Hydrocarbon stapled B chain analogues of relaxin-3 retain biological activity

Autor: Jayakody, Tharindunee, Marwari, Subhi, Lakshminarayanan, Rajamani, Tan, Francis Chee Kuan, Johannes, Charles William, Dymock, Brian William, Poulsen, Anders, Herr, Deron Raymond, Dawe, Gavin Stewart

Publikováno v: In Peptides October 2016 84:44-57

Mechanisms of biased agonism by Gαi/o-biased stapled peptide agonists of the relaxin-3 receptor

Autor: Jayakody, Tharindunee, Inoue, Asuka, Kannan, Srinivasaraghavan, Nakamura, Gaku, Kawakami, Kouki, Mendis, Krishan, Nguyen, Thanh-Binh, Li, Jianguo, Herr, Deron R., Verma, Chandra S., Dawe, Gavin S.

Publikováno v: Science Signaling; February 2024, Vol. 17 Issue: 823

Mechanisms of biased agonism by Gα i/o -biased stapled peptide agonists of the relaxin-3 receptor.

Autor: Jayakody T; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Neurobiology Programme, Life Sciences Institute, National University of Singapore, Singapore.; Department of Chemistry, University of Colombo, P.O. Box 1490, Colombo 00300, Sri Lanka., Inoue A; Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan., Kannan S; Bioinformatics Institute, A*STAR, 30 Biopolis Street, #07-01 Matrix, Singapore 138671., Nakamura G; Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan., Kawakami K; Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan., Mendis K; Department of Chemistry, University of Colombo, P.O. Box 1490, Colombo 00300, Sri Lanka., Nguyen TB; Bioinformatics Institute, A*STAR, 30 Biopolis Street, #07-01 Matrix, Singapore 138671., Li J; Bioinformatics Institute, A*STAR, 30 Biopolis Street, #07-01 Matrix, Singapore 138671., Herr DR; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Verma CS; Bioinformatics Institute, A*STAR, 30 Biopolis Street, #07-01 Matrix, Singapore 138671.; Department of Biological Sciences, National University of Singapore, 6 Science Drive 4, Singapore 117558.; School of Biological Sciences, Nanyang Technological University, 60 Nanyang Dr., Singapore 637551., Dawe GS; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Neurobiology Programme, Life Sciences Institute, National University of Singapore, Singapore.; Healthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Precision Medicine Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

Publikováno v: Science signaling [Sci Signal] 2024 Feb 13; Vol. 17 (823), pp. eabl5880. Date of Electronic Publication: 2024 Feb 13.