Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Jayant Arora"'
Autor:
Aneesh Vijayan, Ronald Vogels, Rachel Groppo, Yi Jin, Selina Khan, Mirjam Van Kampen, Sytze Jorritsma, Satish Boedhoe, Miranda Baert, Harry van Diepen, Harmjan Kuipers, Jan Serroyen, Jorge Reyes- del Valle, Ann Broman, Lannie Nguyen, Sayoni Ray, Bader Jarai, Jayant Arora, Michelle Lifton, Benjamin Mildenberg, Georgeanna Morton, Sampa Santra, Tamar R. Grossman, Hanneke Schuitemaker, Jerome Custers, Roland Zahn
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Newly approved subunit and mRNA vaccines for respiratory syncytial virus (RSV) demonstrate effectiveness in preventing severe disease, with protection exceeding 80% primarily through the generation of antibodies. An alternative vaccine platf
Externí odkaz:
https://doaj.org/article/ad79a6b32f4f4a96b2a3d0c86c309c66
Publikováno v:
Journal of pharmaceutical sciences. 106(6)
Multidose formulations of biotherapeutics, which offer better dosage management and reduced production costs, require the addition of antimicrobial preservatives (APs). APs have been shown, however, to decrease protein stability in solution and cause
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83f5e5007fdb9dbb91026ae7a4d309fb
https://pubmed.ncbi.nlm.nih.gov/28212986
https://pubmed.ncbi.nlm.nih.gov/28212986
Autor:
Jayant Arora, Sangeeta B. Joshi, David D. Weis, Yue Hu, Hasige A. Sathish, C. Russell Middaugh, David B. Volkin, Steven M. Bishop, Reza Esfandiary
Publikováno v:
mAbs. 8(8)
Concentration-dependent reversible self-association (RSA) of monoclonal antibodies (mAbs) poses a challenge to their pharmaceutical development as viable candidates for subcutaneous delivery. While the role of the antigen-binding fragment (Fab) in in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73cc3f1d77baf4ab78c6ba87c3149579
https://pubmed.ncbi.nlm.nih.gov/27560842
https://pubmed.ncbi.nlm.nih.gov/27560842
Autor:
Ronald T. Toth, Christian Schöneich, Sangeeta B. Joshi, Olivier Mozziconacci, David B. Volkin, Jayant Arora, Shuxia Zhou
Publikováno v:
Molecular pharmaceutics. 13(4)
The metal-catalyzed oxidation by [Fe(II)(EDTA)](2-)/H2O2 of IgG-1 leads to the site-specific hydrolysis of peptide bonds in the Fc region. The major hydrolytic cleavage occurs between Met428 and His429, consistent with a mechanism reported for the si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee27e5ec5238b1aa716354a16aa0baef
https://pubmed.ncbi.nlm.nih.gov/26942274
https://pubmed.ncbi.nlm.nih.gov/26942274
Autor:
C. Russell Middaugh, David D. Weis, Jayant Arora, David B. Volkin, Ranajoy Majumdar, Steven M. Bishop, Hardeep S. Samra, John M. Hickey, Reza Esfandiary
Publikováno v:
mAbs
There is a need for new analytical approaches to better characterize the nature of the concentration-dependent, reversible self-association (RSA) of monoclonal antibodies (mAbs) directly, and with high resolution, when these proteins are formulated a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c52aad2d8d67ce6ce181771eb78d441f
https://pubmed.ncbi.nlm.nih.gov/25875351
https://pubmed.ncbi.nlm.nih.gov/25875351
Autor:
Jayant Arora
Publikováno v:
Archives of Orthopaedic and Trauma Surgery. 125:120-123
A patient with a transulnar styloid palmar scapho-lunate dislocation with median nerve injury is described. The dislocation could be reduced by closed manipulation under anaesthesia, and the scapho-lunate ligament was repaired subsequently using a My
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17ad27b474a212ae8f71840597ba3a21
https://doi.org/10.1007/s00402-004-0770-6
https://doi.org/10.1007/s00402-004-0770-6
Autor:
Anand Pillai, Jayant Arora
Publikováno v:
Injury Extra. 37:184-186
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8216c3934668a8b2974069641373529b
https://doi.org/10.1016/j.injury.2005.11.002
https://doi.org/10.1016/j.injury.2005.11.002
Autor:
David D. Weis, Ranajoy Majumdar, Jayant Arora, C. Russell Middaugh, David B. Volkin, Prakash Manikwar, John M. Hickey
Publikováno v:
Journal of the American Society for Mass Spectrometry. 23(12)
Chromatographic carry-over can severely distort measurements of amide H/D exchange in proteins analyzed by LC/MS. In this work, we explored the origin of carry-over in the online digestion of an IgG1 monoclonal antibody using an immobilized pepsin co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3feae29a25d4fc498a6027a0bcb6c8b0
https://pubmed.ncbi.nlm.nih.gov/22993047
https://pubmed.ncbi.nlm.nih.gov/22993047
Publikováno v:
Surgical infections. 7(3)
Background: Infection with Bacillus cereus is generally associated with gastrointestinal effects of food poisoning linked to infected rice. Isolates of B. cereus in hospital and clinical settings from any material other than vomitus or feces are comm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2809319bb8661aa8c44e41dca7a6f681
https://pubmed.ncbi.nlm.nih.gov/16875462
https://pubmed.ncbi.nlm.nih.gov/16875462
Autor:
Arora, Jayant, Hickey, John M, Majumdar, Ranajoy, Esfandiary, Reza, Bishop, Steven M, Samra, Hardeep S, Middaugh, C Russell, Weis, David D, Volkin, David B
Publikováno v:
mAbs; May/Jun2015, Vol. 7 Issue 3, p525-539, 15p