashima Thakur, Swaran J.S. Flora, Abha Sharma, Jayant Patwa

Publikováno v: Medicinal Chemistry. 18:273-287

Aim: To synthesize and evaluate the fused heterocyclic imidazopyridine oxime as a reactivator against paraoxon inhibited acetylcholinesterase. Background: Organophosphorus compounds (OPs) include parathion, malathion, chlorpyrifos, monocrotophos, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::91d7efe4741ff4374bd1fa7a7342d495
https://doi.org/10.2174/1573406417666210208223240

Monoisoamyl DMSA reduced copper-induced neurotoxicity by lowering 8-OHdG level, amyloid beta and Tau protein expressions in Sprague-Dawley rats

Autor: Swaran J.S. Flora, Jayant Patwa, Abha Sharma, Ashima Thakur

Publikováno v: Metallomics. 12:1428-1448

Introduction: copper dyshomeostasis has long been linked with several neurodegenerative disorders. The binding of Cu with amyloid beta and other neuronal proteins in the brain leads to the generation of oxidative stress, which eventually causes neuro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff7934418fb47b86ad2de0e23533b7a6
https://doi.org/10.1039/d0mt00083c

Contributors

Autor: Manoj Aggarwal, James Akingbasote, Arturo Anadón, Gregory J. Anger, Anthony E. Archibong, Irma Ares, Michael Aschner, Daiana S. Avila, Denise C. Bailey, Norman J. Barlow, Sudheer Beedanagari, P.P. Beltyukov, Karyn Bischoff, Carina Rodrigues Boeck, William M. Bracken, Emily Brehm, Richard M. Breyer, Susan Bright-Ponte, Mirjana Milosevic Brockett, Luisa Campagnolo, Edward W. Carney, Andrew Charrette, Sandrine Fleur Chebekoue, Catheryne Chiang, Wei-Chun Chou, Jane K. Cleal, Toby B. Cole, Daniel Cook, Robert W. Coppock, Lucio G. Costa, Margarita Curras-Collazo, Wanying Dai, Khoi Dao, Rosane Souza Da Silva, T. Zane Davis, Francisco Dominguez, Robin B. Doss, Margitta M. Dziwenka, Brian Enright, Carmen Estevan, Timothy J. Evans, Anna M. Fan, Marcelo Farina, Suzanne E. Fenton, Ayhan Filazi, Vanessa A. Fitsanakis, Rex FitzGerald, John Flaskos, Jodi A. Flaws, S.J.S. Flora, Vekataseshu K. Ganjam, Dale R. Gardner, Ramesh C. Garg, Jacqueline M. Garrick, Vincent F. Garry, Janee Gelineau-van Waes, Keith M. Godfrey, Yu V. Golubentseva, Roberto González-Martín, Benedict T. Green, Consuelo Guerri, Kavita Gulati, P.K. Gupta, Ramesh C. Gupta, Rekha K. Gupta, Najla Guthrie, Jeffery O. Hall, Alan J. Hargreaves, Kenneth J. Harris, Bridgett N. Hill, Corey J. Hilmas, Alan M. Hoberman, Karin S. Hougaard, Sinan Ince, Poorni R. Iyer, Nicklas R. Jacobsen, Starling Kalpana, Ramesh Kandimalla, Arthi Kanthasamy, Anumantha Kanthasamy, N.S. Khlebnikova, Nils Klüver, Prasada Rao S. Kodavanti, Kannan Krishnan, Shaila Kulkarni, Ozgur Kuzukiran, Rajiv Lall, Jessica Legradi, Rohan M. Lewis, Elise M. Lewis, Xin Li, Pinpin Lin, Bommanna G. Loganathan, Ivo F. Machado, Brinda Mahadevan, Susan L. Makris, Jitendra K. Malik, Ana Paula Marreilha dos Santos, Judit Marsillach, María Rosa Martínez-Larrañaga, María Aránzazu Martínez, Klara Matouskova, Roger O. McClellan, Dejan Milatovic, Ali Mustafa Mohammed, Thomas J. Montine, Peter Møller, Pushpinder Kaur Multani, Mingwei Ni, Efstathios Nikolaidis, Meliton N. Novilla, Stephanie Padilla, Carlos M. Palmeira, David Pamies, Manesh Kumar Panner Selvam, María Pascual, Jayant Patwa, Ashley Phillips, Micheline Piquette-Miller, V.B. Popov, M. Margaret Pratt, G.A. Protasova, Nishant Rai, João Ramalho-Santos, Aramandla Ramesh, Kausik Ray, Arunabha Ray, Aiguo Ren, Stephen J. Renaud, Drucilla J. Roberts, Lu Rongzhu, Magdalini Sachana, Heidi Sahlman, Nitin Saini, Vandna Saini, L.V. Shabasheva, Abha Sharma, Suresh C. Sikka, Marilyn Helen Silva, Ilker Simsek, Rajkumar Singh Kalra, Anita Sinha, Miguel A. Sogorb, Offie P. Soldin, Chunjuan Song, Ajay Srivastava, Szabina A. Stice, Tammy E. Stoker, Clinton A. Stonecipher, Sandra Szlapinski, Shihori Tanabe, Arun Tatiparthi, João Batista Teixeira da Rocha, Suresh Kumar Thokchom, Belen Tornesi, Vanda Torous, Peter Truran, Matthew C. Valdez, Laura N. Vandenberg, Neil Vargesson, Eugenio Vilanova, Kirsi H. Vähäkangas, Suryanarayana V. Vulimiri, Genoa R. Warner, Kevin D. Welch, Daniel C. Williams, Moges Woldemeskel, Jae-Ho Yang, Zhaobao Yin, Xiaoyou Ying, Begum Yurdakok-Dikmen, Snjezana Zaja-Milatovic, Changqing Zhou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a0dc2704509109027fc26dbd683a5376
https://doi.org/10.1016/b978-0-323-89773-0.01002-x

Oxidative/ Nitrosative Stress, 8-OHdG and MMP-9: The Possible Co-Links and Early Sign of Arsenic Induced Urinary Bladder Carcinogenesis in Experimental Rats

Autor: Swaran J.S. Flora, Kshirod Bihari Sathua, Jayant Patwa

Publikováno v: Free Radicals and Antioxidants. 9:22-28

Background: Presently arsenicosis is considered as dangerous health issues including cancer. Urinary bladder is one of the common target organs for developing carcinogenesis by arsenic exposure due to accumulation of arsenic toxic metabolites in blad

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::29cde320cd084ed8996c8bf63849efaa
https://doi.org/10.5530/fra.2019.1.5