Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Jayakanthan, Kumarasamy"'
Autor:
Prashant Monian, Chikdu Shivalila, Genliang Lu, Mamoru Shimizu, David Boulay, Karley Bussow, Michael Byrne, Adam Bezigian, Arindom Chatterjee, David Chew, Jigar Desai, Frank Favaloro, Jack Godfrey, Andrew Hoss, Naoki Iwamoto, Tomomi Kawamoto, Jayakanthan Kumarasamy, Anthony Lamattina, Amber Lindsey, Fangjun Liu, Richard Looby, Subramanian Marappan, Jake Metterville, Ronelle Murphy, Jeff Rossi, Tom Pu, Bijay Bhattarai, Stephany Standley, Snehlata Tripathi, Hailin Yang, Yuan Yin, Hui Yu, Cong Zhou, Luciano H. Apponi, Pachamuthu Kandasamy, Chandra Vargeese
Publikováno v:
Nature Biotechnology. 40:1093-1102
Technologies that recruit and direct the activity of endogenous RNA-editing enzymes to specific cellular RNAs have therapeutic potential, but translating them from cell culture into animal models has been challenging. Here we describe short, chemical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e36a5ee2c78d18679d808cc838638dd
https://doi.org/10.1038/s41587-022-01225-1
https://doi.org/10.1038/s41587-022-01225-1
Impact of guanidine-containing backbone linkages on stereopure antisense oligonucleotides in the CNS
Autor:
Pachamuthu Kandasamy, Yuanjing Liu, Vincent Aduda, Sandheep Akare, Rowshon Alam, Amy Andreucci, David Boulay, Keith Bowman, Michael Byrne, Megan Cannon, Onanong Chivatakarn, Juili Dilip Shelke, Naoki Iwamoto, Tomomi Kawamoto, Jayakanthan Kumarasamy, Sarah Lamore, Muriel Lemaitre, Xuena Lin, Kenneth Longo, Richard Looby, Subramanian Marappan, Jake Metterville, Susovan Mohapatra, Bridget Newman, Ik-Hyeon Paik, Saurabh Patil, Erin Purcell-Estabrook, Mamoru Shimizu, Pochi Shum, Stephany Standley, Kris Taborn, Snehlata Tripathi, Hailin Yang, Yuan Yin, Xiansi Zhao, Elena Dale, Chandra Vargeese
Publikováno v:
Nucleic Acids Research. 50:5401-5423
Attaining sufficient tissue exposure at the site of action to achieve the desired pharmacodynamic effect on a target is an important determinant for any drug discovery program, and this can be particularly challenging for oligonucleotides in deep tis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5bd2c8b0ca0bc373823740210c986ec
https://doi.org/10.1093/nar/gkac037
https://doi.org/10.1093/nar/gkac037
Autor:
Pachamuthu Kandasamy, Graham McClorey, Mamoru Shimizu, Nayantara Kothari, Rowshon Alam, Naoki Iwamoto, Jayakanthan Kumarasamy, Gopal R Bommineni, Adam Bezigian, Onanong Chivatakarn, David C D Butler, Michael Byrne, Katarzyna Chwalenia, Kay E Davies, Jigar Desai, Juili Dilip Shelke, Ann F Durbin, Ruth Ellerington, Ben Edwards, Jack Godfrey, Andrew Hoss, Fangjun Liu, Kenneth Longo, Genliang Lu, Subramanian Marappan, Jacopo Oieni, Ik-Hyeon Paik, Erin Purcell Estabrook, Chikdu Shivalila, Maeve Tischbein, Tomomi Kawamoto, Carlo Rinaldi, Joana Rajão-Saraiva, Snehlata Tripathi, Hailin Yang, Yuan Yin, Xiansi Zhao, Cong Zhou, Jason Zhang, Luciano Apponi, Matthew J A Wood, Chandra Vargeese
Publikováno v:
Nucleic acids research. 50(10)
Although recent regulatory approval of splice-switching oligonucleotides (SSOs) for the treatment of neuromuscular disease such as Duchenne muscular dystrophy has been an advance for the splice-switching field, current SSO chemistries have shown limi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4563bb9a20823ec7e04b7dd2e362f73
https://pubmed.ncbi.nlm.nih.gov/35061895
https://pubmed.ncbi.nlm.nih.gov/35061895
Autor:
Eskandari, Razieh, Jayakanthan, Kumarasamy, Kuntz, Douglas A., Rose, David R., Mario Pinto, B.
Publikováno v:
In Bioorganic & Medicinal Chemistry 2010 18(8):2829-2835
Publikováno v:
In Carbohydrate Research 2008 343(10):1790-1800
Autor:
Jayakanthan Kumarasamy, Mark A. Lehrman, B. Mario Pinto, Nabil G. Seidah, Ningguo Gao, Wesley F. Zandberg
Publikováno v:
ChemBioChem. 13:392-401
In a cell-based assay for novel inhibitors, we have discovered that two glycosides of 5-thiomannose, each containing an interglycosidic nitrogen atom, prevented the correct zymogen processing of the prohormone proopiomelanocortinin (POMC) and the tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70d1f46447a5be9931341c85fe294629
https://doi.org/10.1002/cbic.201100647
https://doi.org/10.1002/cbic.201100647
Autor:
Lyann Sim, Roberto Quezada-Calvillo, David R. Rose, Kyra Jones, B. Mario Pinto, Hassan Y. Naim, Jayakanthan Kumarasamy, Buford L. Nichols, Sankar Mohan, Hui Liu, Stephen E. Avery
Publikováno v:
Bioorganic & Medicinal Chemistry. 19:3929-3934
Inhibition of intestinal α-glucosidases and pancreatic α-amylases is an approach to controlling blood glucose and serum insulin levels in individuals with Type II diabetes. The two human intestinal glucosidases are maltase-glucoamylase and sucrase-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd16a44c3de31f911ef0e6c3da2ac0aa
https://doi.org/10.1016/j.bmc.2011.05.033
https://doi.org/10.1016/j.bmc.2011.05.033
Autor:
Mohan, Sankar, McAtamney, Sarah, Jayakanthan, Kumarasamy, Eskandari, Razieh, von Itzstein, Mark, Pinto, B. Mario
Publikováno v:
In International Journal of Antimicrobial Agents September 2012 40(3):273-276
Sialyl-Lewis X (sLe(X)) is a tetrasaccharide that serves as a ligand for the set of cell adhesion proteins known as selectins. This interaction enables adhesion of leukocytes and cancer cells to endothelial cells within capillaries, resulting in thei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b6be9d14ae0eda083b72e22e1619c56
https://europepmc.org/articles/PMC3501042/
https://europepmc.org/articles/PMC3501042/
Publikováno v:
Analytical chemistry. 82(12)
A simple and reproducible capillary-zone electrophoresis (CZE) method was developed for the separation and quantitation of sulfonium-ion-containing compounds isolated from plants of the Salacia genus which are traditionally used in Ayurvedic medicine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd23fc78cca231f859846193142909f7
https://pubmed.ncbi.nlm.nih.gov/20491445
https://pubmed.ncbi.nlm.nih.gov/20491445