Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Jayakumar, Vadakekolathu"'
Promoter Methylation Leads to Hepatocyte Nuclear Factor 4A Loss and Pancreatic Cancer Aggressiveness
Autor:
Maria Hatziapostolou, Marina Koutsioumpa, Abed M. Zaitoun, Christos Polytarchou, Mouad Edderkaoui, Swapna Mahurkar-Joshi, Jayakumar Vadakekolathu, Daniel D'Andrea, Anna Rose Lay, Niki Christodoulou, Thuy Pham, Tung-On Yau, Christina Vorvis, Suchit Chatterji, Stephen J. Pandol, George A. Poultsides, David W. Dawson, Dileep N. Lobo, Dimitrios Iliopoulos
Publikováno v:
Gastro Hep Advances, Vol 3, Iss 5, Pp 687-702 (2024)
Background and Aims: Decoding pancreatic ductal adenocarcinoma heterogeneity and the consequent therapeutic selection remains a challenge. We aimed to characterize epigenetically regulated pathways involved in pancreatic ductal adenocarcinoma progres
Externí odkaz:
https://doaj.org/article/ed3b70b9de5c43699e1addca71804e12
Autor:
Adeola Grace Atobatele, Elisa Tonoli, Jayakumar Vadakekolathu, Maria Pia Savoca, Melissa Barr, Yukti Kataria, Marta Rossanese, Izhar Burhan, Stephanie McArdle, Daniela Caccamo, Elisabetta A. M. Verderio
Publikováno v:
Cell Death and Disease, Vol 14, Iss 5, Pp 1-13 (2023)
Abstract Androgen independency is associated with poor prostate cancer (PCa) survival. Here we report that silencing of transglutaminase-2 (TG2) expression by CRISPR-Cas9 is associated with upregulation of androgen receptor (AR) transcription in PCa
Externí odkaz:
https://doaj.org/article/13a9f2f11db04ec99babc1d5d0b686a3
Autor:
Sergio Rutella, Amanda Cashen, John Muth, Jayakumar Vadakekolathu, Laura Arthur, Nitin Mahajan, Melissa Berrien-Elliott, Jan Davidson-Moncada, Todd Fehniger
Publikováno v:
HemaSphere, Vol 7, p e4299744 (2023)
Externí odkaz:
https://doaj.org/article/fa6cbd1740c443c294aaafb9c1b05c16
Autor:
Carmela Ferri, Anna Di Biase, Marco Bocchetti, Silvia Zappavigna, Sarah Wagner, Pauline Le Vu, Amalia Luce, Alessia Maria Cossu, Jayakumar Vadakekolathu, Amanda Miles, David J. Boocock, Alex Robinson, Melanie Schwerdtfeger, Virginia Tirino, Federica Papaccio, Michele Caraglia, Tarik Regad, Vincenzo Desiderio
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 41, Iss 1, Pp 1-16 (2022)
Abstract Background The long non-coding RNA (lncRNA), MALAT1, plays a key role in the development of different cancers, and its expression is associated with worse prognosis in patients. However, its mechanism of action and its regulation are not wel
Externí odkaz:
https://doaj.org/article/6775aa52ba8e4162a369ebbfb370a0a7
Autor:
Sergio Rutella, Jayakumar Vadakekolathu, Francesco Mazziotta, Stephen Reeder, Tung-On Yau, Rupkatha Mukhopadhyay, Benjamin Dickins, Heidi Altmann, Michael Kramer, Hanna A. Knaus, Bruce R. Blazar, Vedran Radojcic, Joshua F. Zeidner, Andrea Arruda, Bofei Wang, Hussein A. Abbas, Mark D. Minden, Sarah K. Tasian, Martin Bornhäuser, Ivana Gojo, Leo Luznik
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 21 (2022)
Background Immune exhaustion and senescence are dominant dysfunctional states of effector T cells and major hurdles for the success of cancer immunotherapy. In the current study, we characterized how acute myeloid leukemia (AML) promotes the generati
Externí odkaz:
https://doaj.org/article/9b9ef0d762ff4c06a07a3be5dd99fa73
Autor:
Harshitha Shobha Manjunath MSc, Moza Al Khulaifi BSc, Heba Sidahmed MD, Adham Ammar MD, Jayakumar Vadakekolathu PhD, Sergio Rutella MD, Muneera Jassim Al-Mohannadi MD, Mamoun Elawad MD, William Mifsud MD, Adrian Charles MD, Cristina Maccalli PhD, Sara Tomei PhD
Publikováno v:
Technology in Cancer Research & Treatment, Vol 21 (2022)
The gene expression analysis of formalin-fixed paraffin-embedded (FFPE) tissues is often hampered by poor RNA quality, which results from the oxidation, cross-linking and other chemical modifications induced by the inclusion in paraffin. Yet, FFPE sa
Externí odkaz:
https://doaj.org/article/c2159ed4dd3044a4b8457e6205f6d71e
Autor:
Claudia Tulotta, Diane V. Lefley, Charlotte K. Moore, Ana E. Amariutei, Amy R. Spicer-Hadlington, Lewis A. Quayle, Russell O. Hughes, Khawla Ahmed, Victoria Cookson, Catherine A. Evans, Jayakumar Vadakekolathu, Paul Heath, Sheila Francis, Emmanuel Pinteaux, A. Graham Pockley, Penelope D. Ottewell
Publikováno v:
npj Breast Cancer, Vol 7, Iss 1, Pp 1-15 (2021)
Abstract Breast cancer bone metastasis is currently incurable, ~75% of patients with late-stage breast cancer develop disease recurrence in bone and available treatments are only palliative. We have previously shown that production of the pro-inflamm
Externí odkaz:
https://doaj.org/article/db7c85c82ea947e69d237a3402f52c96
Autor:
Raquel Alves, Stephanie E. B. McArdle, Jayakumar Vadakekolathu, Ana Cristina Gonçalves, Paulo Freitas-Tavares, Amélia Pereira, Antonio M. Almeida, Ana Bela Sarmento-Ribeiro, Sergio Rutella
Publikováno v:
Journal of Translational Medicine, Vol 18, Iss 1, Pp 1-15 (2020)
Abstract Background Tumor cells have evolved complex strategies to escape immune surveillance, a process which involves NK cells and T lymphocytes, and various immunological factors. Indeed, tumor cells recruit immunosuppressive cells [including regu
Externí odkaz:
https://doaj.org/article/e73c20ff4cc64a2a894e0706d59184ef
Autor:
Shaymaa IK. Al-Juboori, Jayakumar Vadakekolathu, Sarra Idri, Sarah Wagner, Dimitrios Zafeiris, Joshua RD. Pearson, Rukaia Almshayakhchi, Michele Caraglia, Vincenzo Desiderio, Amanda K. Miles, David J. Boocock, Graham R. Ball, Tarik Regad
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 38, Iss 1, Pp 1-14 (2019)
Abstract Background Metformin, a biguanide, is one of the most commonly prescribed treatments for type 2 diabetes and has recently been recommended as a potential drug candidate for advanced cancer therapy. Although Metformin has antiproliferative an
Externí odkaz:
https://doaj.org/article/1cd2486fd7f940c288cbd8bd63057da2
Autor:
Rukaia Almshayakhchi, Divya Nagarajan, Jayakumar Vadakekolathu, Barbara-Ann Guinn, Stephen Reeder, Victoria Brentville, Rachael Metheringham, A. Graham Pockley, Lindy Durrant, Stephanie McArdle
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Many cancers, including myeloid leukaemia express the cancer testis antigen (CTA) DDX43 (HAGE) and/or the oncogene Wilms’ tumour (WT1). Here we demonstrate that HAGE/WT1-ImmunoBody® vaccines derived T-cells can kill ex-vivo human CML cell lines ex
Externí odkaz:
https://doaj.org/article/f437f782c2b54899806b100305362a57