Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Jayamanna Wickramasinghe"'
Autor:
Abdurrahman Elbasir, Ying Ye, Daniel E. Schäffer, Xue Hao, Jayamanna Wickramasinghe, Konstantinos Tsingas, Paul M. Lieberman, Qi Long, Quaid Morris, Rugang Zhang, Alejandro A. Schäffer, Noam Auslander
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Here, Elbasir et al. develop viRNAtrap, a deep learning approach for detection of viruses from tumor RNA sequencing data, which they showcase on an RNA dataset of different cancer types, revealing tumor expression of divergent viruses that had not be
Externí odkaz:
https://doaj.org/article/421e42058eca41a19dcd684464f627fa
Autor:
Nitish Gulve, Chenhe Su, Zhong Deng, Samantha S. Soldan, Olga Vladimirova, Jayamanna Wickramasinghe, Hongwu Zheng, Andrew V. Kossenkov, Paul. M. Lieberman
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
The tumor suppressor proteins DAXX and ATRX are frequently mutated in cancers with alternative lengthening of telomeres (ALT). This study shows that DAXX-ATRX regulates p53 chromatin accessibility and DNA damage response and that disruption of this p
Externí odkaz:
https://doaj.org/article/d1a7392ad3ef4bfcb01ce66b8039e48c
Autor:
Rajasekharan Somasundaram, Thomas Connelly, Robin Choi, Hyeree Choi, Anastasia Samarkina, Ling Li, Elizabeth Gregorio, Yeqing Chen, Rohit Thakur, Mohamed Abdel-Mohsen, Marilda Beqiri, Meaghan Kiernan, Michela Perego, Fang Wang, Min Xiao, Patricia Brafford, Xue Yang, Xiaowei Xu, Anthony Secreto, Gwenn Danet-Desnoyers, Daniel Traum, Klaus H. Kaestner, Alexander C. Huang, Denitsa Hristova, Joshua Wang, Mizuho Fukunaga-Kalabis, Clemens Krepler, Fang Ping-Chen, Xiangyang Zhou, Alexis Gutierrez, Vito W. Rebecca, Prashanthi Vonteddu, Farokh Dotiwala, Shashi Bala, Sonali Majumdar, Harsh Dweep, Jayamanna Wickramasinghe, Andrew V. Kossenkov, Jorge Reyes-Arbujas, Kenisha Santiago, Tran Nguyen, Johannes Griss, Frederick Keeney, James Hayden, Brian J. Gavin, David Weiner, Luis J. Montaner, Qin Liu, Lukas Peiffer, Jürgen Becker, Elizabeth M. Burton, Michael A. Davies, Michael T. Tetzlaff, Kar Muthumani, Jennifer A. Wargo, Dmitry Gabrilovich, Meenhard Herlyn
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Immune checkpoint therapies (ICT) are promising for treating various cancers, but response rates vary. Here the authors show, in mouse models, that tumor-infiltrating mast cells colocalize with regulatory T cells, coincide with local reduction of MHC
Externí odkaz:
https://doaj.org/article/1dbc726f512b49e4900c71d53883f0cc
Autor:
R Jason Lamontagne, Samantha S Soldan, Chenhe Su, Andreas Wiedmer, Kyoung Jae Won, Fang Lu, Aaron R Goldman, Jayamanna Wickramasinghe, Hsin-Yao Tang, David W Speicher, Louise Showe, Andrew V Kossenkov, Paul M Lieberman
Publikováno v:
PLoS Pathogens, Vol 17, Iss 1, p e1009208 (2021)
Epstein-Barr virus (EBV) immortalizes resting B-lymphocytes through a highly orchestrated reprogramming of host chromatin structure, transcription and metabolism. Here, we use a multi-omics-based approach to investigate these underlying mechanisms. A
Externí odkaz:
https://doaj.org/article/48776a669bd044a5a1887f85a9a8d95d
Autor:
Salum J Lidenge, Andrew V Kossenkov, For Yue Tso, Jayamanna Wickramasinghe, Sara R Privatt, Owen Ngalamika, John R Ngowi, Julius Mwaiselage, Paul M Lieberman, John T West, Charles Wood
Publikováno v:
PLoS Pathogens, Vol 16, Iss 7, p e1008681 (2020)
In sub-Saharan Africa, endemic Kaposi's sarcoma (EnKS) is still prevalent despite high incidence of epidemic Kaposi's sarcoma (EpKS) resulting from the on-going HIV-1 epidemic. While KSHV is clearly the etiologic agent of KS, the mechanisms underlyin
Externí odkaz:
https://doaj.org/article/85190871773e4232b6735d2d920496ed
Autor:
For Yue Tso, Andrew V Kossenkov, Salum J Lidenge, Owen Ngalamika, John R Ngowi, Julius Mwaiselage, Jayamanna Wickramasinghe, Eun Hee Kwon, John T West, Paul M Lieberman, Charles Wood
Publikováno v:
PLoS Pathogens, Vol 14, Iss 1, p e1006844 (2018)
Kaposi's sarcoma-associated herpesvirus (KSHV) is the etiologic agent of Kaposi's sarcoma (KS). It is endemic in a number of sub-Saharan African countries with infection rate of >50%. The high prevalence of HIV-1 coupled with late presentation of adv
Externí odkaz:
https://doaj.org/article/1acd6058c27e4a469c29eb406424e40b
Autor:
Louise C. Showe, Michael K. Showe, William N. Rom, Brian Nam, Thomas Bauer, Anil Vachani, Sai Yendamuri, Harvey Pass, Jun-Chieh J. Tsay, Gerard Criner, Eric Konnisto, Wen-Hwai Horng, Trisha Kumar, Sandy Widura, Celia Chang, R. Sonali Majumdar, Qin Liu, Jayamanna Wickramasinghe, Noor B. Dawany, Rehman Qureshi, Andrew V. Kossenkov
Number of samples used on different platforms for training and validation sets
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ed581b92e9ff1a334657747171e4822
https://doi.org/10.1158/0008-5472.22420721.v1
https://doi.org/10.1158/0008-5472.22420721.v1
Autor:
Louise C. Showe, Michael K. Showe, William N. Rom, Brian Nam, Thomas Bauer, Anil Vachani, Sai Yendamuri, Harvey Pass, Jun-Chieh J. Tsay, Gerard Criner, Eric Konnisto, Wen-Hwai Horng, Trisha Kumar, Sandy Widura, Celia Chang, R. Sonali Majumdar, Qin Liu, Jayamanna Wickramasinghe, Noor B. Dawany, Rehman Qureshi, Andrew V. Kossenkov
Ranking of Nanostring Custom panel probes in nPNC classifier
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2582215c748c3d8255716f4e3f71eac0
https://doi.org/10.1158/0008-5472.22420727
https://doi.org/10.1158/0008-5472.22420727
Autor:
Louise C. Showe, Michael K. Showe, William N. Rom, Brian Nam, Thomas Bauer, Anil Vachani, Sai Yendamuri, Harvey Pass, Jun-Chieh J. Tsay, Gerard Criner, Eric Konnisto, Wen-Hwai Horng, Trisha Kumar, Sandy Widura, Celia Chang, R. Sonali Majumdar, Qin Liu, Jayamanna Wickramasinghe, Noor B. Dawany, Rehman Qureshi, Andrew V. Kossenkov
Performance of the Pulmonary Nodule Classifier
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b0ca7dea496561f808082b557b53d44
https://doi.org/10.1158/0008-5472.22420736
https://doi.org/10.1158/0008-5472.22420736
Autor:
Jose R. Conejo-Garcia, Tyler J. Curiel, Julia Tchou, Denise C. Connolly, Mark G. Cadungog, Qihong Huang, Kiranmai Gumireddy, Shane W. O'Brien, Jenny M. Nguyen, Jayamanna Wickramasinghe, Kyle K. Payne, Amelia J. Tesone, Michael J. Allegrezza, Melanie R. Rutkowski, Nikolaos Svoronos, Alfredo Perales-Puchalt
Supplemental Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48c0d085bfc91cfab795f294cedfcb6f
https://doi.org/10.1158/1078-0432.22467855
https://doi.org/10.1158/1078-0432.22467855